Projects per year
Personal profile
Professional Information
Dr. Úrsula Wyneken Hempel is a Biochemist, holding a Bachelor's degree in Biochemistry, a Master's degree in Neurobiology and Behavioral Sciences, and a Ph.D. in Biomedical Sciences, all obtained from the University of Chile.
Since 1996, she has been a faculty member at the Faculty of Medicine at Universidad de los Andes, where she teaches undergraduate and graduate courses in Neurosciences.
She also leads the Extracellular Vesicles in Nervous System Pathologies Research Group and directs the Neurosciences Program at UANDES.
Her research focuses on communication between the Central Nervous System and the periphery through extracellular vesicles, especially under stress conditions.
She has been recognized for her outstanding research work, receiving awards such as the one granted by Banco Santander and El Mercurio in 2016 for her studies on the effects of maternal stress on fetal neuronal development.
Research interests
Dr. Wyneken specializes in studying extracellular vesicles as mediators in communication between the Central Nervous System and the periphery, particularly under stress conditions. Her work focuses on the role these vesicles play in nervous system health and disease.
One of her main research areas is how extracellular vesicles participate in cell communication within neurological pathologies, exploring their involvement in various nervous system diseases. This approach aims to better understand the underlying mechanisms of these conditions to develop new diagnostic and therapeutic strategies.
Additionally, she develops methods to identify biomarkers in plasma-derived extracellular vesicles, aiming to improve the diagnosis of psychiatric disorders such as bipolar disorder and depression. She also investigates how maternal stress during pregnancy alters circulating vesicles and the impact on fetal neuronal development, contributing to knowledge about prenatal stress effects on mental health.
Teaching
Teaches courses in the field of Neurosciences at the Faculty of Medicine of Universidad de los Andes, in both undergraduate and graduate programs. She also leads the Biomedical Research Immersion Program (PiiB), which allows medical students to join research groups, fostering the training of future professionals with a strong foundation in scientific research.
Education/Academic qualification
PhD, Ciencias Biomédicas, Universidad de Chile
… → 1996
University Degree, Bioquímica, Universidad de Chile
Research Lines
- Research Lines
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Collaborations and top research areas from the last five years
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FONDECYT REGULAR - 1240604: BRAIN ASTROCYTE-DERIVED EXTRACELLULAR VESICLES ORCHESTRATE MACROPHAGE AND MICROGLIA POLARIZATION UNDER STRESS CONDITIONS THROUGH MIRNA-DEPENDENT REGULATION OF MACROPHAGE IMMUNOMETABOLISM REGULATOR (MACIR)
Wyneken, Ú. (Principal Investigator), Pino-Lagos, K. (Co-Investigator) & Hidalgo, Y. (Co-Investigator)
Agencia Nacional de Investigación y Desarrollo
1/04/24 → 31/03/28
Project: RESEARCH
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IMPACT: CENTER OF INTERVENTIONAL MEDICINE FOR PRECISION AND ADVANCED CELLULAR THERAPY
Khoury, M. (Director), Alcayaga-Miranda, F. (Principal Investigator), Cuenca, J. (Principal Investigator), Acevedo, J. P. (Principal Investigator), Figueroa, F. (Principal Investigator), Luz Crawford, P. A. (Principal Investigator), Wyneken, Ú. (Principal Investigator), Illanes, S. (Principal Investigator), Batiz, L. F. (Associate Investigator), Busso, D. (Associate Investigator), J. Monteiro, L. (Associate Investigator), Nardocci, G. (Associate Investigator), Enrione, J. I. (Associate Investigator), Espinoza, F. (Associate Investigator), Valenzuela Bravo, M. T. (Associate Investigator) & Prieto, M. (Associate Investigator)
Agencia Nacional de Investigación y Desarrollo
1/11/21 → 31/10/26
Project: RESEARCH
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Uso de exosomas de células madre mesenquimales en el tratamiento de la epilepsia: prevención de muerte neuronal
Wyneken, Ú. (Principal Investigator)
Project: RESEARCH
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DESAFÍO GLOBAL EN LONGEVIDAD SALUDABLE - S/I: CATCH IT EARLY: REVOLUTIONIZING DIFFERENTIAL MILD COGNITIVE IMPAIRMENT DIAGNOSIS WITH CELLULAR SENSORS FOR EARLY DETECTION OF ALZHEIMER’S DISEASE AND NEURODEGENERATION
