Projects per year
Personal profile
Professional Information
I am a biologist and hold a Master's degree in Cellular Biology and Physiology from the University of Paris Cité, and a PhD in Medical Sciences from the Catholic University of Chile.
I completed postdoctoral studies at the European Center for the Study of Diabetes in Strasbourg, France, thanks to a prestigious Marie Skłodowska-Curie scholarship.
Upon my return to Chile, I joined the Universidad de los Andes, where I work as a research professor.
In 2023, I was awarded a Fondecyt Initiation project, which is carried out in the Periodontal Research Laboratory at the Center for Biomedical Research and Innovation.
Teaching
The teaching areas where I have worked have mainly been training students during their undergraduate and Master's theses, both in France (University of Strasbourg) and in Chile at the University of the Andes.
Research interests
My line of research is framed in inter-organ communication and the regulation of insulin secretion (integrative physiology).
As has been described in recent years, there is a complex coordination between different organs to regulate pancreatic beta function. Thus, different organs such as skeletal muscle, adipose tissue, liver and others such as the brain, intestine, bone intervene in the regulation of insulin secretion.
I worked during my doctoral thesis and postdoctoral studies studying the secretome of skeletal muscle – myokines and extracellular vesicles – and their role in insulin secretion.
Since 2022, I have been working in a periodontal research laboratory, studying the mechanisms that associate periodontitis with type 2 diabetes. In particular, studying extracellular vesicles obtained from the periodontium of patients with periodontitis and evaluating their function in an animal model to study the metabolic changes they produce in the pancreas.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Doctorate in Medical Sciences, Pontificia Universidad Católica de Chile
… → 2016
Master, Master’s in Cellular Biology, Physiology, and Pathology, Université Paris Cité
… → 2010
University Degree, Biologist, Université Paris Cité
… → 2008
External positions
Post Doctorate, Centro Europeo de Estudio de la Diabetes
2 Jan 2018 → 31 Dec 2020
Open Keywords
- Diabetes
- Extracellular Vesicles
- Periodontitis
Research Lines
- Research Lines
- Periodontitis
- Type 2 Diabetes Mellitus
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Collaborations and top research areas from the last five years
Projects
- 1 Finished
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FAI INSCRIPCION CONGRESO - APO-CG-2023-28: INCREASED GINGIVAL CREVICULAR FLUID EXTRACELLULAR VESICLES ARE INVOLVED IN THE CROSSTALK BETWEEN PERIODONTITIS AND GESTATIONAL DIABETES
Mizgier, M. L. (Principal Investigator), Realini, O. (Co-Investigator), Bendek Viera, M. J. (Co-Investigator), Rojas Pérez, C. I. (Co-Investigator), Monje, S. (Co-Investigator), Figari, A. (Co-Investigator), Hernández, M. (Co-Investigator), Ramírez Lobos, V. (Co-Investigator), Illanes, S. (Co-Investigator), Busso, D. (Co-Investigator) & Chaparro, A. (Co-Investigator)
Universidad de los Andes Chile
4/09/23 → 30/12/23
Project: Research
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Proteomic Insights Into Gingival Crevicular Extracellular Vesicles in Periodontitis and Gestational Diabetes: An Exploratory Study
Mizgier, M. L., Nardocci, G., Ramírez, V., Bendek, M. J., Hernández, M., Rojas, C., Herrera, D., Kantarci, A., Kemp, M. W., Illanes, S. E. & Chaparro, A., 2024, (Accepted/In press) In: Journal of Clinical Periodontology.Research output: Contribution to journal › Article › peer-review
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Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction
Banerjee, S., Ghoshal, S., Stevens, J. R., McCommis, K. S., Gao, S., Castro-Sepulveda, M., Mizgier, M. L., Girardet, C., Ganesh Kumar, K., Galgani, J. E., Niehoff, M. L., Farr, S. A., Zhang, J. & Butler, A. A., 2 Oct 2020, In: Journal of Biological Chemistry. 295, 40, p. 13753-13768 16 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells
Arous, C., Mizgier, M. L., Rickenbach, K., Pinget, M., Bouzakri, K. & Wehrle-Haller, B., 4 Dec 2020, In: Journal of Biological Chemistry. 295, 49, p. 16510-16528 19 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Insights on the role of putative muscle-derived factors on pancreatic beta cell function
Mizgier, M. L., Fernández-Verdejo, R., Cherfan, J., Pinget, M., Bouzakri, K. & Galgani, J. E., 2019, In: Frontiers in Physiology. 10, AUG, 1024.Research output: Contribution to journal › Review article › peer-review
Open Access10 Scopus citations -
Skeletal muscle-released extracellular vesicles: State of the art
Rome, S., Forterre, A., Mizgier, M. L. & Bouzakri, K., 2019, In: Frontiers in Physiology. 10, JUL, 929.Research output: Contribution to journal › Review article › peer-review
Open Access97 Scopus citations