Grupo de Fisiología Integrativa

2024

Levels of Small Extracellular Vesicles Containing hERG-1 and Hsp47 as Potential Biomarkers for Cardiovascular Diseases

Osorio, L. A., Lozano, M., Soto, P., Moreno-Hidalgo, V., Arévalo-Gil, A., Ramírez-Balaguera, A., Hevia, D., Cifuentes, J., Hidalgo, Y., Alcayaga-Miranda, F., Pasten, C., Morales, D., Varela, D., Urquidi, C., Iturriaga, A., Rivera-Palma, A., Larrea-Gómez, R. & Irarrázabal, C. E., May 2024, In: International Journal of Molecular Sciences. 25, 9, 4913.

Research output: Contribution to journal › Article › peer-review

Open Access

The protective effect of 1400W against ischaemia and reperfusion injury is countered by transient medullary kidney endothelial dysregulation

Pasten, C., Lozano, M., Osorio, L. A., Cisterna, M., Jara, V., Sepúlveda, C., Ramírez-Balaguera, D., Moreno-Hidalgo, V., Arévalo-Gil, D., Soto, P., Hurtado, V., Morales, A., Méndez, G. P., Busso, D., Leon, P., Michea, L., Corvalán, D., Luarte, A. & Irarrazabal, C. E., 2024, (Accepted/In press) In: Journal of Physiology.

Research output: Contribution to journal › Article › peer-review

2023

Clinical Characteristics and Outcomes of Drug-Induced Acute Kidney Injury Cases

Yousif, Z. K., Koola, J. D., Macedo, E., Cerda, J., Goldstein, S. L., Chakravarthi, R., Lewington, A., Selewski, D., Zappitelli, M., Cruz, D., Tolwani, A., Joy, M. S., Jha, V., Ramachandran, R., Ostermann, M., Pandya, B., Acharya, A., Brophy, P., Ponce, D. & Steinke, J. & 23 others, Bouchard, J., Irarrazabal, C. E., Irarrazabal, R., Boltansky, A., Askenazi, D., Kolhe, N., Claure-Del Granado, R., Benador, N., Castledine, C., Davenport, A., Barratt, J., Bhandari, S., Riley, A. A., Davis, T. K., Farmer, C., Hogarth, M., Thomas, M., Murray, P. T., Robinson-Cohen, C., Nicoletti, P., Vaingankar, S., Mehta, R. & Awdishu, L., Nov 2023, In: Kidney International Reports. 8, 11, p. 2333-2344 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2022

1400W Prevents Renal Injury in the Renal Cortex But Not in the Medulla in a Murine Model of Ischemia and Reperfusion Injury

Pasten, C., Lozano, M., Méndez, G. P. & Irarrázabal, C. E., 19 Oct 2022, In: Cellular Physiology and Biochemistry. 56, 5, p. 573-586 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

The Ischemia and Reperfusion Injury Involves the Toll-Like Receptor-4 Participation Mainly in the Kidney Cortex

Herrera-Luna, Y., Lozano, M., Pasten, C., Multhoff, G. & Irarrázabal, C. E., 2022, In: Cellular Physiology and Biochemistry. 56, 6, p. 613-628 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Urinary Extracellular Vesicles as a Source of NGAL for Diabetic Kidney Disease Evaluation in Children and Adolescents With Type 1 Diabetes Mellitus

Ugarte, F., Santapau, D., Gallardo, V., Garfias, C., Yizmeyián, A., Villanueva, S., Sepúlveda, C., Rocco, J., Pasten, C., Urquidi, C., Cavada, G., San Martin, P., Cano, F. & Irarrázabal, C. E., 3 Jan 2022, In: Frontiers in Endocrinology. 12, 654269.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2021

Aminoguanidine prevents the oxidative stress, inhibiting elements of inflammation, endothelial activation, mesenchymal markers, and confers a renoprotective effect in renal ischemia and reperfusion injury

Pasten, C., Lozano, M., Rocco, J., Carrión, F., Alvarado, C., Liberona, J., Michea, L. & Irarrázabal, C. E., Nov 2021, In: Antioxidants. 10, 11, 1724.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Glutathione s-transferase and clusterin, new players in the ischemic preconditioning renal protection in a murine model of ischemia and reperfusion

Pasten, C., Herrera-Luna, Y., Lozano, M., Rocco, J., Alvarado, C., Liberona, J. & Irarrázabal, L. M. C. E., 2021, In: Cellular Physiology and Biochemistry. 55, 5, p. 635-650 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2019

Emerging new role of NFAT5 in inducible nitric oxide synthase in response to hypoxia in mouse embryonic fibroblast cells

Serman, Y., Fuentealba, R. A., Pasten, C., Rocco, J., Ko, B. C. B., Carrión, F. & Irarrázabal, C. E., 2019, In: American Journal of Physiology - Cell Physiology. 317, 1, p. C31-C38

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

L-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice

Pasten, C., Alvarado, C., Rocco, J., Contreras, L., Aracena, P., Liberona, J., Suazo, C., Michea, L. & Irarrázabal, C. E., Apr 2019, In: American Journal of Physiology - Renal Physiology. 316, 4, p. F624-F634

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2017

Oxidative damage and nitric oxide synthase induction by surgical uteroplacental circulation restriction in the rabbit fetal heart

Figueroa, H., Alvarado, C., Cifuentes, J., Lozano, M., Rocco, J., Cabezas, C., Illanes, S., Eixarch, E., Hernández-Andrade, E., Gratacós, E. & Irarrazabal Muñoz, C. E., May 2017, In: Prenatal Diagnosis. 37, 5, p. 453-459 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2016

Differential TLR activation of murine mesenchymal stem cells generates distinct immunomodulatory effects in EAE

Vega-Letter, A. M., Kurte, M., Fernández-O'Ryan, C., Gauthier-Abeliuk, M., Fuenzalida, P., Moya-Uribe, I., Altamirano, C., Figueroa, F., Irarrázabal, C. & Carrión, F., 10 Oct 2016, In: Stem Cell Research and Therapy. 7, 1, p. 1-12 12 p., 150.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Impaired phosphorylation of JAK2-STAT5b signaling in fibroblasts from uremic children

Ugarte, F., Irarrazabal, C., Oh, J., Dettmar, A., Ceballos, M. L., Rojo, A., Ibacache, M. J., Suazo, C., Lozano, M., Delgado, I., Cavada, G., Azocar, M., Delucchi, A. & Cano, F., 8 Jan 2016, In: Pediatric Nephrology. 31, 6, p. 965-974 10 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Nitric oxide synthase and changes in oxidative stress levels in embryonic kidney observed in a rabbit model of intrauterine growth restriction

Figueroa, H., Cifuentes, J., Lozano, M., Alvarado, C., Cabezas, C., Eixarch, E., Fernández, E., Contreras, L., Illanes, S., Hernández-Andrade, E., Gratacós, E. & Irarrazabal Muñoz, C. E., 1 Jul 2016, In: Prenatal Diagnosis. 36, 7, p. 628-635 8 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Overexpression of glutamate decarboxylase in mesenchymal stem cells enhances their immunosuppressive properties and increases GABA and nitric oxide levels

Urrutia, M., Fernández, S., González, M., Vilches, R., Rojas, P., Vásquez, M., Kurte, M., Vega-Letter, A. M., Carrión, F., Figueroa, F., Rojas, P., Irarrázabal, C. & Fuentealba, R. A., Sep 2016, In: PLoS ONE. 11, 9, e0163735.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Toll-like receptor 3 pre-conditioning increases the therapeutic efficacy of umbilical cord mesenchymal stromal cells in a dextran sulfate sodium-induced colitis model

Fuenzalida, P., Kurte, M., Fernández-O'ryan, C., Ibañez, C., Gauthier-Abeliuk, M., Vega-Letter, A. M., Gonzalez, P., Irarrázabal, C., Quezada, N., Figueroa, F. & Carrión, F., 1 May 2016, In: Cytotherapy. 18, 5, p. 630-641 12 p.

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

2015

Incidencia de la injuria renal aguda en unidad de paciente crítico y su mortalidad a 30 días y un año

Translated title of the contribution: Incidence and consequences of acute kidney injury among patients admitted to critical care unitsBoltansky Brenner, A., Bassa, C., Melani, S., Sepúlveda, A., Maldonado, I., Postigo, J., Sotta, E., Vidueira, P., Cavagnaro, C., Cavada, G., Benavente, C., Villamizar, G., Vukusich, A. & Irarrázabal, C. E., Sep 2015, In: Revista Medica de Chile. 143, 9, p. 1114-1120 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Intravenous administration of bone marrow-derived mesenchymal stem cells induces a switch from classical to atypical symptoms in experimental autoimmune encephalomyelitis

Kurte, M., Bravo-Alegría, J., Torres, A., Carrasco, V., Ibáñez, C., Vega-Letter, A. M., Fernández-O'Ryan, C., Irarrázabal, C. E., Figueroa, F. E., Fuentealba, R. A., Riedel, C. & Carrión, F., 2015, In: Stem Cells International. 2015, 140170.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

NFAT5 is up-regulated by hypoxia: Possible implications in preeclampsia and intrauterine growth restriction

Dobierzewska, A., Palominos, M., Irarrazabal, C. E., Sanchez, M., Lozano, M., Perez-Sepulveda, A., Monteiro, L. J., Burmeister, Y., Figueroa-Diesel, H., Rice, G. E. & Illanes, S. E., 1 Jul 2015, In: Biology of Reproduction. 93, 1, 14.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Placental aromatase is deficient in placental ischemia and preeclampsia

Perez-Sepulveda, A., Monteiro, L. J., Dobierzewska, A., España-Perrot, P. P., Venegas-Araneda, P., Guzmán-Rojas, A. M., González, M. I., Palominos-Rivera, M., Irarrazabal, C. E., Figueroa-Diesel, H., Varas-Godoy, M. & Illanes, S. E., 7 Oct 2015, In: PLoS ONE. 10, 10, 139682.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

Spironolactone inhibits the activity of the Na⁺/H⁺ exchanger in the aorta of mineralocorticoid-induced hypertensive rats

Carreño, J. E., Verdugo, F. J., Contreras, F., Montellano, F. A., Veloso, S., Schalper, K. A., Sandoval, M., Villanueva, S., Marusic, E. & Irarrazabal, C. E., 1 Dec 2015, In: JRAAS - Journal of the Renin-Angiotensin-Aldosterone System. 16, 4, p. 1225-1231 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2014

Basic fibroblast growth factor reduces functional and structural damage in chronic kidney disease

Villanueva, S., Contreras, F., Tapia, A., Carreño, J. E., Vergara, C., Ewertz, E., Cespedes, C., Irarrazabal, C., Sandoval, M., Velarde, V. & Vio, C. P., 15 Feb 2014, In: American Journal of Physiology - Renal Physiology. 306, 4, p. F430-F441

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Longitudinal FGF23 and Klotho axis characterization in children treated with chronic peritoneal dialysis

Cano, F. J., Freundlich, M., Ceballos, M. L., Rojo, A. P., Azocar, M. A., Delgado, I. O., Ibacache, M. J., Delucchi, M. A., Lillo, A. M., Irarrázabal, C. E. & Ugarte, M. F., 18 Mar 2014, In: Clinical Kidney Journal. 7, 5, p. 457-463 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Mineral metabolism in patients on chronic peritoneal dialysis

Translated title of the contribution: Mineral metabolism in patients on chronic peritoneal dialysisCeballos O., M. L., Rojo L., A., Azócar P., M., Ibacache M., M. J., Delucchi B., A., Quiroz Z., L., Irarrázabal M., C., Delgado B., I., Ugarte P., F. & Cano Sch, F., Feb 2014, In: Revista Chilena de Pediatria. 85, 1, p. 31-39 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2013

Human mesenchymal stem cells derived from adipose tissue reduce functional and tissue damage in a rat model of chronic renal failure

Villanueva, S., Carreño, J. E., Salazar, L., Vergara, C., Strodthoff, R., Fajre, F., Céspedes, C., Sáez, P. J., Irarrázabal, C., Bartolucci, J., Figueroa, F. & Vio, C. P., Aug 2013, In: Clinical Science. 125, 4, p. 199-210 12 p.

