ENGINEERING AZOHYDROMONAS LATA AND RALSTONIA EUTROPHA FOR THE PRODUCTION OF HYDROXY ACIDS.

Project Details

Description

The hydroxyacids 3-hydroxybutyrate and 2-hydroxyisobutyrate are chiral molecules that can be used as intermediates in the synthesis of high value products such as hormones, antibiotics and drugs. R. eutropha and A. lata were selected as the chassis for the production of these hydroxy acids because the accumulation of PHB in these organisms occurs at high rates as a non-growth and growth associated product, respectively, and PHB production as well as (R)-3-hydroxybutyryl-CoA and acetyl-CoA are regulated at the enzyme level by the availability of NAD(P)H
AcronymFONDECYT REGULAR - 1211434
StatusActive
Effective start/end date1/04/2131/03/25

Funding

  • Agencia Nacional de Investigación y Desarrollo (ANID), Chile: CLP197,816.00

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 9 - Industry, Innovation, and Infrastructure
  • SDG 13 - Climate Action

Disciplina principal ANID

  • BIOINGENIERÍA

Sector aplicación (ANID)

  • TÉCNICAS DE MANUFACTURAS Y DE PROCESOS. TÉCNICAS DE INGENIERÍA, INVESTIGACIÓN DE MATERIALES, PRODUCCIÓN DE LA INDUSTRIA QUÍMICA

Disciplina OCDE

  • BIOPRODUCTOS (PRODUCTOS QUE SE MANUFACTURAN USANDO BIOTECNOLOGIA COMO MATERIA PRIMA), BIOMATERIALES, BIOPLASTICOS, BIOCOMBUSTIBLES, QUIMICOS BRUTOS Y FINOS BIODERIVADOS, MATERIALES NUEVOS BIODERIVADOS