Grupo de Investigación Traslacional en Autoinmunidad

2020

Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response

Court, A. C., Le-Gatt, A., Luz-Crawford, P., Parra, E., Aliaga-Tobar, V., Bátiz, L. F., Contreras, R. A., Ortúzar, M. I., Kurte, M., Elizondo-Vega, R., Maracaja-Coutinho, V., Pino-Lagos, K., Figueroa, F. E. & Khoury, M., 5 Feb 2020, In: EMBO Reports. 21, 2, e48052.

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

2019

Adipose tissue-derived mesenchymal stromal cells in patients with chronic kidney disease: A pilot study assessing safety and clinical feasibility

Villanueva, S., González, F., Lorca, E., Tapia, A., Valentina López, G., Strodthoff, R., Fajre, F., Carreño, J. E., Valjalo, R., Vergara, C., Lecanda, M., Bartolucci, J., Figueroa, F. E. & Khoury, M., 2019, In: Kidney Research and Clinical Practice. 38, 2, p. 176-185 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial

Matas, J., Orrego, M., Amenabar, D., Infante, C., Tapia-Limonchi, R., Cadiz, M. I., Alcayaga-Miranda, F., González, P. L., Muse, E., Khoury, M., Figueroa, F. E. & Espinoza, F., Mar 2019, In: Stem cells translational medicine. 8, 3, p. 215-224 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

160 Scopus citations

2018

IL17/IL17RA as a novel signaling axis driving mesenchymal stem cell therapeutic function in experimental autoimmune encephalomyelitis

Kurte, M., Luz-Crawford, P., Vega-Letter, A. M., Contreras, R. A., Tejedor, G., Elizondo-Vega, R., Martinez-Viola, L., Fernández-O'Ryan, C., Figueroa, F. E., Jorgensen, C., Djouad, F. & Carrión, F., 30 Apr 2018, In: Frontiers in Immunology. 9, APR, 802.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

2017

Safety and efficacy of the intravenous infusion of umbilical cord mesenchymal stem cells in patients with heart failure: A phase 1/2 randomized controlled trial (RIMECARD trial [Randomized clinical trial of intravenous infusion umbilical cord mesenchymal stem cells on cardiopathy])

Bartolucci, J., Verdugo, F. J., González, P. L., Larrea, R. E., Abarzua, E., Goset, C., Rojo, P., Palma, I., Lamich, R., Pedreros, P. A., Valdivia, G., Lopez, V. M., Nazzal, C., Alcayaga-Miranda, F., Cuenca, J., Brobeck, M. J., Patel, A. N., Figueroa, F. E. & Khoury, M., 2017, In: Circulation Research. 121, 10, p. 1192-1204 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

249 Scopus citations

2016

Differential TLR activation of murine mesenchymal stem cells generates distinct immunomodulatory effects in EAE

Vega-Letter, A. M., Kurte, M., Fernández-O'Ryan, C., Gauthier-Abeliuk, M., Fuenzalida, P., Moya-Uribe, I., Altamirano, C., Figueroa, F., Irarrázabal, C. & Carrión, F., 10 Oct 2016, In: Stem Cell Research and Therapy. 7, 1, p. 1-12 12 p., 150.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Overexpression of glutamate decarboxylase in mesenchymal stem cells enhances their immunosuppressive properties and increases GABA and nitric oxide levels

Urrutia, M., Fernández, S., González, M., Vilches, R., Rojas, P., Vásquez, M., Kurte, M., Vega-Letter, A. M., Carrión, F., Figueroa, F., Rojas, P., Irarrázabal, C. & Fuentealba, R. A., Sep 2016, In: PLoS ONE. 11, 9, e0163735.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

The immunosuppressive signature of menstrual blood mesenchymal stem cells entails opposite effects on experimental arthritis and graft versus host diseases

Luz-Crawford, P., Torres, M. J., Noël, D., Fernandez, A., Toupet, K., Alcayaga-Miranda, F., Tejedor, G., Jorgensen, C., Illanes, S. E., Figueroa, F. E., Djouad, F. & Khoury, M., 1 Feb 2016, In: Stem Cells. 34, 2, p. 456-469 14 p.

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Toll-like receptor 3 pre-conditioning increases the therapeutic efficacy of umbilical cord mesenchymal stromal cells in a dextran sulfate sodium-induced colitis model

Fuenzalida, P., Kurte, M., Fernández-O'ryan, C., Ibañez, C., Gauthier-Abeliuk, M., Vega-Letter, A. M., Gonzalez, P., Irarrázabal, C., Quezada, N., Figueroa, F. & Carrión, F., 1 May 2016, In: Cytotherapy. 18, 5, p. 630-641 12 p.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

2015

Characterization of menstrual stem cells: Angiogenic effect, migration and hematopoietic stem cell support in comparison with bone marrow mesenchymal stem cells

Alcayaga-Miranda, F., Cuenca, J., Luz-Crawford, P., Aguila-Díaz, C., Fernandez, A., Figueroa, F. E. & Khoury, M., 17 Mar 2015, In: Stem Cell Research and Therapy. 6, 1, 32.

Research output: Contribution to journal › Article › peer-review

Open Access

107 Scopus citations

Chorion mesenchymal stem cells show superior differentiation, immunosuppressive, and angiogenic potentials in comparison with haploidentical maternal placental cells

González, P. L., Carvajal, C., Cuenca, J., Alcayaga-Miranda, F., Figueroa, F. E., Bartolucci, J., Salazar-Aravena, L. & Khoury, M., 1 Oct 2015, In: Stem cells translational medicine. 4, 10, p. 1109-1121 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

Combination therapy of menstrual derived mesenchymal stem cells and antibiotics ameliorates survival in sepsis

Alcayaga-Miranda, F., Cuenca, J., Martin, A., Contreras, L., Figueroa, F. E. & Khoury, M., 16 Oct 2015, In: Stem Cell Research and Therapy. 6, 1, 199.

Research output: Contribution to journal › Article › peer-review

Open Access

97 Scopus citations

Intravenous administration of bone marrow-derived mesenchymal stem cells induces a switch from classical to atypical symptoms in experimental autoimmune encephalomyelitis

Kurte, M., Bravo-Alegría, J., Torres, A., Carrasco, V., Ibáñez, C., Vega-Letter, A. M., Fernández-O'Ryan, C., Irarrázabal, C. E., Figueroa, F. E., Fuentealba, R. A., Riedel, C. & Carrión, F., 2015, In: Stem Cells International. 2015, 140170.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Microrna profiling of b cell subsets from systemic lupus erythematosus patients reveals promising novel biomarkers

Duroux-Richard, I., Cuenca, J., Ponsolles, C., Piñeiro, A. B., Gonzalez, F., Roubert, C., Areny, R., Chea, R., Pefaur, J., Pers, Y. M., Figueroa, F. E., Jorgensen, C., Khoury, M. & Apparailly, F., 2015, In: International Journal of Molecular Sciences. 16, 8, p. 16953-16965 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Resultados a largo plazo del trasplante intracoronario de células mononucleares de médula ósea autólogas en pacientes con cardiopatía dilatada de diversa etiología

Translated title of the contribution: Long-term results of intracoronary transplantation of autologous bone marrow cells in dilated cardiomyopathyBartolucci, J., Verdugo, F. J., Carrion, F., Abarzúa, E., Goset, C., Lamich, R., Sanhueza, P., Pedreros, P., Nazzal, C., Khoury, M. & Figueroa, F. E., 2015, In: Revista Medica de Chile. 143, 4, p. 415-423 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2014

Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes

Amador, C. A., Barrientos, V., Peña, J., Herrada, A. A., González, M., Valdés, S., Carrasco, L., Alzamora, R., Figueroa, F., Kalergis, A. M. & Michea, L., Apr 2014, In: Hypertension. 63, 4, p. 797-803 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

152 Scopus citations

2013

Human mesenchymal stem cells derived from adipose tissue reduce functional and tissue damage in a rat model of chronic renal failure

Villanueva, S., Carreño, J. E., Salazar, L., Vergara, C., Strodthoff, R., Fajre, F., Céspedes, C., Sáez, P. J., Irarrázabal, C., Bartolucci, J., Figueroa, F. & Vio, C. P., Aug 2013, In: Clinical Science. 125, 4, p. 199-210 12 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Increased inflammatory biomarkers in early pregnancy is associated with the development of pre-eclampsia in patients with periodontitis: A case control study

Chaparro, A., Sanz, A., Quintero, A., Inostroza, C., Ramirez, V., Carrion, F., Figueroa, F., Serra, R. & Illanes, S. E., Jun 2013, In: Journal of Periodontal Research. 48, 3, p. 302-307 6 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Mesenchymal stem cells generate a CD4⁺CD25⁺Foxp3 ⁺ regulatory T cell population during the differentiation process of Th1 and Th17 cells

Luz-Crawford, P., Kurte, M., Bravo-Alegría, J., Contreras, R., Nova-Lamperti, E., Tejedor, G., Noël, D., Jorgensen, C., Figueroa, F., Djouad, F. & Carrión, F., 2013, In: Stem Cell Research and Therapy. 4, 3, 65.

Research output: Contribution to journal › Article › peer-review

Open Access

328 Scopus citations

2012

IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction

Ávalos, A. M., Apablaza, F. A., Quiroz, M., Toledo, V., Peña, J. P., Michea, L., Irarrázabal, C. E., Carrión, F. A. & Figueroa, F. E., 2012, In: Biological Research. 45, 2, p. 193-200 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Mesenchymal Stem Cells Repress Th17 Molecular Program through the PD-1 Pathway

Luz-Crawford, P., Noël, D., Fernandez, X., Khoury, M., Figueroa, F., Carrión, F., Jorgensen, C. & Djouad, F., 17 Sep 2012, In: PLoS ONE. 7, 9, e45272.

Research output: Contribution to journal › Article › peer-review

Open Access

71 Scopus citations

Mesenchymal Stem Cell treatment for autoimmune diseases: A critical review

Figueroa, F. E., Carrión, F., Villanueva, S. & Khoury, M., 2012, In: Biological Research. 45, 3, p. 269-277 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

132 Scopus citations

2011

Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model

Villanueva, S., Ewertz, E., Carrión, F., Tapia, A., Vergara, C., Céspedes, C., Sáez, P. J., Luz, P., Irarrázabal, C., Carreño, J. E., Figueroa, F. & Vio, C. P., Dec 2011, In: Clinical Science. 121, 11, p. 489-499 11 p.

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4 ⁺ T cell activation.

Carrión, F., Nova, E., Luz, P., Apablaza, F. & Figueroa, F., 30 Mar 2011, In: Immunology Letters. 135, 1-2, p. 10-16 7 p.

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

2010

Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity

Herrada, A. A., Contreras, F. J., Marini, N. P., Amador, C. A., González, P. A., Cortés, C. M., Riedel, C. A., Carvajal, C. A., Figueroa, F., Michea, L. F., Fardella, C. E. & Kalergis, A. M., 1 Jan 2010, In: Journal of Immunology. 184, 1, p. 191-202 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

126 Scopus citations

Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients

Carrion, F., Nova, E., Ruiz, C., Diaz, F., Inostroza, C., Rojo, D., MÖnckeberg, G. & Figueroa, F. E., Mar 2010, In: Lupus. 19, 3, p. 317-322 6 p.

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

2009

Infections in patients with systemic lupus erythematosus

Enberg G., M., Kahn C., M., Goity F., C., Villalón S., M. V., Zamorano R., J. & Figueroa E., F., 1 Oct 2009, In: Revista Medica de Chile. 137, 10, p. 1367-1374 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2007

Patient self-administered joint tenderness counts in rheumatoid arthritis are reliable and responsive to changes in disease activity

Figueroa, F., Braun-Moscovici, Y., Khanna, D., Voon, E., Gallardo, L., Luinstra, D., Pina, X., Henstorf, G., Laurence, S., Neiman, R. & Furst, D., 1 Jan 2007, In: Journal of Rheumatology. 34, 1, p. 54-56 3 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Presence of bacterial DNA in valvular tissue of patients with rheumatic heart disease

Figueroa, F. E., Carrión A, F., Valenzuela M, S., Turner G, E., Aceitón E, C., Hirigoyen P, C., Bogdanic W, K., Solís D, C., Mansilla A, K. & Urra G, S., 1 Aug 2007, In: Revista Medica de Chile. 135, 8, p. 959-966 8 p.

Research output: Contribution to journal › Article › peer-review

2003

Polymorphisms of Fcγlla receptors in Chilean patients with systemic lupus erythematosus

Carrión A, F., Figueroa E, F., Martínez R, M. E., Massardo V, L., Pérez G, T., Foster B, C., Mancilla M, C., Neira Q, O., Guzmán B, L., Valenzuela M, V., Urrutia L, R., Carmona G, S., Figueroa, M., Lubiano A, A. & Wainstein G, E., 1 Jan 2003, In: Revista Medica de Chile. 131, 1, p. 11-18 8 p.

Research output: Contribution to journal › Article › peer-review

Selective depletion of Vβ2+CD8+ T cells in peripheral blood from rheumatic heart disease patients

Carrión, F., Fernandez, M., Iruretagoyena, M., Coelho Andrade, L. E., Odete-Hilário, M. & Figueroa, F., Mar 2003, In: Journal of Autoimmunity. 20, 2, p. 183-190 8 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2002

Eosinophilic fasciitis: Report of three cases

Velásquez G, X., Gutiérrez T, M. A., Rosenberg G, H., Figueroa E, F., Bronstein A, E. & Jacobelli G., S., 1 Feb 2002, In: Revista Medica de Chile. 130, 2, p. 209-214 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Restriction in the usage of variable β regions in T-cells infiltrating valvular tissue from rheumatic heart disease patients

Figueroa, F., González, M., Carrión, F., Lobos, C., Turner, F., Lasagna, N. & Valdés, F., Dec 2002, In: Journal of Autoimmunity. 19, 4, p. 233-240 8 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2001

Prospective comparison of clinical and echocardiographic diagnosis of rheumatic carditis: Long term follow up of patients with subclinical disease

Figueroa, F. E., Valdés, P., Carrión, F., Valdés, F., Soledad Fernández, M., Wilson, C., Berríos, X. & Lanas, F., 2001, In: Heart. 85, 4, p. 407-410 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

91 Scopus citations

2000

La inmunología clínica actual: una perspectiva genética y molecular

Carrión A, F., Figueroa, F. E. & Rodríguez G, C., 1 Jun 2000, In: Revista Medica de Chile. 128, 6, p. 650-658 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

1998

Efectos de la bromocriptina en pacientes con artritis reumatoide activa

Translated title of the contribution: Effects of bromocriptine in patients with active rheumatoid arthritisFigueroa E, F., Carrión A, F., Martínez R, M. E., Rivero D, S., Mamani V, I. & González V, G., Jan 1998, In: Revista Medica de Chile. 126, 1, p. 33-41 9 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

1996

Association of primary antiphospholipid syndrome with primary adrenal insufficiency

González, G., Gutiérrez, M., Ortiz, M., Tellez, R., Figueroa, F. & Jacobelli, S., 1 Aug 1996, In: Journal of Rheumatology. 23, 7, p. 1286-1287 2 p.

Research output: Contribution to journal › Article › peer-review

1993

Modificación farmacológica de la prolactinemia: Effectos sobre la función inmune celular en individuos normales

Translated title of the contribution: Pharmacological modification of prolactinemia. Effects on cellular immune function in normal subjectsFigueroa, F., Carrión, F., González, G., Rivero, S., Arteaga, E. & Mamani, I., Sep 1993, In: Revista Medica de Chile. 121, 9, p. 975-981 7 p.

Research output: Contribution to journal › Article › peer-review

1992

Anticardiolipin antibodies in acute rheumatic fever

Figueroa, F., Berrios, X., Gutierrez, M., Carrion, F., Pablo Goycolea, J., Riedel, I. & Jacobelli, S., 1992, In: Journal of Rheumatology. 19, 8, p. 1175-1180 6 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

1991

Infections in systemic lupus erythematosus

Massardo, L., Martínez, M. E., Baro, M., Figueroa, F., Rivero, S. & Jacobelli, S., 1 Jan 1991, In: Revista médica de Chile. 119, 10, p. 1115-1122 8 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

1989

Enfermedad del tejido conectivo materna asociada a bloqueo av congenito

Translated title of the contribution: Maternal connective tissue disease associated with congenital AV blockGutiérrez, M., Figueroa, F., Rivero, S., Salles, J. P., Arnaiz, P., Cruzat, L. & Jacobelli, S., Jul 1989, In: Revista Medica de Chile. 117, 7, p. 789-793 5 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Grupo de Investigación Traslacional en Autoinmunidad

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