Projects per year
Personal profile
Professional Information
Studied Engineering in Molecular Biotechnology at Universidad de Chile and performed a PhD training joining the Molecular and Cellular Biology Program, with a mention in Immunology, at Dartmouth College (New Hampshire, USA), from which she graduaded in 2010. During these postgraduate studies, carried out at the laboratory of Dr. Randolph J. Noelle, she gained a solid training in the use of experimental models (murine) such as skin transplantation, tumor, among others, to study immune tolerance.
Additional Research Interests
In 2011, she returned to Chile and joined the Faculty of Medicine at Universidad de Chile thanks to the initiative Insertion of Advanced Human Capital into the Academia (CONICYT), ranking as the top selected applicant. This grant had as objective to insert the research line of cellular therapy for autoimmunity and tranplant rejection in this institution. From this year, she started her research team and in 2012 she began her independent scientific career when received the Initiation into Research grant from Fondecyt. In 2015 she joined Universidad de los Andes as Assistant Professor, and continues her investigation studying the role of T regulatory cells and their mechanisms of suppresion in transplantation tolerance funded by a Regular Fondecyt project. Currently, she is an academic of Facultad de Medicina, leading the Immunological Tolerance Group at Centro de Investigación e Innovación Biomédica at the same institution.
Education/Academic qualification
PhD, Dartmouth College
Award Date: 1 Jun 2011
External positions
President, Chilean Association of Immunology (ASOCHIN)
Nov 2023 → Nov 2025
Treasurer, Chilean Association of Immunology (ASOCHIN)
26 Sep 2019 → …
Network and Program Director, Art + Science Foundation
1 Jun 2019 → …
Vice-President, Chilean Association of Immunology (ASOCHIN)
1 Aug 2017 → 26 Sep 2019
Keywords
- Q Science (General)
- Immunology
- T regulatory cells
- Transplantation
- Tumor
Research Lines
- Research Lines
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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FONDECYT REGULAR - 1261754: IL-33 AS A MODULATOR OF TRYPTOPHAN METABOLISM: EMPHASIS ON THE CONTRIBUTION OF THE AHR SIGNALING ON FOXP3+ T REGULATORY CELLS IN A SKIN TRANSPLANTATION MODEL
Pino-Lagos, K. (Principal Investigator)
Agencia Nacional de Investigación y Desarrollo
1/04/26 → 31/03/30
Project: RESEARCH
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FONDECYT REGULAR - 1240604: BRAIN ASTROCYTE-DERIVED EXTRACELLULAR VESICLES ORCHESTRATE MACROPHAGE AND MICROGLIA POLARIZATION UNDER STRESS CONDITIONS THROUGH MIRNA-DEPENDENT REGULATION OF MACROPHAGE IMMUNOMETABOLISM REGULATOR (MACIR)
Wyneken, Ú. (Principal Investigator), Pino-Lagos, K. (Co-Investigator) & Hidalgo Fadic, Y. C. (Co-Investigator)
Agencia Nacional de Investigación y Desarrollo
1/04/24 → 31/03/28
Project: RESEARCH
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FAI PUENTE REGULAR - S/I: IL-33 COMO MODULADOR DEL METABOLISMO DEL TRIPTÓFANO, ÉNFASIS EN LINFOCITOS T REGULADORES EN UN MODELO MURINO DE TRASPLANTE DE PIEL
Pino-Lagos, K. (Principal Investigator)
1/01/24 → 31/12/26
Project: RESEARCH
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FONDECYT REGULAR - 1230875: REVEALING THE CONTRIBUTION OF MELANOMA-DERIVED CIRCULATING CELL-FREE MITOCHONDRIA IN THE FORMATION OF PREMETASTATIC NICHE IN LYMPH NODES AND THEIR IMPACT IN THE EARLY DEVELOPMENT OF METASTASIS
Alcayaga-Miranda, F. (Principal Investigator), Khoury, M. (Co-Investigator), Pino-Lagos, K. (Co-Investigator), Hidalgo, Y. (Co-Investigator) & González-Arriagada, W. A. (Co-Investigator)
Agencia Nacional de Investigación y Desarrollo
1/04/23 → 31/03/27
Project: RESEARCH
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FONDECYT REGULAR - 1210654: SMALL EXTRACELLULAR VESICLES OBTAINED FROM NEUROPILIN-1+ T REGULATORY CELLS AS A NOVEL TOOL FOR THE INDUCTION OF TRANSPLANTATION TOLERANCE
Pino-Lagos, K. (Principal Investigator) & Wyneken, Ú. (Co-Investigator)
Agencia Nacional de Investigación y Desarrollo
1/04/21 → 31/03/25
Project: RESEARCH
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CD4+FoxP3+ T regulatory cells subsets release small extracellular vesicles containing cell death-related proteins as potential mechanism of T cell suppression
