Projects per year
Personal profile
Research Interests
My research interest has been focused on the study of the regenerative and immunosuppresive abilites of mesenchymal stem cells (MSC). Particularly in the last few years I have been studying the interaction of MSCs with cellls from the immune system particularly with pro-inflammatory Thelper 1 and Thelper17 lymphocytes. Currently our research team is dedicated to evaluating the role of metabolism in the immunosuppressive and regenerative properties of MSCs and their extracellular derivatives including small microvesicles enriched in exosomes using murine models of diseases such as osteoarthritis, graft versus host disease, arthritis induced by collagen.
External positions
Investigador postdoctoral en la Unite Inserm 1183 en Montpellier, Francia., INSTITUT OF REGENERATIVE MEDICINE AND BIOTHERAPIES (IRMB), UNITE INSERM 1183, MONTPELLIER, FRANCE
16 Jan 2013 → 9 Jul 2016
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Glycostem-sev: generación de un producto acelular basado en nanovesículas extracelulares derivadas de células madre mesenquimales inducidas hacia un metabolismo glicolítico para el tratamiento de la osteoartritis
Luz Crawford, P. A., Alcayaga-Miranda, F., Elizondo-Vega, R. J., Espinoza, F. & Matas, J.
Agencia Nacional de Investigación y Desarrollo (ANID), Chile
1/11/21 → 30/11/23
Project: Research
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Center of Interventional Medicine for Precision and Advanced Cellular Therapy (IMPACT)
Khoury, M., Alcayaga-Miranda, F., Cuenca, J., Acevedo, J. P., Figueroa, F., Luz Crawford, P. A., Wyneken, Ú., Illanes, S., Batiz, L. F., Busso, D., J. Monteiro, L., Nardocci, G., Enrione, J., Espinoza, F., Valenzuela Bravo, M. T. & Prieto, M.
Agencia Nacional de Investigación y Desarrollo (ANID), Chile
1/11/21 → 31/10/26
Project: Research
Research output
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GKRP-dependent modulation of feeding behavior by tanycyte-released monocarboxylates
Salgado, M., Elizondo-Vega, R., Villar, P. S., Konar, M., Gallegos, S., Tarifeño-Saldivia, E., Luz-Crawford, P., Aguayo, L. G., Araneda, R. C., Uribe, E. & García-Robles, M. Á., 2022, In: Theranostics. 12, 4, p. 1518-1536 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Human MuStem cells repress T-cell proliferation and cytotoxicity through both paracrine and contact-dependent pathways
Charrier, M., Lorant, J., Contreras-Lopez, R., Téjédor, G., Blanquart, C., Lieubeau, B., Schleder, C., Leroux, I., Deshayes, S., Fonteneau, J. F., Babarit, C., Hamel, A., Magot, A., Péréon, Y., Viau, S., Delorme, B., Luz-Crawford, P., Lamirault, G., Djouad, F. & Rouger, K., 10 Jan 2022, In: Stem Cell Research and Therapy. 13, 1, p. 7 7.Research output: Contribution to journal › Article › peer-review
Open Access -
PPARβ/δ priming enhances the anti-apoptotic and therapeutic properties of mesenchymal stromal cells in myocardial ischemia–reperfusion injury
Sarre, C., Contreras-Lopez, R., Nernpermpisooth, N., Barrere, C., Bahraoui, S., Terraza, C., Tejedor, G., Vincent, A., Luz-Crawford, P., Kongpol, K., Kumphune, S., Piot, C., Nargeot, J., Jorgensen, C., Djouad, F. & Barrere-Lemaire, S., Dec 2022, In: Stem Cell Research and Therapy. 13, 1, p. 167 167.Research output: Contribution to journal › Article › peer-review
Open Access -
MANF Produced by MRL Mouse-Derived Mesenchymal Stem Cells Is Pro-regenerative and Protects From Osteoarthritis
Tejedor, G., Luz Crawford, P. A., Barthelaix, A., Toupet, K., Roudières, S., Autelitano, F., Jorgensen, C. & Djouad, F., 2 Mar 2021, In: Frontiers in Cell and Developmental Biology. 9, p. 579951 579951.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
NRG1/ErbB signalling controls the dialogue between macrophages and neural crest-derived cells during zebrafish fin regeneration
Laplace-Builhé, B., Barthelaix, A., Assou, S., Bohaud, C., Pratlong, M., Severac, D., Tejedor, G., Luz-Crawford, P., Nguyen-Chi, M., Mathieu, M., Jorgensen, C. & Djouad, F., 3 Nov 2021, In: Nature Communications. 12, 1, p. 6336 6336.Research output: Contribution to journal › Article › peer-review
Open Access
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PAR EVALUADOR DOCTORADO EN BIOMEDICINA UNAB
Patricia Alejandra Luz Crawford (Consultant)
2020Activity: Consultancy
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Metabolism regulates the immunosuppresive activity of mesenchymal stem/stromal cells
Patricia Alejandra Luz Crawford (Speaker)
2019Activity: Talk or presentation › Oral presentation
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Mesenchymal stem cell-transferred mitochondria elicit an immune function reprogramming that entails T regulatory cell commitment and clinical improvement of graft vs host disease
Angela C. Court (Speaker), Alice Le-Gatt (Keynote speaker), Patricia Alejandra Luz Crawford (Speaker), Victor Aliaga-Tobar (Speaker), Luis Federico Batiz (Speaker), Eliseo Parra (Speaker), Rafael Contreras (Speaker), María Ignacia Ortúzar (Speaker), Mónica Kurte (Speaker), Roberto Elizondo-Vega (Speaker), Vinicius Maracaja-Coutinho (Speaker), Karina Pino-Lagos (Speaker), Radmila Velarde (Speaker), Maroun Khoury (Speaker) & Fernando Figueroa (Speaker)
2019Activity: Talk or presentation › Oral presentation
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PAR EVALUADOR DOCTORADO CIENCIAS MEDICAS UDD
Patricia Alejandra Luz Crawford (Consultant)
2019Activity: Consultancy
Courses
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Avances en terapia celular
Patricia Alejandra Luz Crawford, Jimena Cuenca, Francisca Alcayaga-Miranda, Maroun Khoury & Juan Pablo Acevedo 13/08/21 → 17/12/21
Course
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DOCB1210 Avances Biotecnológicos en Medicina
Course
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Introduccion a la Medicina Regenerativa
Patricia Alejandra Luz Crawford, Maroun Khoury & Francisca Alcayaga-Miranda 11/03/21 → 16/07/21
Course
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INTRODUCCION A LA MEDICINA REGENERATIVA
Patricia Alejandra Luz Crawford, Francisca Alcayaga-Miranda & Maroun Khoury 14/08/20 → 18/12/20
Course