Projects per year
Personal profile
Research Interests
Neuroscientist interested in the study of stress effects on the central nervous system. In particular, we have been focusing on molecular pathways that participate in the axis from the brain to peripheral organs and that contribute to the high co-morbidity among stress-induced pathologies. In that line, we also study peripheral biomarkers that are associated to neuropsychiatric disorders.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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FONDECYT REGULAR - 1240604: Brain astrocyte-derived extracellular vesicles orchestrate macrophage and microglia polarization under stress conditions through miRNA-dependent regulation of macrophage immunometabolism regulator (MACIR)
Wyneken, Ú. (Principal Investigator), Pino-Lagos, K. (Co-Investigator) & Hidalgo, Y. (Co-Investigator)
Agencia Nacional de Investigación y Desarrollo (ANID), Chile
1/04/24 → 31/03/28
Project: Research
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Center of Interventional Medicine for Precision and Advanced Cellular Therapy (IMPACT)
Khoury, M. (Director), Alcayaga-Miranda, F. (Principal Investigator), Cuenca, J. (Principal Investigator), Acevedo, J. P. (Principal Investigator), Figueroa, F. (Principal Investigator), Luz Crawford, P. A. (Principal Investigator), Wyneken, Ú. (Principal Investigator), Illanes, S. (Principal Investigator), Batiz, L. F. (Associate Investigator), Busso, D. (Associate Investigator), J. Monteiro, L. (Associate Investigator), Nardocci, G. (Associate Investigator), Enrione, J. I. (Associate Investigator), Espinoza, F. (Associate Investigator), Valenzuela Bravo, M. T. (Associate Investigator) & Prieto, M. (Associate Investigator)
Agencia Nacional de Investigación y Desarrollo (ANID), Chile
1/11/21 → 31/10/26
Project: Research
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FONDECYT REGULAR - 1210654: SMALL EXTRACELLULAR VESICLES OBTAINED FROM NEUROPILIN-1+ T REGULATORY CELLS AS A NOVEL TOOL FOR THE INDUCTION OF TRANSPLANTATION TOLERANCE
Pino-Lagos, K. (Principal Investigator) & Wyneken, Ú. (Co-Investigator)
Agencia Nacional de Investigación y Desarrollo (ANID), Chile
1/04/21 → 31/03/25
Project: Research
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FONDECYT REGULAR - 1211384: PRENATAL STRESS: MATERNAL ASTROCYTE-DERIVED EXTRACELLULAR VESICLES AS A NOVEL STRESS-TRANSFER MECHANISM CONTRIBUTING TO ADVERSE OFFSPRING NEURODEVELOPMENT
Batiz, L. F., Nardocci, G., Wyneken, Ú., Illanes, S., J. Monteiro, L. & Caradeux, J.
Agencia Nacional de Investigación y Desarrollo (ANID), Chile
1/04/21 → 31/03/25
Project: Research
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Bulk serum extracellular vesicles from stressed mice show a distinct proteome and induce behavioral and molecular changes in naive mice
Monteleone, M. C., Billi, S. C., Abarzúa-Catalán, L., Henzi, R., Fernández, E. M., Kaehne, T., Wyneken, U. & Brocco, M. A., 1 Aug 2024, In: PLoS ONE. 19, 8, e0308976.Research output: Contribution to journal › Article › peer-review
Open Access -
Editorial: Medicinal drugs, the effect on memories and beyond
Moreira-Rodrigues, M., Ampuero, E. & Wyneken, U., 2024, In: Frontiers in Pharmacology. 15, 1471049.Research output: Contribution to journal › Editorial
Open Access -
Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice
Acuña-Catalán, D., Shah, S., Wehrfritz, C., Nomura, M., Acevedo, A., Olmos, C., Quiroz, G., Huerta, H., Bons, J., Ampuero, E., Wyneken, U., Sanhueza, M., Arancibia, F., Contreras, D., Cárdenas, J. C., Morales, B., Schilling, B., Newman, J. C. & González-Billault, C., 18 Jun 2024, In: Cell Reports Medicine. 5, 6, 101593.Research output: Contribution to journal › Article › peer-review
Open Access -
Methadone directly impairs central nervous system cells in vitro
De Gregorio, C., Gallardo, J., Berríos-Cárcamo, P., Handy, Á., Santapau, D., González-Madrid, A., Ezquer, M., Morales, P., Luarte, A., Corvalán, D., Wyneken, Ú. & Ezquer, F., Dec 2024, In: Scientific Reports. 14, 1, 16978.Research output: Contribution to journal › Article › peer-review
Open Access -
Sumoylation in astrocytes induces changes in the proteome of the derived small extracellular vesicles which change protein synthesis and dendrite morphology in target neurons
Fernandez, A., Corvalan, K., Santis, O., Mendez-Ruette, M., Caviedes, A., Pizarro, M., Gomez, M. T., Batiz, L. F., Landgraf, P., Kahne, T., Rojas-Fernandez, A. & Wyneken, U., 15 Jan 2024, In: Brain Research. 1823, p. 1-12 12 p., 148679.Research output: Contribution to journal › Article › peer-review
Open Access
Activities
- 3 Oral presentation
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The M105I mutation of alpha-SNAP leads to increased levels of pAMPK affecting the mitochondrial homeostasis and the balance between proliferation and differentiation of neural stem/progenitor cells
Roberto Henzi (Keynote speaker), Felipe A. Bustamante (Speaker), Maxs Méndez (Speaker), Úrsula Wyneken (Speaker) & Luis Federico Batiz (Speaker)
2021Activity: Talk or presentation › Oral presentation
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SUMOylation determines the protein cargo of astrocyte-derived small extracellular vesicles
Maxs Méndez (Keynote speaker), Anllely Fernández (Speaker), Luis Federico Batiz (Speaker), Roberto Henzi (Speaker), Alejandro Rojas-Fernández (Speaker) & Úrsula Wyneken (Speaker)
2019Activity: Talk or presentation › Oral presentation
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Maternal brain-to-fetal brain communication mediated by small extracellular vesicles: Possible role in prenatal stress
Lorena Abarzua-Catalan (Speaker), Roberto Henzi (Speaker), Úrsula Wyneken (Speaker), Sebastián Illanes (Speaker) & Luis Federico Batiz (Keynote speaker)
2019Activity: Talk or presentation › Oral presentation
Courses
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DOCB1110 Biología Celular y Molecular en Biomedicina
J. Monteiro, L., Nardocci, G., Batiz, L. F., Busso, D., Acevedo, J. P., Luz Crawford, P. A. & Wyneken, Ú. 22/03/21 → 30/06/21
Course
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DOCB1210 Avances Biotecnológicos en Medicina
Course