Research output per year
Research output per year
Research output
- 1 - 50 out of 55 results
Search results
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2024
Bulk serum extracellular vesicles from stressed mice show a distinct proteome and induce behavioral and molecular changes in naive mice
Monteleone, M. C., Billi, S. C., Abarzúa-Catalán, L., Henzi, R., Fernández, E. M., Kaehne, T., Wyneken, U. & Brocco, M. A., 1 Aug 2024, In: PLoS ONE. 19, 8, e0308976.Research output: Contribution to journal › Article › peer-review
Open Access -
Editorial: Medicinal drugs, the effect on memories and beyond
Moreira-Rodrigues, M., Ampuero, E. & Wyneken, U., 2024, In: Frontiers in Pharmacology. 15, 1471049.Research output: Contribution to journal › Editorial
Open Access -
Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice
Acuña-Catalán, D., Shah, S., Wehrfritz, C., Nomura, M., Acevedo, A., Olmos, C., Quiroz, G., Huerta, H., Bons, J., Ampuero, E., Wyneken, U., Sanhueza, M., Arancibia, F., Contreras, D., Cárdenas, J. C., Morales, B., Schilling, B., Newman, J. C. & González-Billault, C., 18 Jun 2024, In: Cell Reports Medicine. 5, 6, 101593.Research output: Contribution to journal › Article › peer-review
Open Access -
Methadone directly impairs central nervous system cells in vitro
De Gregorio, C., Gallardo, J., Berríos-Cárcamo, P., Handy, Á., Santapau, D., González-Madrid, A., Ezquer, M., Morales, P., Luarte, A., Corvalán, D., Wyneken, Ú. & Ezquer, F., Dec 2024, In: Scientific Reports. 14, 1, 16978.Research output: Contribution to journal › Article › peer-review
Open Access -
The multifaceted effects of fluoxetine treatment on cognitive functions
Ampuero, E., Luarte, A., Flores, F. S., Soto, A. I., Pino, C., Silva, V., Erlandsen, M., Concha, T. & Wyneken, U., 2024, In: Frontiers in Pharmacology. 15, 1412420.Research output: Contribution to journal › Review article › peer-review
Open Access -
2023
Alpha-SNAP (M105I) mutation promotes neuronal differentiation of neural stem/progenitor cells through overactivation of AMPK
Bustamante-Barrientos, F. A., Méndez-Ruette, M., Molina, L., Koning, T., Ehrenfeld, P., González, C. B., Wyneken, U., Henzi, R. & Bátiz, L. F., 2023, In: Frontiers in Cell and Developmental Biology. 11, p. 1061777 1061777.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Astrocyte-derived extracellular vesicles in stress-associated mood disorders. Does the immune system get astrocytic?
Luarte, A., Nardocci, G., Chakraborty, A., Batiz, L. F., Pino-Lagos, K. & Wyneken, Ú., Aug 2023, In: Pharmacological Research. 194, 106833.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Cannabinoid regulation of neurons in the dentate gyrus during epileptogenesis: Role of CB1R-associated proteins and downstream pathways
Lafourcade, C. A., Sparks, F. T., Bordey, A., Wyneken, U. & Mohammadi, M. H., 2023, In: Epilepsia. 64, 6, p. 1432-1443 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Behavioral and Molecular Responses to Exogenous Cannabinoids During Pentylenetetrazol-Induced Convulsions in Male and Female Rats
Zirotti Rosenberg, A., Méndez-Ruette, M., Gorziglia, M., Alzerreca, B., Cabello, J., Kaufmann, S., Rambousek, L., Iturriaga Jofré, A., Wyneken, U. & Lafourcade, C. A., 9 Aug 2022, In: Frontiers in Molecular Neuroscience. 15, p. 868583 868583.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
MÉTODO DE DIAGNÓSTICO DE TRASTORNO BIPOLAR BASADO EN BIOMARCADORES PRESENTES EN MUESTRAS DE SANGRE PERIFÉRICA
Prieto, M. (Inventor), Wyneken, Ú. (Inventor) & Godoy, M. I. (Inventor), 2022Research output: Patent
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Neuronal activity-dependent ATP enhances the pro-growth effect of repair Schwann cell extracellular vesicles by increasing their miRNA-21 loading
Saquel, C., Catalan, R. J., Lopez-Leal, R., Ramirez, R. A., Necuñir, D., Wyneken, U., Lamaze, C. & Court, F. A., 23 Sep 2022, In: Frontiers in Cellular Neuroscience. 16, p. 943506 943506.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Neuropilin-1 is present on Foxp3+ T regulatory cell-derived small extracellular vesicles and mediates immunity against skin transplantation
Campos-Mora, M., De Solminihac, J., Rojas, C., Padilla, C., Kurte, M., Pacheco, R., Kaehne, T., Wyneken, Ú. & Pino-Lagos, K., Jun 2022, In: Journal of Extracellular Vesicles. 11, 6, e12237.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
2021
eNOS-dependent S-nitrosylation of the NF-κB subunit p65 has neuroprotective effects
Caviedes, A., Maturana, B., Corvalán, K., Engler, A., Gordillo, F., Varas-Godoy, M., Smalla, K. H., Batiz, L. F., Lafourcade, C., Kaehne, T. & Wyneken, Ú., 4 Jan 2021, In: Cell Death and Disease. 12, 1, p. 4 4.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Maternal exposure to a high-magnitude earthquake during pregnancy influences pre-reading skills in early childhood
Bátiz, L. F., Palmeiro-Silva, Y. K., Rice, G. E., Monteiro, L. J., Galaburda, A. M., Romero, R., Choolani, M. A., Wyneken, U., Orellana, P. & Illanes, S. E., Dec 2021, In: Scientific Reports. 11, 1, p. 9244 9244.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Prenatal fluoxetine impairs non-hippocampal but not hippocampal memory in adult male rat offspring
Moraga-Amaro, R., Díaz-Galarce, R., Donoso-Ramos, J. P., Ugalde, V., Linsambarth, S., Doorduin, J., de Vries, E. F., Ampuero, E., Peña, F., Pacheco, R., Wyneken, U. & Stehberg, J., 1 Oct 2021, In: Neuropharmacology. 197, p. 108751 108751.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2020
A Role for mir-26a in Stress: A Potential sEV Biomarker and Modulator of Excitatory Neurotransmission
Lafourcade, C. A., Fernández, A., Ramírez, J. P., Corvalán, K., Carrasco, M. Á., Iturriaga, A., Bátiz, L. F., Luarte, A. & Wyneken, U., 1 Jun 2020, In: Cells. 9, 6, 1365.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Astrocyte-Derived Small Extracellular Vesicles Regulate Dendritic Complexity through miR-26a-5p Activity
Luarte, A., Henzi, R., Fernández, A., Gaete, D., Cisternas, P., Pizarro, M., Batiz, L. F., Villalobos, I., Masalleras, M., Vergara, R., Varas-Godoy, M., Abarzua-Catalan, L., Herrera-Molina, R., Lafourcade, C. & Wyneken, U., 10 Apr 2020, In: Cells. 9, 4, 945.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
miRNAs of Astrocyte-Derived Small Extracellular Vesicles Potentially Modulate Adult Neurogenesis Under Stress Conditions
Bustamante, F., Méndez-Ruette, M., Wyneken, U., Bátiz, L. F. & Henzi, R., 1 Jan 2020, Stress: Genetics, Epigenetics and Genomics. Fink, G. (ed.). Academic Press Inc., Vol. 4. p. 179-193 15 p. (Stress: Genetics, Epigenetics and Genomics).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Open Access -
Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG
Espinoza, S., Arredondo, S. B., Barake, F., Carvajal, F., Guerrero, F. G., Segovia-Miranda, F., Valenzuela, D. M., Wyneken, Ú., Rojas-Fernández, A., Cerpa, W., Massardo, L., Varela-Nallar, L. & González, A., 1 Dec 2020, In: BMC Biology. 18, 1, 164.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Semipermeable Cellulose Beads Allow Selective and Continuous Release of Small Extracellular Vesicles (sEV) From Encapsulated Cells
Zavala, G., Ramos, M. P., Figueroa-Valdés, A. I., Cisternas, P., Wyneken, U., Hernández, M., Toa, P., Salmons, B., Dangerfield, J., Gunzburg, W. H. & Khoury, M., 21 May 2020, In: Frontiers in Pharmacology. 11, 679.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2019
Chronic fluoxetine treatment induces maturation-compatible changes in the dendritic arbor and in synaptic responses in the auditory cortex
Ampuero, E., Cerda, M., Härtel, S., Rubio, F. J., Massa, S., Cubillos, P., Abarzúa-Catalán, L., Sandoval, R., Galaburda, A. M. & Wyneken, U., 2019, In: Frontiers in Pharmacology. 10, 804.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2018
Small Extracellular Vesicles in Rat Serum Contain Astrocyte-Derived Protein Biomarkers of Repetitive Stress
Gómez-Molina, C., Sandoval, M., Henzi, R., Ramírez, J. P., Varas-Godoy, M., Luarte, A., Lafourcade, C. A., Lopez-Verrilli, A., Smalla, K. H., Kaehne, T. & Wyneken, U., 8 Dec 2018, In: International Journal of Neuropsychopharmacology. 22, 3, p. 232-246 15 p.Research output: Contribution to journal › Article › peer-review
Open Access53 Scopus citations -
2017
Astrocytes at the hub of the stress response: potential modulation of neurogenesis by miRNAs in astrocyte-derived exosomes
Luarte, A., Cisternas, P., Caviedes, A., Batiz, L. F., Lafourcade, C., Wyneken, U. & Henzi, R., 2017, In: Stem Cells International. 2017, 1719050.Research output: Contribution to journal › Review article › peer-review
Open Access74 Scopus citations -
BDNF/NF-κB signaling in the neurobiology of depression
Caviedes, A., Lafourcade, C., Soto, C. & Wyneken, U., 1 Jan 2017, In: Current Pharmaceutical Design. 23, 21, p. 3154-3163 10 p.Research output: Contribution to journal › Scientific review › peer-review
168 Scopus citations -
Endothelial nitric oxide synthase is present in dendritic spines of neurons in primary cultures
Caviedes, A., Varas-Godoy, M., Lafourcade, C., Sandoval, S., Bravo-Alegria, J., Kaehne, T., Massmann, A., Figueroa, J. P., Nualart, F. & Wyneken, U., 4 Jul 2017, In: Frontiers in Cellular Neuroscience. 11, 180.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice
Bustos, F. J., Ampuero, E., Jury, N., Aguilar, R., Falahi, F., Toledo, J., Ahumada, J., Lata, J., Cubillos, P., Henríquez, B., Guerra, M. V., Stehberg, J., Neve, R. L., Inestrosa, N. C., Wyneken, U., Fuenzalida, M., Härtel, S., Sena-Esteves, M., Varela-Nallar, L. & Rots, M. G. & 2 others, , 1 Dec 2017, In: Brain. 140, 12, p. 3252-3268 17 p.Research output: Contribution to journal › Article › peer-review
Open Access129 Scopus citations -
In vivo sub-chronic treatment with dichlorvos in young rats promotes synaptic plasticity and learning by a mechanism that involves Acylpeptide Hydrolase instead of acetylcholinesterase inhibition. Correlation with endogenous β-amyloid levels
García-Rojo, G., Gámiz, F., Ampuero, E., Rojas-Espina, D., Sandoval, R., Rozas, C., Morales, B., Wyneken, U. & Pancetti, F., 25 Jul 2017, In: Frontiers in Pharmacology. 8, JUL, 483.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2016
Exosomes as novel regulators of adult neurogenic niches
Batiz, L. F., Castro, M. A., Burgos, P. V., Velásquez, Z. D., Muñoz, R. I., Lafourcade, C., Troncoso-Escudero, P. & Wyneken, Ú., 19 Jan 2016, In: Frontiers in Cellular Neuroscience. 9, JAN2016, 501.Research output: Contribution to journal › Article › peer-review
Open Access118 Scopus citations -
Mesenchymal stem cell-derived exosomes from different sources selectively promote neuritic outgrowth
Lopez-Verrilli, M. A., Caviedes, A., Cabrera, A., Sandoval, S., Wyneken, U. & Khoury, M., 21 Apr 2016, In: Neuroscience. 320, p. 129-139 11 p.Research output: Contribution to journal › Article › peer-review
171 Scopus citations -
MiRNAs in astrocyte-derived exosomes as possible mediators of neuronal plasticity
Lafourcade, C., Ramírez, J. P., Luarte, A., Fernández, A. & Wyneken, U., 2016, In: Journal of Experimental Neuroscience. 2016, p. 1-9 9 p.Research output: Contribution to journal › Comment/debate
Open Access78 Scopus citations -
Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta
Palacios, J., Cifuentes, F., Valderrama, J. A., Benites, J., Ríos, D., González, C., Chiong, M., Cartes-Saavedra, B., Lafourcade, C., Wyneken, U., González, P., Owen, G. I., Pardo, F., Sobrevia, L. & Buc Calderon, P., 2016, In: Oxidative Medicine and Cellular Longevity. 2016, 3939540.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche
Luarte, A., Bátiz, L. F., Wyneken, U. & Lafourcade, C., 2016, In: Stem Cells International. 2016, 5736059.Research output: Contribution to journal › Review article › peer-review
Open Access77 Scopus citations -
2015
Two chronic stress models based on movement restriction in rats respond selectively to antidepressant drugs: Aldolase C as a potential biomarker
Ampuero, E., Luarte, A., Santibañez, M., Varas-Godoy, M., Toledo, J., Diaz-Veliz, G., Cavada, G., Javier Rubio, F. & Wyneken, U., Sep 2015, In: International Journal of Neuropsychopharmacology. 18, 10Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
2014
Electroencephalographic characterization of pentylenetetrazole kindling in rats and modulation of epileptiform discharges by nitric oxide
Bartsch, V., Díaz, J., González, I., Cavada, G., Ocampo-Garcés, A. & Wyneken, U., Feb 2014, In: Neurochemical Research. 39, 2, p. 408-418 11 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
2013
Isolation of the postsynaptic density: a specialization of the subsynaptic cytoskeleton.
Smalla, K. H., Klemmer, P. & Wyneken, U., 2013, The Cytoskeleton: Imaging, Isolation, and Interaction. Humana Press Inc., p. 265-280 16 p. (Neuromethods; vol. 79).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
11 Scopus citations -
Long-term fluoxetine treatment induces input-specific LTP and LTD impairment and structural plasticity in the CA1 hippocampal subfield
Rubio, F. J., Ampuero, E., Sandoval, R., Toledo, J., Pancetti, F. & Wyneken, U., 20 Apr 2013, In: Frontiers in Cellular Neuroscience. APRResearch output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
Repetitive fluoxetine treatment affects long-term memories but not learning
Ampuero, E., Stehberg, J., Gonzalez, D., Besser, N., Ferrero, M., Diaz-Veliz, G., Wyneken, U. & Rubio, F. J., 5 Jun 2013, In: Behavioural Brain Research. 247, p. 92-100 9 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
The glycolytic enzyme aldolase C is up-regulated in rat forebrain microsomes and in the cerebrospinal fluid after repetitive fluoxetine treatment
Sandoval, M., Luarte, A., Herrera-Molina, R., Varas-Godoy, M., Santibáñez, M., Rubio, F. J., Smit, A. B., Gundelfinger, E. D., Li, K. W., Smalla, K. H. & Wyneken, U., 3 Jul 2013, In: Brain Research. 1520, p. 1-14 14 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
2012
Synaptic localization of acylpeptide hydrolase in adult rat telencephalon
Sandoval, R., Navarro, S., García-Rojo, G., Calderón, R., Pedrero, A., Sandoval, S., Wyneken, U. & Pancetti, F., 27 Jun 2012, In: Neuroscience Letters. 520, 1, p. 98-103 6 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
2010
Chronic fluoxetine treatment induces structural plasticity and selective changes in glutamate receptor subunits in the rat cerebral cortex
Ampuero, E., Rubio, F. J., Falcon, R., Sandoval, M., Diaz-Veliz, G., Gonzalez, R. E., Earle, N., Dagnino-Subiabre, A., Aboitiz, F., Orrego, F. & Wyneken, U., Aug 2010, In: Neuroscience. 169, 1, p. 98-108 11 p.Research output: Contribution to journal › Article › peer-review
117 Scopus citations -
Intranigral Transplantation of Epigenetically Induced BDNF-Secreting Human Mesenchymal Stem Cells: Implications for Cell-Based Therapies in Parkinson's Disease
Somoza, R., Juri, C., Baes, M., Wyneken, U. & Rubio, F. J., Nov 2010, In: Biology of Blood and Marrow Transplantation. 16, 11, p. 1530-1540 11 p.Research output: Contribution to journal › Article › peer-review
Open Access60 Scopus citations -
2009
Chronic stress induces dendritic atrophy in the rat medial geniculate nucleus: Effects on auditory conditioning
Dagnino-Subiabre, A., Muñoz-Llancao, P., Terreros, G., Wyneken, U., Díaz-Véliz, G., Porter, B., Kilgard, M. P., Atzori, M. & Aboitiz, F., 12 Oct 2009, In: Behavioural Brain Research. 203, 1, p. 88-96 9 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Effect of short-term exposure to dichlorvos on synaptic plasticity of rat hippocampal slices: Involvement of acylpeptide hydrolase and α7 nicotinic receptors
Olmos, C., Sandoval, R., Rozas, C., Navarro, S., Wyneken, U., Zeise, M., Morales, B. & Pancetti, F., 1 Jul 2009, In: Toxicology and Applied Pharmacology. 238, 1, p. 37-46 10 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
2008
Scaffolding proteins in highly purified rat olfactory cilia membranes
Saavedra, M. V., Smalla, K. H., Thomas, U., Sandoval, S., Olavarria, K., Castillo, K., Delgado, M. G., Delgado, R., Gundelfinger, E. D., Bacigalupo, J. & Wyneken, U., 16 Jul 2008, In: NeuroReport. 19, 11, p. 1123-1126 4 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
2007
Antagonistic effects of TrkB and p75NTR on NMDA receptor currents in post-synaptic densities transplanted into Xenopus oocytes
Sandoval, M., Sandoval, R., Thomas, U., Spilker, C., Smalla, K. H., Falcon, R., Marengo, J. J., Calderón, R., Saavedra, V., Heumann, R., Bronfman, F., Garner, C. C., Gundelfinger, E. D. & Wyneken, U., 1 Jun 2007, In: Journal of Neurochemistry. 101, 6, p. 1672-1684 13 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Status epilepticus induces region-specific changes in dendritic spines, dendritic length and TrkB protein content of rat brain cortex
Ampuero, E., Dagnino-Subiabre, A., Sandoval, R., Zepeda-Carreño, R., Sandoval, S., Viedma, A., Aboitiz, F., Orrego, F. & Wyneken, U., 31 Aug 2007, In: Brain Research. 1150, 1, p. 225-238 14 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
2006
Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats
Dagnino-Subiabre, A., Orellana, J. A., Carmona-Fontaine, C., Montiel, J., Díaz-Velíz, G., Serón-Ferré, M., Wyneken, U., Concha, M. L. & Aboitiz, F., 1 Jun 2006, In: Journal of Neurochemistry. 97, 5, p. 1279-1287 9 p.Research output: Contribution to journal › Article › peer-review
44 Scopus citations -
Clinically relevant doses of fluoxetine and reboxetine induce changes in the TrkB content of central excitatory synapses
Wyneken, U., Sandoval, M., Sandoval, S., Jorquera, F., González, I., Vargas, F., Falcon, R., Monari, M. & Orrego, F., 7 Nov 2006, In: Neuropsychopharmacology. 31, 11, p. 2415-2423 9 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
2004
Electrophysiology and plasticity in isolated postsynaptic densities
Wyneken, U., Marengo, J. J. & Orrego, F., Dec 2004, In: Brain Research Reviews. 47, 1-3, p. 54-70 17 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
2003
Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities
Wyneken, U., Marengo, J. J., Villanueva, S., Soto, D., Sandoval, R., Gundelfinger, E. D. & Orrego, F., 1 Feb 2003, In: Epilepsia. 44, 2, p. 243-246 4 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations