Projects per year
Personal profile
Professional Information
He obtained a Ph.D. in health and biology from the University of Montpellier, France, focusing on gene therapy in joint diseases, where a constellation of gene therapy strategies were used included RNA interference, viral- and liposome-based vectors. The successful outcome of these approaches resulted in multiple high impact publications, conveying the opportunity for a postdoctoral position at the MIT, Koch Institute, Cambridge, Massachusetts. At MIT, he focused his effort on establishing a humanized mouse model; a mouse with a human blood system. This was followed by a position at the MIT-Singapore alliance for research and technology (SMART), in Singapore, where he worked on hematopoietic and fetal stem cells. Following this enriching experience, he established his own research laboratory of nanoRegenerative medicine, in Santiago de Chile, where he currently directs a young team of highly motivated researchers. The laboratory is located at the Universidad de Los Andes and affiliated to a biotechnology venture, Cells for Cells, where he currently hold a dual position as an A/Professor and Chief Scientific Officer (CSO) at Cells for Cells and Regenero (co-founder), the Chilean consortium for Regenerative medicine.
Additional Research Interests
With a keen interest in bridging the bench work to the bedside, his team is carrying out research with the objective of developing treatments and therapeutics against diseases of public health and economic importance that are impacting the daily life of people living in Chile. This vanguard expertise was capitalized in several clinical application in diseases with unmet medical needs such as heart failure, Osteoarthritis, lupus and pulpitis.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Ciencias Biológicas, Université de Montpellier
… → 2007
University Degree, Biólogo, Université Paul-Valéry Montpellier III
External positions
Chief Scientific Officer, Cells for Cells
9 Jun 2011 → …
Open Keywords
- cell therapy
Research Lines
- Research Lines
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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FONDEF IDEA I+D 2023 - 23I10325: Desarrollo de un producto alogénico basado en un hidrogel bioactivo con nanovesículas extracelulares y su validación como tratamiento endodóntico regenerativo
Cuenca, J. (Principal Investigator), Brizuela Cordero, C. I. (Alternate Director), Khoury, M. (Co-Investigator), Alcayaga-Miranda, F. (Co-Investigator), Canedo Marroquin, G. (Co-Investigator) & González-Arriagada, W. A. (Co-Investigator)
National Agency for Research and Development (ANID)
15/06/23 → 15/06/25
Project: Research
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FONDECYT REGULAR - 1230875: REVEALING THE CONTRIBUTION OF MELANOMA-DERIVED CIRCULATING CELL-FREE MITOCHONDRIA IN THE FORMATION OF PREMETASTATIC NICHE IN LYMPH NODES AND THEIR IMPACT IN THE EARLY DEVELOPMENT OF METASTASIS
Alcayaga-Miranda, F. (Principal Investigator), Khoury, M. (Co-Investigator), Pino-Lagos, K. (Co-Investigator), Hidalgo, Y. (Co-Investigator) & González-Arriagada, W. A. (Co-Investigator)
Agencia Nacional de Investigación y Desarrollo (ANID)
1/04/23 → 31/03/27
Project: Research
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IMPACT: CENTER OF INTERVENTIONAL MEDICINE FOR PRECISION AND ADVANCED CELLULAR THERAPY
Khoury, M. (Director), Alcayaga-Miranda, F. (Principal Investigator), Cuenca, J. (Principal Investigator), Acevedo, J. P. (Principal Investigator), Figueroa, F. (Principal Investigator), Luz Crawford, P. A. (Principal Investigator), Wyneken, Ú. (Principal Investigator), Illanes, S. (Principal Investigator), Batiz, L. F. (Associate Investigator), Busso, D. (Associate Investigator), J. Monteiro, L. (Associate Investigator), Nardocci, G. (Associate Investigator), Enrione, J. I. (Associate Investigator), Espinoza, F. (Associate Investigator), Valenzuela Bravo, M. T. (Associate Investigator) & Prieto, M. (Associate Investigator)
Agencia Nacional de Investigación y Desarrollo (ANID)
1/11/21 → 31/10/26
Project: Research
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FONDECYT REGULAR - 1211376: INVESTIGATING THE EFFECT OF MAVS-ENRICHED MITOCHONDRIAL TRANSPLANTATION ON INTRACELLULAR ANTIVIRAL IMMUNITY AND THEIR RESTORATIVE AND IMMUNOMODULATORY EFFECTS IN A VIRAL-INDUCED ACUTE LUNG INJURY MODEL.
Cuenca, J. (Principal Investigator), Alcayaga-Miranda, F. (Co-Investigator), Khoury, M. (Co-Investigator), Hidalgo, Y. (Co-Investigator) & Kurte, M. (Principal Investigator)
Agencia Nacional de Investigación y Desarrollo (ANID)
1/04/21 → 31/03/25
Project: Research
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INVESTIGATING THE EFFECT OF MAVS ENRICHED MITOCHONDRIAL TRANSPLANTATION ON INTRACELLULAR ANTIVIRAL IMMUNITY AND THEIR RESTORATIVE AND IMMUNOMODULATORY EFFECTS IN A VIRALINDUCED ACUTE LUNG INJURY MODEL
Cuenca, J. (Principal Investigator), Alcayaga-Miranda, F. (Co-Investigator), Khoury, M. (Co-Investigator), Hidalgo, Y. (Co-Investigator) & Kurte, M. (Co-Investigator)
Agencia Nacional de Investigación y Desarrollo (ANID)
1/04/21 → 31/03/25
Project: Research
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Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis
Figueroa-Valdés, A. I., Luz-Crawford, P., Herrera-Luna, Y., Georges-Calderón, N., García, C., Tobar, H. E., Araya, M. J., Matas, J., Donoso-Meneses, D., de la Fuente, C., Cuenca, J., Parra, E., Lillo, F., Varela, C., Cádiz, M. I., Vernal, R., Ortloff, A., Nardocci, G., Castañeda, V. & Adasme-Vidal, C. & 5 others, , Dec 2025, In: Journal of Nanobiotechnology. 23, 1, 13.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Recommendations for mitochondria transfer and transplantation nomenclature and characterization
Brestoff, J. R., Singh, K. K., Aquilano, K., Becker, L. B., Berridge, M. V., Boilard, E., Caicedo, A., Crewe, C., Enríquez, J. A., Gao, J., Gustafsson, Å. B., Hayakawa, K., Khoury, M., Lee, Y. S., Lettieri-Barbato, D., Luz-Crawford, P., McBride, H. M., McCully, J. D., Nakai, R. & Neuzil, J. & 11 others, , Jan 2025, In: Nature Metabolism. 7, 1, p. 53-67 15 p., 31.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Safety and efficacy of mesenchymal stromal cells mitochondria transplantation as a cell-free therapy for osteoarthritis
Vega-Letter, A. M., García-Guerrero, C., Yantén-Fuentes, L., Pradenas, C., Herrera-Luna, Y., Lara-Barba, E., Bustamante-Barrientos, F. A., Rojas, M., Araya, M. J., Jeraldo, N., Aros, C., Troncoso, F., Poblete, D., Court, A., Ortloff, A., Barraza, J., Velarde, F., Farkas, C., Carril, C. & Luque-Campos, N. & 16 others, , Dec 2025, In: Journal of Translational Medicine. 23, 1, 26.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
A Phase I Dose-Escalation Clinical Trial to Assess the Safety and Efficacy of Umbilical Cord-Derived Mesenchymal Stromal Cells in Knee Osteoarthritis
Matas, J., García, C., Poblete, D., Vernal, R., Ortloff, A., Luque-Campos, N., Hidalgo, Y., Cuenca, J., Infante, C., Cadiz, M. I., Khoury, M., Luz-Crawford, P. & Espinoza, F., Mar 2024, In: Stem cells translational medicine. 13, 3, p. 193-203 11 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development
Vacarezza, C., Araneda, J., Gonzalez, P., Arteaga, O., Marcelain, K., Castellon, E. A., Periera, A., Khoury, M., Müller, B., Lecaros, J. A., Salas, S. P., Riquelme, A., Corvalan, A. H., de la Jara, J. J., Ferreccio, C., Goic, C., Nervi, B., Roa, J. C. & Owen, G. I., Dec 2024, In: Biological Research. 57, 1, 95.Research output: Contribution to journal › Article › peer-review
Open Access
Activities
- 2 Oral presentation
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Mesenchymal stem cell-transferred mitochondria elicit an immune function reprogramming that entails T regulatory cell commitment and clinical improvement of graft vs host disease
Court, A. C. (Speaker), Le-Gatt, A. (Keynote speaker), Luz Crawford, P. A. (Speaker), Aliaga-Tobar, V. (Speaker), Batiz, L. F. (Speaker), Parra, E. (Speaker), Contreras, R. (Speaker), Ortúzar, M. I. (Speaker), Kurte, M. (Speaker), Elizondo-Vega, R. (Speaker), Maracaja-Coutinho, V. (Speaker), Pino-Lagos, K. (Speaker), Velarde, R. (Speaker), Khoury, M. (Speaker) & Figueroa, F. (Speaker)
2019Activity: Talk or presentation › Oral presentation
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workshop de procedimientos de endodoncia regenerativa
Brizuela Cordero, C. (Speaker) & Khoury, M. (Speaker)
31 May 2018Activity: Talk or presentation › Oral presentation
Courses
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Avances en terapia celular
Luz Crawford, P. A., Cuenca, J., Alcayaga-Miranda, F., Khoury, M. & Acevedo, J. P. 13/08/21 → 17/12/21
Course
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DOCB1210 Avances Biotecnológicos en Medicina
Course
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Introduccion a la Medicina Regenerativa
Luz Crawford, P. A., Khoury, M. & Alcayaga-Miranda, F. 11/03/21 → 16/07/21
Course
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INTRODUCCION A LA MEDICINA REGENERATIVA
Luz Crawford, P. A., Alcayaga-Miranda, F. & Khoury, M. 14/08/20 → 18/12/20
Course
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TERAPIA CELULAR Y MEDICINA REGENERATIVA
Luz Crawford, P. A., Alcayaga-Miranda, F., Khoury, M. & Cuenca, J. 14/08/18 → 21/12/18
Course
Press/Media
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VEINTIS™ the tissue-engineered vascular graft developed by Cells for Cells, wins the 2020 National Innovation Prize
13/11/20
1 item of Media coverage
Press/Media