Projects per year
Personal profile
Professional Information
I am a biologist and PhD from the University of Buenos Aires, Argentina. I live in Chile since 2005, working in research in the area of nutrition, metabolism and reproductive biology. I worked for 14 years at the Pontificia Universidad Católica de Chile, participating in research projects, undergraduate and postgraduate teaching and academic activities. Since November 2019 I am an Associate Professor at the Faculty of Medicine of the Universidad de los Andes, carrying out research, teaching and management tasks at the Center for Biomedical Research and Innovation.
Research interests
I direct the laboratory of Nutrition, Metabolism and Reproduction Laboratory. Its main aim is to understand, from a biomedical perspective, the influence of different aspects of maternal nutrition and metabolism on reproductive biology. We study both the physiological processes and the pathophysiological mechanisms that explain the impact of certain maternal conditions on reproduction. Our main studies are focused on the influence of adverse lipid and glucose metabolisms and of subclinical micronutrient deficiencies on female fertility and pregnancy outcome. We are also interested in understanding fetal programming due to malnutrition.
Education/Academic qualification
PhD, Ciencias Biológicas, Universidad de Buenos Aires
1999 → 2005
University Degree, Licenciada en Ciencias Biológicas, Universidad de Buenos Aires
… → 1997
External positions
Presidenta, Sociedad Chilena de Reproducción y Desarrollo
2023 → 2024
Integrante Panel de Revisores Grupo de Estudio Medicina G1, para Proyectos FONDECYT , Agencia Nacional de Investigación y Desarrollo
2021
Directora, Sociedad Latinoamericana de Interacción Materno Fetal
2021 → 2024
Profesor, Pontificia Universidad Católica de Chile
1 Jan 2013 → 1 Oct 2019
Adjunct Researcher, Pontificia Universidad Católica de Chile
2010 → 2013
Postdoc, Pontificia Universidad Católica de Chile
2005 → 2010
Keywords
- RG Gynecology and obstetrics
- Reproduction
- Pregnancy
- Metabolism
- Fertility
- Neural tube defects
- Q Science (General)
- Physiology
- Cell biology
- Molecular biology
Research Lines
- Research Lines
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 2 Zero Hunger
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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IMPACT: CENTER OF INTERVENTIONAL MEDICINE FOR PRECISION AND ADVANCED CELLULAR THERAPY (IMPACT)
Khoury, M. (Director), Alcayaga-Miranda, F. (Principal Investigator), Cuenca, J. (Principal Investigator), Acevedo, J. P. (Principal Investigator), Figueroa, F. (Principal Investigator), Luz Crawford, P. A. (Principal Investigator), Wyneken, Ú. (Principal Investigator), Illanes, S. (Principal Investigator), Batiz, L. F. (Associate Investigator), Busso, D. (Associate Investigator), J. Monteiro, L. (Associate Investigator), Nardocci, G. (Associate Investigator), Enrione, J. I. (Associate Investigator), Espinoza, F. (Associate Investigator), Valenzuela Bravo, M. T. (Associate Investigator) & Prieto, M. L. (Associate Investigator)
Agencia Nacional de Investigación y Desarrollo
1/11/21 → 31/10/26
Project: INNOVACIÓN Y DESARROLLO
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FAI INSCRIPCIÓN CONGRESOS - APO-CG-2023-28: INCREASED GINGIVAL CREVICULAR FLUID EXTRACELLULAR VESICLES ARE INVOLVED IN THE CROSSTALK BETWEEN PERIODONTITIS AND GESTATIONAL DIABETES
Mizgier, M. L. (Principal Investigator), Realini, O. (Co-Investigator), Bendek Viera, M. J. (Co-Investigator), Rojas Pérez, C. I. (Co-Investigator), Monje, S. (Co-Investigator), Figari, A. (Co-Investigator), Hernández, M. (Co-Investigator), Ramírez Lobos, V. (Co-Investigator), Illanes, S. (Co-Investigator), Busso, D. (Co-Investigator) & Chaparro, A. (Co-Investigator)
Universidad de los Andes Chile
4/09/23 → 30/12/23
Project: RESEARCH
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FONDECYT REGULAR - 1221376: UNCOVERING MECHANISMS CONTRIBUTING TO EXCENCEPHALY AND ITS PREVENTION BY MATERNAL VITAMIN E SUPPLEMENTATION IN HDL RECEPTOR SR-B1 KO MOUSE EMBRYOS
Busso, D. (Principal Investigator)
Agencia Nacional de Investigación y Desarrollo
1/04/22 → 31/03/26
Project: RESEARCH
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FONDECYT REGULAR - 1211471: THE PATHOGENIC VICIOUS CYCLE BETWEEN PERIODONTITIS AND GESTATIONAL DIABETES MELLITUS: COMMUNICATION VIA BACTERIAL TRANSLOCATION AND EXTRACELLULAR VESICLES
Chaparro, A. (Principal Investigator), Busso, D. (Co-Investigator), Illanes, S. (Co-Investigator), Ramírez Lobos, V. (Co-Investigator), Hernández Ríos, E. (Co-Investigator) & Hoare, A. (Co-Investigator)
Agencia Nacional de Investigación y Desarrollo
1/04/21 → 31/03/25
Project: RESEARCH
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Lipophilic statins inhibit the exosome-mediated and obesity-induced cancer progression: the relevance of reestablishing natural killer cell immune surveillance to delay recurrence and improve future therapeutic outcomes in high-grade serous ovarian cancer
Cuello, M. (Principal Investigator) & Busso, D. (Co-Investigator)
1/03/20 → 28/02/23
Project: RESEARCH
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Altered brain vascularization and transcriptional changes in embryos lacking ABCA1 support a role of cholesterol in brain angiogenesis
Becerra, B., Ramírez-Herrera, O., Barrios, J., Madrid, J., Calfunao, S., Saavedra, F., Romo-Toledo, P., Juárez-Balarezo, J., Casanova-Maldonado, I., Arnold, T., Palma, V., Busso, D. & Santander, N., 2026, In: Frontiers in Cell and Developmental Biology. 14, p. 1 - 12 12 p., 1783696.Research output: Contribution to journal › Article › peer-review
Open Access -
Genetic background influences susceptibility to exencephaly in Scavenger receptor Class B type 1-deficient mouse embryos
Romero-Muñoz, C., Romo-Toledo, P., Belledonne, G. & Busso, D., Jan 2026, In: Placenta. 173, p. 87-94 8 p.Research output: Contribution to journal › Review article › peer-review
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Lipid Remodeling in Mouse SR-B1-Deficient Embryos with Oxidative Stress-Associated Neural Tube Defects
Quiroz, A., Santander, N., Nicolás, G. D. E., Leung, K. Y. & Busso, D., May 2026, In: Antioxidants. 15, 5, 634.Research output: Contribution to journal › Article › peer-review
Open Access -
Deficiency of the Tangier Disease Gene Abca1 Is Associated With Microglial Defects in Mice
Celis, T., Ramírez-Herrera, O., Barraza, M., Calfunao, S., Saavedra, F., Romo-Toledo, P., Busso, D. & Santander, N., Dec 2025, In: International Journal of Developmental Neuroscience. 85, 8, p. e70074 e70074.Research output: Contribution to journal › Article › peer-review
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Epidemiological insights into neural tube and orofacial malformations in Chile using data from the National Registry of Congenital Anomalies (RENACH)
Busso, D., Jiménez, F., González, M. J., Cárcamo, M. & Mosso, L., Dec 2025, In: BMC Pediatrics. 25, 1, p. 862 862.Research output: Contribution to journal › Article › peer-review
Open Access
Activities
- 3 Visiting an external academic institution
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Medical University of Graz
Busso, D. (Visiting researcher)
2016 → …Activity: Visiting an external institution › Visiting an external academic institution
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Medical University of Graz
Busso, D. (Visiting researcher)
2012 → …Activity: Visiting an external institution › Visiting an external academic institution
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Massachusetts Institute of Technology
Busso, D. (Visiting researcher)
2011Activity: Visiting an external institution › Visiting an external academic institution
Courses
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DOCB1110 Biología Celular y Molecular en Biomedicina
J. Monteiro, L., Nardocci, G., Batiz, L. F., Busso, D., Acevedo, J. P., Luz Crawford, P. A. & Wyneken, Ú. 22/03/21 → 30/06/21
Course
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DOCB3364 Tópicos Avanzados en Biomedicina: Contenido Optativo
J. Monteiro, L., Busso, D., Illanes, S., Batiz, L. F., Chaparro, A. & Monckeberg, M. 20/08/20 → 14/12/20
Course
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NRC4144 Investigación Biomédica en la UANDES
Pino-Lagos, K., Contardo, I., Díaz Calderón, P., Luz Crawford, P. A., Wyneken, Ú., Illanes, S., Busso, D., J. Monteiro, L., Irarrazabal Muñoz, C. E. & Nardocci, G. 1/06/18 → …
Course