Moya-Guzmán, M. J., de Solminihac, J., Carrasco-Loncharic, T., Kaehne, T. & Pino-Lagos, K., 2026, In: Frontiers in Immunology. 17, p. 1777669 1 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Downloads (Pure) -
Correction: A novel brain-to-gut communication pathway mediated by astrocyte-derived small extracellular vesicles modulates stress-induced intestinal inflammation (Molecular Psychiatry, (2025), 30, 12, (5710-5721), 10.1038/s41380-025-03289-2)
Yantén-Fuentes, L., Pizarro, M., Rojas, C., Pradenas, C., Méndez-Ruette, M., Corvalán, K., Bustos-Quevedo, G., Luarte, A., Batiz, L. F., Luz-Crawford, P., Pino-Lagos, K. & Wyneken, U., Feb 2026, In: Molecular Psychiatry. 31, 2, p. 1201 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
TGF-β-induced Tregs release extracellular vesicles that modulate CD4+ T-cell proliferation and phenotype in a Nrp1-dependent manner
Moya-Guzmán, M. J., González-Mienert, E., Pinto, C. & Pino-Lagos, K., 11 Apr 2026, In: ImmunoHorizons. 10, 4, vlag019.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
A novel brain-to-gut communication pathway mediated by astrocyte-derived small extracellular vesicles modulates stress-induced intestinal inflammation
Yantén-Fuentes, L., Pizarro, M., Rojas, C., Pradenas, C., Méndez-Ruette, M., Corvalán, K., Bustos-Quevedo, G., Luarte, A., Batiz, L. F., Luz-Crawford, P., Pino-Lagos, K. & Wyneken, U., Dec 2025, In: Molecular Psychiatry. 30, 12, p. 5710-5721 12 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Induced Treg-Derived Extracellular Vesicles Suppress CD4+ T-Cell-Mediated Inflammation and Ameliorate Bone Loss During Periodontitis Partly Through CD73/Adenosine-Dependent Immunomodulatory Mechanisms
Rojas, C., García, M., González-Osuna, L., Campos-Mora, M., de León, E. P., Sierra-Cristancho, A., Terraza, C., Cortez, C., Sansores-España, L. D., Carvajal, P., Bazoer, J., Peng, Q., Lawson, C., Smyth, L. A., Pino-Lagos, K. & Vernal, R., Jul 2025, In: Journal of Extracellular Vesicles. 14, 7, p. e70118 e70118.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations
Prizes
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Hermann Niemeyer Medal
Pino-Lagos, K. (Recipient) & Rojas, C. (Recipient), 2022
Prize: Other distinction
Activities
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Andrea Alice da Silva
Pino-Lagos, K. (Host)
Aug 2025 → Sep 2025Activity: Hosting a visitor › Hosting an academic visitor
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University of Chicago
Pino-Lagos, K. (Visiting researcher)
Dec 2023 → Feb 2024Activity: Visiting an external institution › Visiting an external academic institution
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Universidad de Manchester
Padilla Ruiz, C. (Estudiante visitante), Enrione Cáceres, J. (Supervisor) & Pino-Lagos, K. (Supervisor)
1 Feb 2023 → 1 Mar 2023Activity: Visiting an external institution › Visiting an external academic institution
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Mesenchymal stem cell-transferred mitochondria elicit an immune function reprogramming that entails T regulatory cell commitment and clinical improvement of graft vs host disease
Court, A. C. (Speaker), Le-Gatt, A. (Keynote speaker), Luz Crawford, P. A. (Speaker), Aliaga-Tobar, V. (Speaker), Batiz, L. F. (Speaker), Parra, E. (Speaker), Contreras, R. (Speaker), Ortúzar, M. I. (Speaker), Kurte, M. (Speaker), Elizondo-Vega, R. (Speaker), Maracaja-Coutinho, V. (Speaker), Pino-Lagos, K. (Speaker), Velarde, R. (Speaker), Khoury, M. (Speaker) & Figueroa, F. (Speaker)
2019Activity: Talk or presentation › Oral presentation
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King's College London
Pino-Lagos, K. (Visiting researcher)
1 Mar 2016 → 15 Mar 2016Activity: Visiting an external institution › Visiting an external academic institution
Courses
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DOCB1210 Avances Biotecnológicos en Medicina
J. Monteiro, L., Contardo, I., Nardocci, G., Acevedo, J. P., Khoury, M., Figueroa, F., Luz Crawford, P. A., Pino-Lagos, K., Wyneken, Ú., Alcayaga-Miranda, F., Enrione, J., Irarrazabal Muñoz, C. E., Illanes, S., Batiz, L. F., Chaparro, A., Haidar, Z. S., Díaz Calderón, P. & Sadarangani Khainey, A. P. 2/08/21 → …
Course
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NRC4144 Investigación Biomédica en la UANDES
Pino-Lagos, K., Contardo, I., Díaz Calderón, P., Luz Crawford, P. A., Wyneken, Ú., Illanes, S., Busso, D., J. Monteiro, L., Irarrazabal Muñoz, C. E. & Nardocci, G. 1/06/18 → …
Course