Projects per year
Personal profile
Additional Research Interests
My research interest has been focused on the study of the regenerative and immunosuppresive abilites of mesenchymal stem cells (MSC). Particularly in the last few years I have been studying the interaction of MSCs with cellls from the immune system particularly with pro-inflammatory Thelper 1 and Thelper17 lymphocytes.
Currently our research team is dedicated to evaluating the role of metabolism in the immunosuppressive and regenerative properties of MSCs and their extracellular derivatives including small microvesicles enriched in exosomes using murine models of diseases such as osteoarthritis, graft versus host disease, arthritis induced by collagen.
Education/Academic qualification
Biotecnología, Universidad de Santiago de Chile
… → 2012
University Degree, Ingeniero en Biotecnología, Universidad de Chile
University Degree, Médico Cirujano, Universidad de Chile
External positions
Investigador postdoctoral en la Unite Inserm 1183 en Montpellier, Francia., INSTITUT OF REGENERATIVE MEDICINE AND BIOTHERAPIES (IRMB), UNITE INSERM 1183, MONTPELLIER, FRANCE
16 Jan 2013 → 9 Jul 2016
Research Lines
- Research Lines
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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FONDECYT REGULAR - 1230932: THE POTENTIAL ROLE OF MENSTRUAL MESENCHYMAL STEM CELLS IN THE ETIOPATHOLOGY OF ENDOMETRIOSIS AND ITS ASSOCIATION WITH IMPAIRED ENDOMETRIUM RECEPTIVITY
J. Monteiro, L. (Principal Investigator), Donoso, M. B. (Co-Investigator), Vega-Letter, A. M. (Co-Investigator), Illanes, S. (Co-Investigator) & Luz Crawford, P. A. (Co-Investigator)
Agencia Nacional de Investigación y Desarrollo (ANID)
1/04/23 → 31/03/27
Project: Research
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FONDECYT POSTDOCTORADO - 3220204: TRANSFERENCIA MITOCONDRIAL DESDE CÉLULAS MADRE MESENQUIMALES COMO UNA NUEVA ALTERNATIVA TERAPÉUTICA PARA DESÓRDENES DEL NEURODESARROLLO: RELEVANCIA EN EL RESCATE METABÓLICO Y FUNCIONAL DE CÉLULAS MADRE NEURALES
Luz Crawford, P. A. (Sponsoring Researcher) & Bustamante, F. A. (Postdoctoral Researcher)
Agencia Nacional de Investigación y Desarrollo (ANID)
15/04/22 → 14/04/25
Project: Research
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IMPACT: CENTER OF INTERVENTIONAL MEDICINE FOR PRECISION AND ADVANCED CELLULAR THERAPY
Khoury, M. (Director), Alcayaga-Miranda, F. (Principal Investigator), Cuenca, J. (Principal Investigator), Acevedo, J. P. (Principal Investigator), Figueroa, F. (Principal Investigator), Luz Crawford, P. A. (Principal Investigator), Wyneken, Ú. (Principal Investigator), Illanes, S. (Principal Investigator), Batiz, L. F. (Associate Investigator), Busso, D. (Associate Investigator), J. Monteiro, L. (Associate Investigator), Nardocci, G. (Associate Investigator), Enrione, J. I. (Associate Investigator), Espinoza, F. (Associate Investigator), Valenzuela Bravo, M. T. (Associate Investigator) & Prieto, M. (Associate Investigator)
Agencia Nacional de Investigación y Desarrollo (ANID)
1/11/21 → 31/10/26
Project: Research
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FONDECYT REGULAR - 1211749: IMPACT OF HORIZONTAL ARTIFICIAL TRANSFER OF MITOCHONDRIA ON UMBILICAL CORD BLOOD TRANSPLANTATION AND ITS CLINICAL RELEVANCE IN GRAFT VERSUS HOST DISEASE.
