Projects per year
Personal profile
Research interests
My research interest has been focused on the study of the regenerative and immunosuppresive abilites of mesenchymal stem cells (MSC). Particularly in the last few years I have been studying the interaction of MSCs with cellls from the immune system particularly with pro-inflammatory Thelper 1 and Thelper17 lymphocytes.
Currently our research team is dedicated to evaluating the role of metabolism in the immunosuppressive and regenerative properties of MSCs and their extracellular derivatives including small microvesicles enriched in exosomes using murine models of diseases such as osteoarthritis, graft versus host disease, arthritis induced by collagen.
Education/Academic qualification
Biotecnología, Universidad de Santiago de Chile
… → 2012
University Degree, Ingeniero en Biotecnología, Universidad de Chile
University Degree, Médico Cirujano, Universidad de Chile
External positions
Investigador postdoctoral en la Unite Inserm 1183 en Montpellier, Francia., INSTITUT OF REGENERATIVE MEDICINE AND BIOTHERAPIES (IRMB), UNITE INSERM 1183, MONTPELLIER, FRANCE
16 Jan 2013 → 9 Jul 2016
Research Lines
- Research Lines
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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FONDECYT POSTDOCTORADO - 3250680: TRANSFERENCIA MITOCONDRIAL DERIVADA DE MSC COMO POTENCIAL HERRAMIENTA REGULATORIA DE LAS FUNCIONES INFLAMATORIAS DE DCS A TRAVÉS DE LA MODULACIÓN DE LA ACTIVIDAD UPR Y METABOLISMO ENERGÉTICO EN OBESIDAD
Luz Crawford, P. A. (Sponsoring Researcher) & Morales Reyes, J. A. (Principal Investigator)
Agencia Nacional de Investigación y Desarrollo
1/04/25 → 31/03/28
Project: RESEARCH
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FONDECYT REGULAR - 1250932: UNRAVELING THE ROLE OF MITOPHAGY TRIGGERED BY EXOGENOUS MSC-DERIVED MITOCHONDRIA ON MEMORY T-CD4 CELLS AS A NOVEL THERAPEUTIC MECHANISM FOR RHEUMATOID ARTHRITIS.
Luz Crawford, P. A. (Principal Investigator)
Agencia Nacional de Investigación y Desarrollo
1/04/25 → 31/03/29
Project: RESEARCH
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IDEA I+D TECNOLOGÍAS AVANZADAS - S/I: GLYCOSTEM-SEV, BIOFÁRMACO ACELULAR, PARA EL TRATAMIENTO DE OSTEOARTRITIS: DESARROLLO Y OPTIMIZACIÓN DE UN BIOPROCESO EFICIENTE A GRAN ESCALA Y VALIDACIÓN CLÍNICA
Luz Crawford, P. A. (Director), Toledo, J. (Alternate Director), Barahona, M. (Co-Investigator) & Ponce, D. (Co-Investigator)
1/01/24 → 1/01/27
Project: INNOVACIÓN Y DESARROLLO
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FONDECYT REGULAR - 1230932: THE POTENTIAL ROLE OF MENSTRUAL MESENCHYMAL STEM CELLS IN THE ETIOPATHOLOGY OF ENDOMETRIOSIS AND ITS ASSOCIATION WITH IMPAIRED ENDOMETRIUM RECEPTIVITY
J. Monteiro, L. (Principal Investigator), Donoso, M. B. (Co-Investigator), Vega-Letter, A. M. (Co-Investigator), Illanes, S. (Co-Investigator) & Luz Crawford, P. A. (Co-Investigator)
Agencia Nacional de Investigación y Desarrollo
1/04/23 → 31/03/27
Project: RESEARCH
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IMPACT: CENTER OF INTERVENTIONAL MEDICINE FOR PRECISION AND ADVANCED CELLULAR THERAPY
Khoury, M. (Director), Alcayaga-Miranda, F. (Principal Investigator), Cuenca, J. (Principal Investigator), Acevedo, J. P. (Principal Investigator), Figueroa, F. (Principal Investigator), Luz Crawford, P. A. (Principal Investigator), Wyneken, Ú. (Principal Investigator), Illanes, S. (Principal Investigator), Batiz, L. F. (Associate Investigator), Busso, D. (Associate Investigator), J. Monteiro, L. (Associate Investigator), Nardocci, G. (Associate Investigator), Enrione, J. I. (Associate Investigator), Espinoza, F. (Associate Investigator), Valenzuela Bravo, M. T. (Associate Investigator) & Prieto, M. (Associate Investigator)
Agencia Nacional de Investigación y Desarrollo
1/11/21 → 31/10/26
Project: RESEARCH
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A novel brain-to-gut communication pathway mediated by astrocyte-derived small extracellular vesicles modulates stress-induced intestinal inflammation
Yantén-Fuentes, L., Pizarro, M., Rojas, C., Pradenas, C., Méndez-Ruette, M., Corvalán, K., Bustos, G., Luarte, A., Batiz, L. F., Luz-Crawford, P., Pino-Lagos, K. & Wyneken, U., 2025, (Accepted/In press) In: Molecular Psychiatry.Research output: Contribution to journal › Article › peer-review
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Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis
Figueroa-Valdés, A. I., Luz-Crawford, P., Herrera-Luna, Y., Georges-Calderón, N., García, C., Tobar, H. E., Araya, M. J., Matas, J., Donoso-Meneses, D., de la Fuente, C., Cuenca, J., Parra, E., Lillo, F., Varela, C., Cádiz, M. I., Vernal, R., Ortloff, A., Nardocci, G., Castañeda, V. & Adasme-Vidal, C. & 5 others, , Dec 2025, In: Journal of Nanobiotechnology. 23, 1, 13.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Galectin-9 and Tim-3 in gastric cancer: a checkpoint axis driving T cell exhaustion and Treg-mediated immunosuppression independently of anti-PD-1 blockade
Hill, C. N., Maita, G., Cabrolier, C., Aros, C., Vega-Letter, A. M., Gonzalez, P., Kalergis, A. M., Luz-Crawford, P. & Owen, G. I., 2025, In: Frontiers in Immunology. 16, 1600792.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Mitochondria-derived reactive oxygen species induce over-differentiation of neural stem/progenitor cells after non-cytotoxic cisplatin exposure
Bustamante-Barrientos, F. A., Lara-Barba, E., Herrera-Luna, Y., García-Guerrero, C., Silva-Pavez, E., Morales-Reyes, J., Araya, M. J., Yanten-Fuentes, L., Luque-Campos, N., Altamirano, C., Vega-Letter, A. M. & Luz-Crawford, P., 2025, In: Frontiers in Cell and Developmental Biology. 13, 1555153.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
New mesenchymal stem/stromal cell-based strategies for osteoarthritis treatment: targeting macrophage-mediated inflammation to restore joint homeostasis
Araya-Sapag, M. J., Lara-Barba, E., García-Guerrero, C., Herrera-Luna, Y., Flores-Elías, Y., Bustamante-Barrientos, F. A., Albornoz, G. G., Contreras-Fuentes, C., Yantén-Fuentes, L., Luque-Campos, N., Vega-Letter, A. M., Toledo, J. & Luz-Crawford, P., Jun 2025, In: Journal of Molecular Medicine. 103, 6, p. 651-669 19 p.Research output: Contribution to journal › Review article › peer-review
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PAR EVALUADOR DOCTORADO EN BIOMEDICINA UNAB
Luz Crawford, P. A. (Consultant)
2020Activity: Consultancy
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PAR EVALUADOR DOCTORADO CIENCIAS MEDICAS UDD
Luz Crawford, P. A. (Consultant)
2019Activity: Consultancy
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Mesenchymal stem cell-transferred mitochondria elicit an immune function reprogramming that entails T regulatory cell commitment and clinical improvement of graft vs host disease
Court, A. C. (Speaker), Le-Gatt, A. (Keynote speaker), Luz Crawford, P. A. (Speaker), Aliaga-Tobar, V. (Speaker), Batiz, L. F. (Speaker), Parra, E. (Speaker), Contreras, R. (Speaker), Ortúzar, M. I. (Speaker), Kurte, M. (Speaker), Elizondo-Vega, R. (Speaker), Maracaja-Coutinho, V. (Speaker), Pino-Lagos, K. (Speaker), Velarde, R. (Speaker), Khoury, M. (Speaker) & Figueroa, F. (Speaker)
2019Activity: Talk or presentation › Oral presentation
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Metabolism regulates the immunosuppresive activity of mesenchymal stem/stromal cells
Luz Crawford, P. A. (Speaker)
2019Activity: Talk or presentation › Oral presentation
Courses
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Avances en terapia celular
Luz Crawford, P. A., Cuenca, J., Alcayaga-Miranda, F., Khoury, M. & Acevedo, J. P. 13/08/21 → 17/12/21
Course
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DOCB1110 Biología Celular y Molecular en Biomedicina
J. Monteiro, L., Nardocci, G., Batiz, L. F., Busso, D., Acevedo, J. P., Luz Crawford, P. A. & Wyneken, Ú. 22/03/21 → 30/06/21
Course
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DOCB1210 Avances Biotecnológicos en Medicina
Course
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Introduccion a la Medicina Regenerativa
Luz Crawford, P. A., Khoury, M. & Alcayaga-Miranda, F. 11/03/21 → 16/07/21
Course
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INTRODUCCION A LA MEDICINA REGENERATIVA
Luz Crawford, P. A., Alcayaga-Miranda, F. & Khoury, M. 14/08/20 → 18/12/20
Course