Medicina

J. Monteiro, L. (Principal Investigator), Donoso, M. B. (Co-Investigator), Vega-Letter, A. M. (Co-Investigator), Illanes, S. (Co-Investigator) & Luz Crawford, P. A. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/23 → 31/03/27

Project: Research

FONDECYT REGULAR - 1230875: REVEALING THE CONTRIBUTION OF MELANOMA-DERIVED CIRCULATING CELL-FREE MITOCHONDRIA IN THE FORMATION OF PREMETASTATIC NICHE IN LYMPH NODES AND THEIR IMPACT IN THE EARLY DEVELOPMENT OF METASTASIS

Alcayaga-Miranda, F. (Principal Investigator), Khoury, M. (Co-Investigator), Pino-Lagos, K. (Co-Investigator), Hidalgo, Y. (Co-Investigator) & González-Arriagada, W. A. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/23 → 31/03/27

Project: Research

FONDECYT POSTDOCTORADO - 3220204: TRANSFERENCIA MITOCONDRIAL DESDE CÉLULAS MADRE MESENQUIMALES COMO UNA NUEVA ALTERNATIVA TERAPÉUTICA PARA DESÓRDENES DEL NEURODESARROLLO: RELEVANCIA EN EL RESCATE METABÓLICO Y FUNCIONAL DE CÉLULAS MADRE NEURALES

Luz Crawford, P. A. (Sponsoring Researcher) & Bustamante, F. A. (Postdoctoral Researcher)

Agencia Nacional de Investigación y Desarrollo (ANID)

15/04/22 → 14/04/25

Project: Research

FONDECYT REGULAR - 1221376: UNCOVERING MECHANISMS CONTRIBUTING TO EXCENCEPHALY AND ITS PREVENTION BY MATERNAL VITAMIN E SUPPLEMENTATION IN HDL RECEPTOR SR-B1 KO MOUSE EMBRYOS

Busso, D. (Principal Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/22 → 31/03/26

Project: Research

FONDECYT INICIACIÓN - 11220601: EXPLORING THE CONTRIBUTION OF ASTROCYTE-DERIVED EXTRACELLULAR VESICLES TO CONTROL AXONAL PROTEIN SYNTHESIS BY MICRORNA TRANSFER

Luarte Navarro, A. E. (Principal Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

15/03/22 → 14/03/25

Project: Research

IMPACT: CENTER OF INTERVENTIONAL MEDICINE FOR PRECISION AND ADVANCED CELLULAR THERAPY

Khoury, M. (Director), Alcayaga-Miranda, F. (Principal Investigator), Cuenca, J. (Principal Investigator), Acevedo, J. P. (Principal Investigator), Figueroa, F. (Principal Investigator), Luz Crawford, P. A. (Principal Investigator), Wyneken, Ú. (Principal Investigator), Illanes, S. (Principal Investigator), Batiz, L. F. (Associate Investigator), Busso, D. (Associate Investigator), J. Monteiro, L. (Associate Investigator), Nardocci, G. (Associate Investigator), Enrione, J. I. (Associate Investigator), Espinoza, F. (Associate Investigator), Valenzuela Bravo, M. T. (Associate Investigator) & Prieto, M. (Associate Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/11/21 → 31/10/26

Project: Research

FONDECYT REGULAR - 1211384: PRENATAL STRESS: MATERNAL ASTROCYTE-DERIVED EXTRACELLULAR VESICLES AS A NOVEL STRESS-TRANSFER MECHANISM CONTRIBUTING TO ADVERSE OFFSPRING NEURODEVELOPMENT

Batiz, L. F. (Principal Investigator), Nardocci, G. (Co-Investigator), Wyneken, Ú. (Co-Investigator), Illanes, S. (Co-Investigator), J. Monteiro, L. (Co-Investigator) & Caradeux, J. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/21 → 31/03/25

Project: Research

INVESTIGATING THE EFFECT OF MAVS ENRICHED MITOCHONDRIAL TRANSPLANTATION ON INTRACELLULAR ANTIVIRAL IMMUNITY AND THEIR RESTORATIVE AND IMMUNOMODULATORY EFFECTS IN A VIRALINDUCED ACUTE LUNG INJURY MODEL

Cuenca, J. (Principal Investigator), Alcayaga-Miranda, F. (Co-Investigator), Khoury, M. (Co-Investigator), Hidalgo, Y. (Co-Investigator) & Kurte, M. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/21 → 31/03/25

Project: Research

FONDECYT REGULAR - 1210654: SMALL EXTRACELLULAR VESICLES OBTAINED FROM NEUROPILIN-1+ T REGULATORY CELLS AS A NOVEL TOOL FOR THE INDUCTION OF TRANSPLANTATION TOLERANCE

Pino-Lagos, K. (Principal Investigator) & Wyneken, Ú. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/21 → 31/03/25

Project: Research

FONDECYT REGULAR - 1211471: THE PATHOGENIC VICIOUS CYCLE BETWEEN PERIODONTITIS AND GESTATIONAL DIABETES MELLITUS: COMMUNICATION VIA BACTERIAL TRANSLOCATION AND EXTRACELLULAR VESICLES

Chaparro, A. (Principal Investigator), Busso, D. (Co-Investigator), Illanes, S. (Co-Investigator), Ramirez Lobos, V. (Co-Investigator), Hernández Ríos, E. (Co-Investigator) & Hoare, A. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/21 → 31/03/25

Project: Research

FONDECYT REGULAR - 1211749: IMPACT OF HORIZONTAL ARTIFICIAL TRANSFER OF MITOCHONDRIA ON UMBILICAL CORD BLOOD TRANSPLANTATION AND ITS CLINICAL RELEVANCE IN GRAFT VERSUS HOST DISEASE.

Khoury, M. (Principal Investigator), Luz Crawford, P. A. (Co-Investigator), Court, A. C. (Co-Investigator) & Figueroa, F. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/21 → 31/03/25

Project: Research

FONDECYT REGULAR - 1211353: INVESTIGATING THE IMMUNOREGULATORY AND ANTI-RHEUMATOID ARTHRITIS ACTIVITIES OF SMALL EXTRACELLULAR VESICLES-SHUTTLED BIOACTIVE MICRORNA DERIVED FROM GLYCOLYTIC MESENCHYMAL STEM CELL

Luz Crawford, P. A. (Principal Investigator), Khoury, M. (Co-Investigator), Alcayaga-Miranda, F. (Co-Investigator), Elizondo-Vega, R. (Co-Investigator), Altamirano, C. (Co-Investigator) & Nova-Lamperti, E. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/21 → 31/03/25

Project: Research

FONDECYT REGULAR - 1211376: INVESTIGATING THE EFFECT OF MAVS-ENRICHED MITOCHONDRIAL TRANSPLANTATION ON INTRACELLULAR ANTIVIRAL IMMUNITY AND THEIR RESTORATIVE AND IMMUNOMODULATORY EFFECTS IN A VIRAL-INDUCED ACUTE LUNG INJURY MODEL.

Cuenca, J. (Principal Investigator), Alcayaga-Miranda, F. (Co-Investigator), Khoury, M. (Co-Investigator), Hidalgo, Y. (Co-Investigator) & Kurte, M. (Principal Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/21 → 31/03/25

Project: Research

Franco-Chilean initiative for Intra-Mitochondrial microRNAs as new mediators of mesenchymal stem cells immunoregulatory functions

Luz Crawford, P. A. (Principal Investigator)

1/03/21 → 28/02/25

Project: Research

Millennium Institute on Immunology and Immunotherapy (IMII)

Kalergis, A. M. (Principal Investigator) & Luz Crawford, P. A. (Co-Investigator)

1/09/11 → 1/09/31

Project: Research

Not started

FONDECYT POSTDOCTORADO - 3240476: Characterization and validation of early biomarkers of maternal supraphysiological hypercholesterolemia in maternal plasma from the first trimester of pregnancy

Illanes, S. (Sponsoring Researcher) & Cantin, C. (Postdoctoral Researcher)

Agencia Nacional de Investigación y Desarrollo (ANID)

Project: Research

FONDECYT POSTDOCTORADO - 3240135: Parches cardiacos multifuncionales basados en biomateriales electroconductores cargados con células madre mesenquimales

Acevedo, J. P. (Sponsoring Researcher) & Olate, F. (Postdoctoral Researcher)

Agencia Nacional de Investigación y Desarrollo (ANID)

Project: Research

Finished

FAI INSCRIPCION CONGRESO - APO-CG-2023-28: INCREASED GINGIVAL CREVICULAR FLUID EXTRACELLULAR VESICLES ARE INVOLVED IN THE CROSSTALK BETWEEN PERIODONTITIS AND GESTATIONAL DIABETES

Mizgier, M. L. (Principal Investigator), Realini, O. (Co-Investigator), Bendek Viera, M. J. (Co-Investigator), Rojas Pérez, C. I. (Co-Investigator), Monje, S. (Co-Investigator), Figari, A. (Co-Investigator), Hernández, M. (Co-Investigator), Ramírez Lobos, V. (Co-Investigator), Illanes, S. (Co-Investigator), Busso, D. (Co-Investigator) & Chaparro, A. (Co-Investigator)

Universidad de los Andes Chile

4/09/23 → 30/12/23

Project: Research

Project Number 22I10126: Japi: Cognitive, Emotional and Social Stimulation for Preschool Children

Gaete Olivares, J. E. (Principal Investigator), Rojas-Barahona, C. A. (Co-Investigator), Matus Correa, P. I. (Co-Investigator) & Araya, R. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

17/10/22 → 17/10/24

Project: Research

CONTRATOS TECNOLOGICOS - 22CVID-206879: SCREENING ORAL PARA LA PREDICCIÓN TEMPRANA DE DIABETES GESTACIONAL

Chaparro, A. (Principal Investigator), Illanes, S. (Co-Investigator) & Nardocci, G. (Co-Investigator)

1/09/22 → 26/10/24

Project: Research

Glycostem-sev: generación de un producto acelular basado en nanovesículas extracelulares derivadas de células madre mesenquimales inducidas hacia un metabolismo glicolítico para el tratamiento de la osteoartritis

Luz Crawford, P. A. (Principal Investigator), Alcayaga-Miranda, F. (Co-Investigator), Elizondo-Vega, R. J. (Co-Investigator), Espinoza, F. (Co-Investigator) & Matas, J. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/11/21 → 30/11/23

Project: Research

Immunoregulatory and anti-rheumatoid arthritis activities of small extracellular vesicles-shuttled bioactive microRNA derived from glycolytic mesenchymal stem cells

Luz Crawford, P. A. (Principal Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/03/21 → 29/02/24

Project: Research

Metabolic reprograming of effector CD4+T cells by mitochondrial mediated-signalling in oral cancer and its effect upon T helper and T-dependent B cell responses

Nova, E. (Principal Investigator) & Luz Crawford, P. A. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/03/21 → 29/02/24

Project: Research

Generación de un extracto de un alimento andino con propiedades antidiabéticas

Busso, D. (Principal Investigator), Enrione, J. I. (Principal Investigator) & Illanes, S. (Principal Investigator)

1/08/20 → 30/11/20

Project: Research

Mirando al futuro: Efectos del estrés prenatal y perinatal asociado a la pandemia COVID-19 en el neurodesarrollo de niñas y niños de Chile

Batiz, L. F. (Director), Illanes, S. (Alternate Director), J. Monteiro, L. (Co-Investigator), Tenorio, M. (Co-Investigator), Avaria, M. D. L. A. (Co-Investigator), Nardocci, G. (Co-Investigator), Nuñez, M. I. (Co-Investigator) & Peñailillo, R. (Postdoctoral Researcher)

Agencia Nacional de Investigación y Desarrollo (ANID)

6/07/20 → 1/01/22

Project: Research

FONDECYT REGULAR - 1200693: Brain astrocyte-derived extracellular vesicles promote protective Treg induction in the GALT and restore gut tolerance in stressed rats

Wyneken, Ú. (Principal Investigator), Batiz, L. F. (Co-Principal Investigator), Pino-Lagos, K. (Co-Investigator) & Batiz, L. F. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/20 → 31/03/24

Project: Research

FONDECYT REGULAR - 1201420: Mitochondrial transfer within the osteoarthritic joint: restoration of the dysfunctional stress-response and metabolic pathway in cartilage in-vitro and in an animal model of disease

Figueroa, F. (Principal Investigator), Khoury, M. (Co-Investigator), Luz Crawford, P. A. (Co-Investigator) & Court, A. C. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/20 → 31/03/24

Project: Research

FONDECYT REGULAR - 1201851: Role of mesenchymal stem cells in implantation and their contribution to the decidualization disorders present in preeclampsia

Illanes, S. (Principal Investigator), Pino-Lagos, K. (Co-Investigator), J. Monteiro, L. (Co-Investigator) & Acuña, S. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/20 → 31/03/23

Project: Research

Lipophilic statins inhibit the exosome-mediated and obesity-induced cancer progression: the relevance of reestablishing natural killer cell immune surveillance to delay recurrence and improve future therapeutic outcomes in high-grade serous ovarian cancer

Cuello, M. (Principal Investigator) & Busso, D. (Co-Investigator)

1/03/20 → 28/02/23

Project: Research

Mitochondrial transfer from mesenchymal stem cells for osteoarthritis treatment

Figueroa, F. (Principal Investigator) & Luz Crawford, P. A. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/03/20 → 28/02/23

Project: Research

Validación de algoritmo multiparamétrico para la predicción temprana de Diabetes Gestacional mediante marcadores plasmáticos maternos

Illanes, S. (Director), J. Monteiro, L. (Alternate Director), Correa, P. (Co-Investigator) & Monckeberg, M. (Co-Investigator)

1/01/20 → 1/01/23

Project: Research

Estudio de Carga de Enfermedad Atribuible al Actual Nivel de Exposición a Yodo y Ácido Fólico en Chile: Identificación de Niveles Óptimos de Fortificación Nacional y Recomendaciones para una Nueva Política Integrada de Micronutrientes

Mosso, L. (Principal Investigator) & Busso, D. (Co-Investigator)

1/10/19 → 31/05/22

Project: Research

"ALERT-NeurodEV”: Early detection of prenatal stress-induced neurodevelopmental changes by umbilical cord blood biomarkers

Batiz, L. F. (Principal Investigator) & Illanes, S. (Co-Investigator)

Universidad de los Andes Chile

1/06/19 → 30/09/19

Project: Research

FONDECYT REGULAR - 1190411: Investigating the anti-angiogenic effect of exosome-mediated delivery of functionally active miRNA-149-3p,145-5p and 6131 to tumor tissue

Alcayaga-Miranda, F. (Principal Investigator), Cuenca, J. (Co-Investigator), Khoury, M. (Co-Investigator) & Pino-Lagos, K. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/19 → 15/04/23

Project: Research

Regulation of mesenchymal stem cell metabolic status to increase their immunosuppresive potential

Luz Crawford, P. A. (Principal Investigator)

1/04/19 → 31/03/21

Project: Research

FONDECYT POSTDOCTORADO - 3190646: ALFA-SNAP REGULA EL BALANCE ENTRE AUTORENOVACIÓN/PROLIFERACIÓN Y DIFERENCIACIÓN DE CÉLULAS MADRE NEURALES, MODULANDO LA ACTIVIDAD AMPK Y LA HOMEOSTASIS MITOCONDRIAL

Henzi, R. (Postdoctoral Researcher) & Batiz, L. F. (Sponsoring Researcher)

Consejo Nacional para Investigaciones Científicas y Tecnológicas

15/03/19 → 14/03/22

Project: Research

Use of protein biomarkers in plasma-derived extracellular vesicles to improve the diagnosis of bipolar disorder

Wyneken, Ú. (Principal Investigator), Batiz, L. F. (Co-Investigator) & Prieto, M. (Co-Principal Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/01/19 → 1/01/21

Project: Research

Regulation of mesenchymal stem cells metabolic status to improve their therapeutic potential for arthritis

Luz Crawford, P. A. (Principal Investigator)

1/01/19 → 31/12/20

Project: Research

FONDECYT INICIACIÓN - 11181249: THE ROLE OF FOXM1 IN EARLY PREECLAMPSIA-RELATED EVENTS

J. Monteiro, L. (Principal Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/11/18 → 16/05/23

Project: Research

FONDECYT REGULAR - 1181365: EFFECT OF GENETIC VARIANTS IN CALCIUM CHANNEL GENES ON CARDIAC FUNCTION IN BIPOLAR DISORDER

Batiz, L. F. (Co-Principal Investigator), Prieto, M. (Principal Investigator), De León, A. (Co-Investigator), Veas, N. (Co-Investigator), Cavada, G. (Co-Investigator) & Fullerton, C. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/18 → 31/03/23

Project: Research