Wyneken, Ú. (Director), Luarte Navarro, A. E. (Alternate Director), Ramírez Lobos, V. (Principal Investigator) & Perez, C. A. (Principal Investigator)
Agencia Nacional de Investigación y Desarrollo
1/12/23 → 30/12/24
Project: INNOVACIÓN Y DESARROLLO
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FONDEF IDeA I+D - ID24I10081: DEVELOPMENT OF A CLINICAL AND BIOMARKER BASED DIAGNOSTIC ALGORITHM TO IMPROVE THE DIFFERENTIAL DIAGNOSIS OF MAJOR DEPRESSIVE DISORDER AND BIPOLAR DISORDER DURING DEPRESSIVE EPISODES
Prieto, M. (Principal Investigator) & Wyneken, Ú. (Co-Investigator)
2/01/23 → 31/12/24
Project: INNOVACIÓN Y DESARROLLO
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A novel brain-to-gut communication pathway mediated by astrocyte-derived small extracellular vesicles modulates stress-induced intestinal inflammation
Yantén-Fuentes, L., Pizarro, M., Rojas, C., Pradenas, C., Méndez-Ruette, M., Corvalán, K., Bustos, G., Luarte, A., Batiz, L. F., Luz-Crawford, P., Pino-Lagos, K. & Wyneken, U., 2025, (Accepted/In press) In: Molecular Psychiatry.Research output: Contribution to journal › Article › peer-review
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Bulk serum extracellular vesicles from stressed mice show a distinct proteome and induce behavioral and molecular changes in naive mice
Monteleone, M. C., Billi, S. C., Abarzúa-Catalán, L., Henzi, R., Fernández, E. M., Kaehne, T., Wyneken, U. & Brocco, M. A., 1 Aug 2024, In: PLoS ONE. 19, 8, e0308976.Research output: Contribution to journal › Article › peer-review
Open Access -
Editorial: Medicinal drugs, the effect on memories and beyond
Moreira-Rodrigues, M., Ampuero, E. & Wyneken, U., 2024, In: Frontiers in Pharmacology. 15, 1471049.Research output: Contribution to journal › Editorial
Open Access2 Scopus citations -
Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice
Acuña-Catalán, D., Shah, S., Wehrfritz, C., Nomura, M., Acevedo, A., Olmos, C., Quiroz, G., Huerta, H., Bons, J., Ampuero, E., Wyneken, U., Sanhueza, M., Arancibia, F., Contreras, D., Cárdenas, J. C., Morales, B., Schilling, B., Newman, J. C. & González-Billault, C., 18 Jun 2024, In: Cell Reports Medicine. 5, 6, p. 101593 101593.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus
Sánchez-Rubio, M., Abarzúa-Catalán, L., del Valle, A., Méndez-Ruette, M., Salazar, N., Sigala, J., Sandoval, S., Godoy, M. I., Luarte, A., Monteiro, L. J., Romero, R., Choolani, M. A., Wyneken, Ú., Illanes, S. E. & Bátiz, L. F., Dec 2024, In: Biological Research. 57, 1, 70.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Activities
- 3 Oral presentation
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The M105I mutation of alpha-SNAP leads to increased levels of pAMPK affecting the mitochondrial homeostasis and the balance between proliferation and differentiation of neural stem/progenitor cells
Henzi, R. (Keynote speaker), Bustamante, F. A. (Speaker), Méndez, M. (Speaker), Wyneken, Ú. (Speaker) & Batiz, L. F. (Speaker)
2021Activity: Talk or presentation › Oral presentation
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Maternal brain-to-fetal brain communication mediated by small extracellular vesicles: Possible role in prenatal stress
Abarzua-Catalan, L. (Speaker), Henzi, R. (Speaker), Wyneken, Ú. (Speaker), Illanes, S. (Speaker) & Batiz, L. F. (Keynote speaker)
2019Activity: Talk or presentation › Oral presentation
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SUMOylation determines the protein cargo of astrocyte-derived small extracellular vesicles
Méndez, M. (Keynote speaker), Fernández, A. (Speaker), Batiz, L. F. (Speaker), Henzi, R. (Speaker), Rojas-Fernández, A. (Speaker) & Wyneken, Ú. (Speaker)
2019Activity: Talk or presentation › Oral presentation
Courses
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DOCB1110 Biología Celular y Molecular en Biomedicina
J. Monteiro, L., Nardocci, G., Batiz, L. F., Busso, D., Acevedo, J. P., Luz Crawford, P. A. & Wyneken, Ú. 22/03/21 → 30/06/21
Course
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DOCB1210 Avances Biotecnológicos en Medicina
Course
Press/Media
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Universidad de los Andes se adjudica IDeA I+D con foco en Ingeniería y Biomedicina
27/03/24
1 item of Media coverage
Press/Media: Vinculación con el medio a través de medios de comunicación social