Khoury, M. (Principal Investigator), Luz Crawford, P. A. (Co-Investigator), Court, A. C. (Co-Investigator) & Figueroa, F. (Co-Investigator)
Agencia Nacional de Investigación y Desarrollo (ANID)
1/04/21 → 31/03/25
Project: Research
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FONDECYT REGULAR - 1211353: INVESTIGATING THE IMMUNOREGULATORY AND ANTI-RHEUMATOID ARTHRITIS ACTIVITIES OF SMALL EXTRACELLULAR VESICLES-SHUTTLED BIOACTIVE MICRORNA DERIVED FROM GLYCOLYTIC MESENCHYMAL STEM CELL
Luz Crawford, P. A. (Principal Investigator), Khoury, M. (Co-Investigator), Alcayaga-Miranda, F. (Co-Investigator), Elizondo-Vega, R. (Co-Investigator), Altamirano, C. (Co-Investigator) & Nova-Lamperti, E. (Co-Investigator)
Agencia Nacional de Investigación y Desarrollo (ANID)
1/04/21 → 31/03/25
Project: Research
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A Phase I Dose-Escalation Clinical Trial to Assess the Safety and Efficacy of Umbilical Cord-Derived Mesenchymal Stromal Cells in Knee Osteoarthritis
Matas, J., García, C., Poblete, D., Vernal, R., Ortloff, A., Luque-Campos, N., Hidalgo, Y., Cuenca, J., Infante, C., Cadiz, M. I., Khoury, M., Luz-Crawford, P. & Espinoza, F., Mar 2024, In: Stem cells translational medicine. 13, 3, p. 193-203 11 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
How to enhance MSCs therapeutic properties? An insight on potentiation methods
Guerrero, C. A. G., Fuentes, P., Araya, M. J., Djouad, F., Luz-Crawford, P., Vega-Letter, A. M. & Altamirano, C., 27 Sep 2024, In: Stem Cell Research and Therapy. 15, 1, p. 331 1 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Isolation of Intestinal Macrophage Subpopulations for High-Quality Total RNA Purification in Zebrafish
Del Río-Jay, Y., Barthelaix, A., Reyes-Martínez, C., Duperray, C., Solis-Cascante, C. J., Hidalgo, Y., Luz-Crawford, P., Djouad, F. & Feijoo, C. G., Jun 2024, In: Methods and Protocols. 7, 3, 43.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitochondrial transfer balances cell redox, energy and metabolic homeostasis in the osteoarthritic chondrocyte preserving cartilage integrity
Court, A. C., Vega-Letter, A. M., Parra-Crisóstomo, E., Velarde, F., García, C., Ortloff, A., Vernal, R., Pradenas, C., Luz-Crawford, P., Khoury, M. & Figueroa, F. E., 2024, In: Theranostics. 14, 17, p. 6471-6486 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Regulatory T cells administration reduces anxiety-like behavior in mice submitted to chronic restraint stress
Cepeda, Y., Elizondo-Vega, R., Garrido, C., Tobar, C., Araneda, M., Oliveros, P., Ordenes, P., Carril, C., Vidal, P. M., Luz-Crawford, P., García-Robles, M. A. & Oyarce, K., 2024, In: Frontiers in Cellular Neuroscience. 18, 1406832.Research output: Contribution to journal › Article › peer-review
Open Access
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PAR EVALUADOR DOCTORADO EN BIOMEDICINA UNAB
Luz Crawford, P. A. (Consultant)
2020Activity: Consultancy
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Metabolism regulates the immunosuppresive activity of mesenchymal stem/stromal cells
Luz Crawford, P. A. (Speaker)
2019Activity: Talk or presentation › Oral presentation
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PAR EVALUADOR DOCTORADO CIENCIAS MEDICAS UDD
Luz Crawford, P. A. (Consultant)
2019Activity: Consultancy
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Mesenchymal stem cell-transferred mitochondria elicit an immune function reprogramming that entails T regulatory cell commitment and clinical improvement of graft vs host disease
Court, A. C. (Speaker), Le-Gatt, A. (Keynote speaker), Luz Crawford, P. A. (Speaker), Aliaga-Tobar, V. (Speaker), Batiz, L. F. (Speaker), Parra, E. (Speaker), Contreras, R. (Speaker), Ortúzar, M. I. (Speaker), Kurte, M. (Speaker), Elizondo-Vega, R. (Speaker), Maracaja-Coutinho, V. (Speaker), Pino-Lagos, K. (Speaker), Velarde, R. (Speaker), Khoury, M. (Speaker) & Figueroa, F. (Speaker)
2019Activity: Talk or presentation › Oral presentation