Projects per year
Personal profile
Professional Information
Dr. Francisco Espinoza Villegas is a Medical Doctor graduated from Universidad de los Andes (2006), with a specialization in Internal Medicine from the same institution. He furthered his training with a specialization in Rheumatology at the University of Montpellier, France, and a Research Fellowship at the University of California, San Diego, USA.
He currently serves as an Associate Professor at the Faculty of Medicine at UANDES and as a Rheumatologist at Clínica Universidad de los Andes.
Research interests
Dr. Espinoza leads research in the field of rheumatology, focusing on autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. His work also encompasses the application of cell therapies, including the use of umbilical cord-derived mesenchymal stem cells in the treatment of osteoarthritis. Additionally, he has been involved in studies on the immune response in COVID-19 patients, comparing their response with that of patients with rheumatoid arthritis.
Teaching
As an Associate Professor at the Faculty of Medicine at UANDES, Dr. Espinoza teaches courses in the Internal Medicine program, including the Internal Medicine Internship and Integrated Medical Clinics. His teaching approach integrates clinical practice with theoretical education, promoting active and student-centered learning.
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Collaborations and top research areas from the last five years
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IMPACT: CENTER OF INTERVENTIONAL MEDICINE FOR PRECISION AND ADVANCED CELLULAR THERAPY
Khoury, M. (Director), Alcayaga-Miranda, F. (Principal Investigator), Cuenca, J. (Principal Investigator), Acevedo, J. P. (Principal Investigator), Figueroa, F. (Principal Investigator), Luz Crawford, P. A. (Principal Investigator), Wyneken, Ú. (Principal Investigator), Illanes, S. (Principal Investigator), Batiz, L. F. (Associate Investigator), Busso, D. (Associate Investigator), J. Monteiro, L. (Associate Investigator), Nardocci, G. (Associate Investigator), Enrione, J. I. (Associate Investigator), Espinoza, F. (Associate Investigator), Valenzuela Bravo, M. T. (Associate Investigator) & Prieto, M. (Associate Investigator)
Agencia Nacional de Investigación y Desarrollo
1/11/21 → 31/10/26
Project: RESEARCH
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Desarrollo de un test en fluido salival como biomarcador de actividad y respuesta terapéutica en Artritis Reumatoide
Espinoza, R. (Principal Investigator) & Espinoza, F. (Principal Investigator)
Project: RESEARCH
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FONDEF IDeA I+D - CIENCIA APLICADA - ID21I10194: GLYCOSTEM-SEV: GENERACIÓN DE UN PRODUCTO ACELULAR BASADO EN NANOVESÍCULAS EXTRACELULARES DERIVADAS DE CÉLULAS MADRE MESENQUIMALES INDUCIDAS HACIA UN METABOLISMO GLICOLÍTICO PARA EL TRATAMIENTO DE LA OSTEOARTRITIS
Luz Crawford, P. A. (Principal Investigator), Alcayaga-Miranda, F. (Co-Investigator), Elizondo-Vega, R. J. (Co-Investigator), Espinoza, F. (Co-Investigator) & Matas, J. (Co-Investigator)
1/11/21 → 30/11/23
Project: INNOVACIÓN Y DESARROLLO
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Rol de la metil histona transferasa WHSC1 en la patogenia de la Osteoartritis
Espinoza, F. (Principal Investigator) & Espinoza, R. (Co-Investigator)
Universidad de los Andes Chile
12/08/13 → 29/11/14
Project: RESEARCH
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Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis
Figueroa-Valdés, A. I., Luz-Crawford, P., Herrera-Luna, Y., Georges-Calderón, N., García, C., Tobar, H. E., Araya, M. J., Matas, J., Donoso-Meneses, D., de la Fuente, C., Cuenca, J., Parra, E., Lillo, F., Varela, C., Cádiz, M. I., Vernal, R., Ortloff, A., Nardocci, G., Castañeda, V. & Adasme-Vidal, C. & 5 others, , Dec 2025, In: Journal of Nanobiotechnology. 23, 1, 13.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
A Phase I Dose-Escalation Clinical Trial to Assess the Safety and Efficacy of Umbilical Cord-Derived Mesenchymal Stromal Cells in Knee Osteoarthritis
Matas, J., García, C., Poblete, D., Vernal, R., Ortloff, A., Luque-Campos, N., Hidalgo, Y., Cuenca, J., Infante, C., Cadiz, M. I., Khoury, M., Luz-Crawford, P. & Espinoza, F., Mar 2024, In: Stem cells translational medicine. 13, 3, p. 193-203 11 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Efficacy of a single dose of cryopreserved human umbilical cord mesenchymal stromal cells for the treatment of knee osteoarthritis:a randomized, controlled, double-blind pilot study
Pico, O. A., Espinoza, F., Cádiz, M. I., Sossa, C. L., Becerra-Bayona, S. M., Salgado, M. C. C., Rodríguez, J. E. R., Cárdenas, O. F. V., Cure, J. M. Q., Khoury, M. & Arango-Rodríguez, M. L., 2024, In: Cytotherapy. 27, 2, p. 188-200 13 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Safety and efficacy of clinical-grade, cryopreserved menstrual blood mesenchymal stromal cells in experimental acute respiratory distress syndrome
Alcayaga-Miranda, F., Dutra Silva, J., Parada, N., Andrade da Silva, L. H., Ferreira Cruz, F., Utreras, Y., Hidalgo, Y., Cádiz, M. I., Tapia Limonchi, R., Espinoza, F., Bruhn, A., Khoury, M., R. M. Rocco, P. & Cuenca, J., 30 Jan 2023, In: Frontiers in Cell and Developmental Biology. 11, p. 1031331 1031331.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Soluble neuropilin-1 in gingival crevicular fluid is associated with rheumatoid arthritis: An exploratory case-control study
Prieto, D., González, C., Weber, L., Realini, O., Pino-Lagos, K., Bendek, M. J., Retamal, I., Beltrán, V., Riedemann, J. P., Espinoza, F. & Chaparro, A., 1 Apr 2021, In: Journal of Oral Biology and Craniofacial Research. 11, 2, p. 303-307 5 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations