Projects per year
Previously to be an independent investigator Dr. Irarrázabal participate in several investigations in the Universidad de Chile. One of his most interesting research was to clarify the mechanisms involved in the specificity of the amino acid transporter y+L system in the human erythrocyte. Besides, he participates in an initiative from the Organization of American States to disseminate the biotechnology interaction between academics and industry. He was co-editor of two books in this area. During his doctoral thesis, he was awarded with two government support grants. The doctoral thesis help to identifies a p53 gene polymorphisms in humans associated with lung cancer susceptibility. After finished the Ph.D. program in the Universidad de Chile, he moved to Bethesda City in the U.S.A. to carry out his postdoc training in renal physiology in the National Institutes of Health (NIH-USA) under the supervision of Dr. Maurice Burg. In NIH, his contribution provided important evidence to understand how the cells survived in hypertonic condition in kidney, helping to clarify the knowledge of the renal function and the osmotic stress response signaling pathway. Right now, he is a full professor and Chief of the Laboratory of Integrative and Molecular Physiology in the Universidad de los Andes (UANDES) in Chile. He has over 30 publications that have been cited over 500 times, and his publication H-index is 18 and has been serving as an editorial board member of reputed Journals. In the UANDES, he has worked in more than 10 research projects generating two patents for clinical application in hypoxia and renal damage.
Fellow Post-Doc, The National Institutes of Health
25 Jun 2002 → 25 Jun 2007
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Emerging new role of NFAT5 in inducible nitric oxide synthase in response to hypoxia in mouse embryonic fibroblast cellsSerman, Y., Fuentealba, R. A., Pasten, C., Rocco, J., Ko, B. C. B., Carrión, F. & Irarrazabal Muñoz, C. E., 2019, In: American Journal of Physiology - Cell Physiology. 317, 1, p. C31-C38
Research output: Contribution to journal › Article › peer-reviewOpen Access1 Scopus citations
L-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in micePasten, C., Alvarado, C., Rocco, J., Contreras, L., Aracena, P., Liberona, J., Suazo, C., Michea, L. & Irarrazabal Muñoz, C. E., Apr 2019, In: American Journal of Physiology - Renal Physiology. 316, 4, p. F624-F634
Research output: Contribution to journal › Article › peer-reviewOpen Access3 Scopus citations
Oxidative damage and nitric oxide synthase induction by surgical uteroplacental circulation restriction in the rabbit fetal heartFigueroa, H., Alvarado, C., Cifuentes, J., Lozano, M., Rocco, J., Cabezas, C., Illanes, S., Eixarch, E., Hernández-Andrade, E., Gratacós, E. & Irarrazabal Muñoz, C. E., May 2017, In: Prenatal Diagnosis. 37, 5, p. 453-459 7 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access2 Scopus citations
Differential TLR activation of murine mesenchymal stem cells generates distinct immunomodulatory effects in EAEVega-Letter, A. M., Kurte, M., Fernández-O'Ryan, C., Gauthier-Abeliuk, M., Fuenzalida, P., Moya-Uribe, I., Altamirano, C., Figueroa, F., Irarrazabal Muñoz, C. E. & Carrión, F., 10 Oct 2016, In: Stem Cell Research and Therapy. 7, 1, p. 1-12 12 p., 150.
Research output: Contribution to journal › Article › peer-reviewOpen Access21 Scopus citations
Ugarte, F., Irarrazabal Muñoz, C. E., Oh, J., Dettmar, A., Ceballos, M. L., Rojo, A., Ibacache, M. J., Suazo, C., Lozano, M., Delgado, I., Cavada, G., Azocar, M., Delucchi, A. & Cano, F., 8 Jan 2016, In: Pediatric Nephrology. 31, 6, p. 965-974 10 p.
Research output: Contribution to journal › Article › peer-review3 Scopus citations