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

The mini-PET in pediatric peritoneal dialysis: A useful tool to predict volume overload?

Cano, F., Rojo, A., Azocar, M., Ibacache, M. J., Delucchi, A., Ugarte, F., Irarrazabal, C. & Delgado, I., Jul 2013, In: Pediatric Nephrology. 28, 7, p. 1121-1126 6 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Urinary exosomes as a source of kidney dysfunction biomarker in renal transplantation

Alvarez, S., Suazo, C., Boltansky, A., Ursu, M., Carvajal, D., Innocenti, G., Vukusich, A., Hurtado, M., Villanueva, S., Carreño, J. E., Rogelio, A. & Irarrazabal, C. E., Dec 2013, In: Transplantation Proceedings. 45, 10, p. 3719-3723 5 p.

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

2012

Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure

Villanueva, S., Escobar, P., Jacubovsky, I., Irarrázabal, C., Carreño, J. E., Erpel, J. M., Céspedes, C., González, A. A., Vio, C. P. & Velarde, V., 2012, In: Biological Research. 45, 1, p. 51-60 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction

Ávalos, A. M., Apablaza, F. A., Quiroz, M., Toledo, V., Peña, J. P., Michea, L., Irarrázabal, C. E., Carrión, F. A. & Figueroa, F. E., 2012, In: Biological Research. 45, 2, p. 193-200 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Intrauterine growth restriction modifies the normal gene expression in kidney from rabbit fetuses

Figueroa, H., Lozano, M., Suazo, C., Eixarch, E., Illanes, S., Carreño, J. E., Villanueva, S., Hernández-Andrade, E., Gratacós, E. & Irarrazabal Muñoz, C. E., Nov 2012, In: Early Human Development. 88, 11, p. 899-904 6 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

NFAT5 is activated by hypoxia: role in ischemia and reperfusion in the rat kidney

Villanueva, S., Suazo, C., Santapau, D., Pérez, F., Quiroz, M., Carreño, J. E., Illanes, S., Lavandero, S., Michea, L. & Irarrazabal, C. E., 2 Jul 2012, In: PLoS ONE. 7, 7, e39665.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2011

Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model

Villanueva, S., Ewertz, E., Carrión, F., Tapia, A., Vergara, C., Céspedes, C., Sáez, P. J., Luz, P., Irarrázabal, C., Carreño, J. E., Figueroa, F. & Vio, C. P., Dec 2011, In: Clinical Science. 121, 11, p. 489-499 11 p.

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

2010

Phospholipase C-γ1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP

Irarrazabal, C. E., Gallazzini, M., Schnetz, M. P., Kunin, M., Simons, B. L., Williams, C. K., Burg, M. B. & Ferraris, J. D., 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 2, p. 906-911 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

2009

Association between p53 codon 72 genetic polymorphism and tobacco use and lung cancer risk

Cáceres, D. D., Quiñones, L. A., Schroeder, J. C., Gil, L. D. & Irarrázabal, C. E., Apr 2009, In: Lung. 187, 2, p. 110-115 6 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

1997

Erratum: The binding specificity of amino acid transport system y + L in human erythrocytes is altered by monovalent cations (The Journal of Membrane Biology 153: (1996) (37-44))

Angelo, S., Irarrazabal, C. & Deves, R., 1997, In: Journal of Membrane Biology. 155, 2, p. 187 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

1 Scopus citations

Grupo de Fisiología Integrativa

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