Research output per year
Research output per year
Personal profile
Professional Information
In recent years, I have dedicated my research to the fields of anti-tumor immunology and melanoma immunotherapy. My work specifically focuses on the role of CD8+ T lymphocytes in the anti-tumor response, the development of T-cell exhaustion, and tumor mitochondrial transfer as a mechanism of immune evasion
Research interests
Antitumoral immunity, immunotherapy and immunometabolism.
Teaching
Antitumoral immunity, immunotherapy and flow cytometry
Education/Academic qualification
PhD, Biomedical Sciences, Universidad de Chile
2017 → 2022
Master, Biomedical Sciences, Universidad de Chile
2012 → 2015
University Degree, Molecular Biotechnology engineer, Universidad de Chile
2004 → 2011
Open Keywords
- Cancer immunology
- T cells
- Mitochondria
Research Lines
- Research Lines
- Antitumoral Immunity and immunotherapy
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
- 7 Article
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Melanoma cells release dysfunctional mitochondria to the tumor microenvironment and circulation in association with tumor progression
Georges-Calderón, N., Fuentes, C., Hidalgo, Y., Grunenwald, F., Corrales-Bermúdez, J., Figueroa-Valdés, A. I., Ramírez-Pereira, M., Arriagada, G., Bustos, F. J., Ahumada-Marchant, C., López, M. & Alcayaga-Miranda, F., Jan 2026, In: Cancer Letters. 647, 218457.Research output: Contribution to journal › Article › peer-review
Open Access -
Phase I trial of a heat-conditioned tumor lysate vaccine (TRIMELVax) in anti-PD-1 refractory melanoma: safety and immunological aspects (NCT06556004)
Estay, R., Cortés, A., Müller, B., Tempio, F., Merino, C., Fuentes, C., Rebolledo, A., Ramírez, N., Contalba, P., Bustos, K., Pereda, C., Gleisner, M. A., Flores, I., González, F. E., Tittarelli, A., Achour, A., Hidalgo, S., Lladser, Á., Becker, M. I. & Salazar-Onfray, F. & 1 others, , 2026, In: British Journal of Cancer. 135, 3, p. 436-444 9 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity
Flores-Santibañez, F., Rennen, S., Fernández, D., De Nolf, C., Van De Velde, E., Gaete González, S., Fuentes, C., Moreno, C., Figueroa, D., Lladser, Á., Iwawaki, T., Bono, M. R., Janssens, S. & Osorio, F., 2023, In: Frontiers in Immunology. 14, 1209588.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Dysregulated Immune Responses in COVID-19 Patients Correlating With Disease Severity and Invasive Oxygen Requirements
García-González, P., Tempio, F., Fuentes, C., Merino, C., Vargas, L., Simon, V., Ramirez-Pereira, M., Rojas, V., Tobar, E., Landskron, G., Araya, J. P., Navarrete, M., Bastias, C., Tordecilla, R., Varas, M. A., Maturana, P., Marcoleta, A. E., Allende, M. L., Naves, R. & Hermoso, M. A. & 4 others, , 21 Oct 2021, In: Frontiers in Immunology. 12, 769059.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
A heat-shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells inhibiting tumor growth
Gleisner, M. A., Pereda, C., Tittarelli, A., Navarrete, M., Fuentes, C., Ávalos, I., Tempio, F., Araya, J. P., Becker, M. I., González, F. E., López, M. N. & Salazar-Onfray, F., 20 Jul 2020, In: Journal for ImmunoTherapy of Cancer. 8, 2, e000999.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations