Departamento de Medicina Interna

2025

Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis

Figueroa-Valdés, A. I., Luz-Crawford, P., Herrera-Luna, Y., Georges-Calderón, N., García, C., Tobar, H. E., Araya, M. J., Matas, J., Donoso-Meneses, D., de la Fuente, C., Cuenca, J., Parra, E., Lillo, F., Varela, C., Cádiz, M. I., Vernal, R., Ortloff, A., Nardocci, G., Castañeda, V. & Adasme-Vidal, C. & 5 others, Kunze-Küllmer, M., Hidalgo, Y., Espinoza, F., Khoury, M. & Alcayaga-Miranda, F., 13 Jan 2025, In: Journal of Nanobiotechnology. 23, 1, p. 13 1 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2024

Efficacy of a single dose of cryopreserved human umbilical cord mesenchymal stromal cells for the treatment of knee osteoarthritis:a randomized, controlled, double-blind pilot study

Pico, O. A., Espinoza, F., Cádiz, M. I., Sossa, C. L., Becerra-Bayona, S. M., Salgado, M. C. C., Rodríguez, J. E. R., Cárdenas, O. F. V., Cure, J. M. Q., Khoury, M. & Arango-Rodríguez, M. L., 2024, In: Cytotherapy.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Mitochondrial transfer balances cell redox, energy and metabolic homeostasis in the osteoarthritic chondrocyte preserving cartilage integrity

Court, A. C., Vega-Letter, A. M., Parra-Crisóstomo, E., Velarde, F., García, C., Ortloff, A., Vernal, R., Pradenas, C., Luz-Crawford, P., Khoury, M. & Figueroa, F. E., 2024, In: Theranostics. 14, 17, p. 6471-6486 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Survival advantage of native and engineered T cells is acquired by mitochondrial transfer from mesenchymal stem cells

Court, A. C., Parra-Crisóstomo, E., Castro-Córdova, P., Abdo, L., Aragão, E. A. A., Lorca, R., Figueroa, F. E., Bonamino, M. H. & Khoury, M., Dec 2024, In: Journal of Translational Medicine. 22, 1, p. 868 868.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2022

Trasplante de microbiota fecal por colonoscopía en paciente mayor de 65 años con infección recurrente de Clostridioides difficile: aún una estrategia subutilizada

Translated title of the contribution: Fecal microbiota transplantation in an older patient with Clostridioides difficile recurrent infection: report of one caseNúñez, P., Quera, R., von Muhlenbrock, C., Concha, A. & Flores, K., Oct 2022, In: Revista Medica de Chile. 150, 10, p. 1396-1400 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response

Court, A. C., Le-Gatt, A., Luz-Crawford, P., Parra, E., Aliaga-Tobar, V., Bátiz, L. F., Contreras, R. A., Ortúzar, M. I., Kurte, M., Elizondo-Vega, R., Maracaja-Coutinho, V., Pino-Lagos, K., Figueroa, F. E. & Khoury, M., 5 Feb 2020, In: EMBO Reports. 21, 2, e48052.

Research output: Contribution to journal › Article › peer-review

Open Access

167 Scopus citations

2019

Adipose tissue-derived mesenchymal stromal cells in patients with chronic kidney disease: A pilot study assessing safety and clinical feasibility

Villanueva, S., González, F., Lorca, E., Tapia, A., Valentina López, G., Strodthoff, R., Fajre, F., Carreño, J. E., Valjalo, R., Vergara, C., Lecanda, M., Bartolucci, J., Figueroa, F. E. & Khoury, M., 2019, In: Kidney Research and Clinical Practice. 38, 2, p. 176-185 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial

Matas, J., Orrego, M., Amenabar, D., Infante, C., Tapia-Limonchi, R., Cadiz, M. I., Alcayaga-Miranda, F., González, P. L., Muse, E., Khoury, M., Figueroa, F. E. & Espinoza, F., Mar 2019, In: Stem cells translational medicine. 8, 3, p. 215-224 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

273 Scopus citations

2018

IL17/IL17RA as a novel signaling axis driving mesenchymal stem cell therapeutic function in experimental autoimmune encephalomyelitis

Kurte, M., Luz-Crawford, P., Vega-Letter, A. M., Contreras, R. A., Tejedor, G., Elizondo-Vega, R., Martinez-Viola, L., Fernández-O'Ryan, C., Figueroa, F. E., Jorgensen, C., Djouad, F. & Carrión, F., 30 Apr 2018, In: Frontiers in Immunology. 9, APR, 802.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Implementación de una unidad de artritis reumatoide temprana en pacientes chilenos derivados desde centros de atención primaria de salud

Translated title of the contribution: Implementation of an early rheumatoid athritis unit for the early recognition and treatment of the diseaseEspinoza, F., Monckeberg, G., Hassi, I., Queirolo, A., Chicao, F., Sandoval, X., Jorquera, E. & Badilla, A., Jan 2018, In: Revista Medica de Chile. 146, 1, p. 39-45 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Injection of adipose-derived stromal cells in the knee of patients with severe osteoarthritis has a systemic effect and promotes an anti-inflammatory phenotype of circulating immune cells

Pers, Y. M., Quentin, J., Feirreira, R., Espinoza, F., Abdellaoui, N., Erkilic, N., Cren, M., Dufourcq-Lopez, E., Pullig, O., Nöth, U., Jorgensen, C. & Louis-Plence, P., 2018, In: Theranostics. 8, 20, p. 5519-5528 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

2017

Biologic disease-modifying antirheumatic drug (bdmard)-induced neutropenia: A registry from a retrospective cohort of patients with rheumatic diseases treated with 3 classes of intravenous bdmard

Espinoza, F., Le Blay, P. & Combe, B., 1 Jun 2017, In: Journal of Rheumatology. 44, 6, p. 844-849 6 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Safety and efficacy of the intravenous infusion of umbilical cord mesenchymal stem cells in patients with heart failure: A phase 1/2 randomized controlled trial (RIMECARD trial [Randomized clinical trial of intravenous infusion umbilical cord mesenchymal stem cells on cardiopathy])

Bartolucci, J., Verdugo, F. J., González, P. L., Larrea, R. E., Abarzua, E., Goset, C., Rojo, P., Palma, I., Lamich, R., Pedreros, P. A., Valdivia, G., Lopez, V. M., Nazzal, C., Alcayaga-Miranda, F., Cuenca, J., Brobeck, M. J., Patel, A. N., Figueroa, F. E. & Khoury, M., 2017, In: Circulation Research. 121, 10, p. 1192-1204 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

349 Scopus citations

2016

Differential TLR activation of murine mesenchymal stem cells generates distinct immunomodulatory effects in EAE

Vega-Letter, A. M., Kurte, M., Fernández-O'Ryan, C., Gauthier-Abeliuk, M., Fuenzalida, P., Moya-Uribe, I., Altamirano, C., Figueroa, F., Irarrázabal, C. & Carrión, F., 10 Oct 2016, In: Stem Cell Research and Therapy. 7, 1, p. 1-12 12 p., 150.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Overexpression of glutamate decarboxylase in mesenchymal stem cells enhances their immunosuppressive properties and increases GABA and nitric oxide levels

Urrutia, M., Fernández, S., González, M., Vilches, R., Rojas, P., Vásquez, M., Kurte, M., Vega-Letter, A. M., Carrión, F., Figueroa, F., Rojas, P., Irarrázabal, C. & Fuentealba, R. A., Sep 2016, In: PLoS ONE. 11, 9, e0163735.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

The immunosuppressive signature of menstrual blood mesenchymal stem cells entails opposite effects on experimental arthritis and graft versus host diseases

Luz-Crawford, P., Torres, M. J., Noël, D., Fernandez, A., Toupet, K., Alcayaga-Miranda, F., Tejedor, G., Jorgensen, C., Illanes, S. E., Figueroa, F. E., Djouad, F. & Khoury, M., 1 Feb 2016, In: Stem Cells. 34, 2, p. 456-469 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

68 Scopus citations

Toll-like receptor 3 pre-conditioning increases the therapeutic efficacy of umbilical cord mesenchymal stromal cells in a dextran sulfate sodium-induced colitis model

Fuenzalida, P., Kurte, M., Fernández-O'ryan, C., Ibañez, C., Gauthier-Abeliuk, M., Vega-Letter, A. M., Gonzalez, P., Irarrázabal, C., Quezada, N., Figueroa, F. & Carrión, F., 1 May 2016, In: Cytotherapy. 18, 5, p. 630-641 12 p.

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

2015

Characterization of menstrual stem cells: Angiogenic effect, migration and hematopoietic stem cell support in comparison with bone marrow mesenchymal stem cells

Alcayaga-Miranda, F., Cuenca, J., Luz-Crawford, P., Aguila-Díaz, C., Fernandez, A., Figueroa, F. E. & Khoury, M., 17 Mar 2015, In: Stem Cell Research and Therapy. 6, 1, 32.

Research output: Contribution to journal › Article › peer-review

Open Access

135 Scopus citations

Chorion mesenchymal stem cells show superior differentiation, immunosuppressive, and angiogenic potentials in comparison with haploidentical maternal placental cells

González, P. L., Carvajal, C., Cuenca, J., Alcayaga-Miranda, F., Figueroa, F. E., Bartolucci, J., Salazar-Aravena, L. & Khoury, M., 1 Oct 2015, In: Stem cells translational medicine. 4, 10, p. 1109-1121 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

73 Scopus citations

Combination therapy of menstrual derived mesenchymal stem cells and antibiotics ameliorates survival in sepsis

Alcayaga-Miranda, F., Cuenca, J., Martin, A., Contreras, L., Figueroa, F. E. & Khoury, M., 16 Oct 2015, In: Stem Cell Research and Therapy. 6, 1, 199.

Research output: Contribution to journal › Article › peer-review

Open Access

124 Scopus citations

Intravenous administration of bone marrow-derived mesenchymal stem cells induces a switch from classical to atypical symptoms in experimental autoimmune encephalomyelitis

Kurte, M., Bravo-Alegría, J., Torres, A., Carrasco, V., Ibáñez, C., Vega-Letter, A. M., Fernández-O'Ryan, C., Irarrázabal, C. E., Figueroa, F. E., Fuentealba, R. A., Riedel, C. & Carrión, F., 2015, In: Stem Cells International. 2015, 140170.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Microrna profiling of b cell subsets from systemic lupus erythematosus patients reveals promising novel biomarkers

Duroux-Richard, I., Cuenca, J., Ponsolles, C., Piñeiro, A. B., Gonzalez, F., Roubert, C., Areny, R., Chea, R., Pefaur, J., Pers, Y. M., Figueroa, F. E., Jorgensen, C., Khoury, M. & Apparailly, F., 2015, In: International Journal of Molecular Sciences. 16, 8, p. 16953-16965 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Resultados a largo plazo del trasplante intracoronario de células mononucleares de médula ósea autólogas en pacientes con cardiopatía dilatada de diversa etiología

Translated title of the contribution: Long-term results of intracoronary transplantation of autologous bone marrow cells in dilated cardiomyopathyBartolucci, J., Verdugo, F. J., Carrion, F., Abarzúa, E., Goset, C., Lamich, R., Sanhueza, P., Pedreros, P., Nazzal, C., Khoury, M. & Figueroa, F. E., 2015, In: Revista Medica de Chile. 143, 4, p. 415-423 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2014

Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes

Amador, C. A., Barrientos, V., Peña, J., Herrada, A. A., González, M., Valdés, S., Carrasco, L., Alzamora, R., Figueroa, F., Kalergis, A. M. & Michea, L., Apr 2014, In: Hypertension. 63, 4, p. 797-803 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

176 Scopus citations

2013

Human mesenchymal stem cells derived from adipose tissue reduce functional and tissue damage in a rat model of chronic renal failure

Villanueva, S., Carreño, J. E., Salazar, L., Vergara, C., Strodthoff, R., Fajre, F., Céspedes, C., Sáez, P. J., Irarrázabal, C., Bartolucci, J., Figueroa, F. & Vio, C. P., Aug 2013, In: Clinical Science. 125, 4, p. 199-210 12 p.

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Mesenchymal stem cells generate a CD4⁺CD25⁺Foxp3 ⁺ regulatory T cell population during the differentiation process of Th1 and Th17 cells

Luz-Crawford, P., Kurte, M., Bravo-Alegría, J., Contreras, R., Nova-Lamperti, E., Tejedor, G., Noël, D., Jorgensen, C., Figueroa, F., Djouad, F. & Carrión, F., 2013, In: Stem Cell Research and Therapy. 4, 3, 65.

Research output: Contribution to journal › Article › peer-review

Open Access

406 Scopus citations

2012

Assesment of arterial damage by noninvasive peripheral arterial tonometry in non-diabetic hemodialysis patients

Translated title of the contribution: Assesment of arterial damage by noninvasive peripheral arterial tonometry in non-diabetic hemodialysis patientsEspinoza, F., Kunstmann, S., Urzúa, A., Michea, L., Marusic, E. T. & Vukusich, A., Feb 2012, In: Revista Medica de Chile. 140, 2, p. 153-160 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction

Ávalos, A. M., Apablaza, F. A., Quiroz, M., Toledo, V., Peña, J. P., Michea, L., Irarrázabal, C. E., Carrión, F. A. & Figueroa, F. E., 2012, In: Biological Research. 45, 2, p. 193-200 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Mesenchymal Stem Cells Repress Th17 Molecular Program through the PD-1 Pathway

Luz-Crawford, P., Noël, D., Fernandez, X., Khoury, M., Figueroa, F., Carrión, F., Jorgensen, C. & Djouad, F., 17 Sep 2012, In: PLoS ONE. 7, 9, e45272.

Research output: Contribution to journal › Article › peer-review

Open Access

159 Scopus citations

Mesenchymal Stem Cell treatment for autoimmune diseases: A critical review

Figueroa, F. E., Carrión, F., Villanueva, S. & Khoury, M., 2012, In: Biological Research. 45, 3, p. 269-277 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

142 Scopus citations

2011

Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model

Villanueva, S., Ewertz, E., Carrión, F., Tapia, A., Vergara, C., Céspedes, C., Sáez, P. J., Luz, P., Irarrázabal, C., Carreño, J. E., Figueroa, F. & Vio, C. P., Dec 2011, In: Clinical Science. 121, 11, p. 489-499 11 p.

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4 ⁺ T cell activation.

Carrión, F., Nova, E., Luz, P., Apablaza, F. & Figueroa, F., 30 Mar 2011, In: Immunology Letters. 135, 1-2, p. 10-16 7 p.

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

2010

Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity

Herrada, A. A., Contreras, F. J., Marini, N. P., Amador, C. A., González, P. A., Cortés, C. M., Riedel, C. A., Carvajal, C. A., Figueroa, F., Michea, L. F., Fardella, C. E. & Kalergis, A. M., 1 Jan 2010, In: Journal of Immunology. 184, 1, p. 191-202 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

158 Scopus citations

2009

Infections in patients with systemic lupus erythematosus

Enberg G., M., Kahn C., M., Goity F., C., Villalón S., M. V., Zamorano R., J. & Figueroa E., F., 1 Oct 2009, In: Revista Medica de Chile. 137, 10, p. 1367-1374 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2007

Patient self-administered joint tenderness counts in rheumatoid arthritis are reliable and responsive to changes in disease activity

Figueroa, F., Braun-Moscovici, Y., Khanna, D., Voon, E., Gallardo, L., Luinstra, D., Pina, X., Henstorf, G., Laurence, S., Neiman, R. & Furst, D., 1 Jan 2007, In: Journal of Rheumatology. 34, 1, p. 54-56 3 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Presence of bacterial DNA in valvular tissue of patients with rheumatic heart disease

Figueroa, F. E., Carrión A, F., Valenzuela M, S., Turner G, E., Aceitón E, C., Hirigoyen P, C., Bogdanic W, K., Solís D, C., Mansilla A, K. & Urra G, S., 1 Aug 2007, In: Revista Medica de Chile. 135, 8, p. 959-966 8 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Successful treatment of thrombotic thrombocytopenic purpura with vincristine report of one case

Espinoza, F., Leal Fernández, J. L. & Arenas, G., 1 Dec 2007, In: Revista Medica de Chile. 135, 12, p. 1572-1576 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2006

Na ⁺-K ⁺-2Cl ^- cotransporter is implicated in gender differences in the response of the rat aorta to phenylephrine

Palacios, J., Espinoza, F., Munita, C., Cifuentes, F. & Michea, L., 12 Aug 2006, In: British Journal of Pharmacology. 148, 7, p. 964-972 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2003

Polymorphisms of Fcγlla receptors in Chilean patients with systemic lupus erythematosus

Carrión A, F., Figueroa E, F., Martínez R, M. E., Massardo V, L., Pérez G, T., Foster B, C., Mancilla M, C., Neira Q, O., Guzmán B, L., Valenzuela M, V., Urrutia L, R., Carmona G, S., Figueroa, M., Lubiano A, A. & Wainstein G, E., 1 Jan 2003, In: Revista Medica de Chile. 131, 1, p. 11-18 8 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Selective depletion of Vβ2+CD8+ T cells in peripheral blood from rheumatic heart disease patients

Carrión, F., Fernandez, M., Iruretagoyena, M., Coelho Andrade, L. E., Odete-Hilário, M. & Figueroa, F., Mar 2003, In: Journal of Autoimmunity. 20, 2, p. 183-190 8 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2002

Eosinophilic fasciitis: Report of three cases

Velásquez G, X., Gutiérrez T, M. A., Rosenberg G, H., Figueroa E, F., Bronstein A, E. & Jacobelli G., S., 1 Feb 2002, In: Revista Medica de Chile. 130, 2, p. 209-214 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Restriction in the usage of variable β regions in T-cells infiltrating valvular tissue from rheumatic heart disease patients

Figueroa, F., González, M., Carrión, F., Lobos, C., Turner, F., Lasagna, N. & Valdés, F., Dec 2002, In: Journal of Autoimmunity. 19, 4, p. 233-240 8 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2001

Prospective comparison of clinical and echocardiographic diagnosis of rheumatic carditis: Long term follow up of patients with subclinical disease

Figueroa, F. E., Valdés, P., Carrión, F., Valdés, F., Soledad Fernández, M., Wilson, C., Berríos, X. & Lanas, F., 2001, In: Heart. 85, 4, p. 407-410 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

96 Scopus citations

2000

La inmunología clínica actual: una perspectiva genética y molecular

Carrión A, F., Figueroa, F. E. & Rodríguez G, C., 1 Jun 2000, In: Revista Medica de Chile. 128, 6, p. 650-658 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

1998

Efectos de la bromocriptina en pacientes con artritis reumatoide activa

Translated title of the contribution: Effects of bromocriptine in patients with active rheumatoid arthritisFigueroa E, F., Carrión A, F., Martínez R, M. E., Rivero D, S., Mamani V, I. & González V, G., Jan 1998, In: Revista Medica de Chile. 126, 1, p. 33-41 9 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

1996

Association of primary antiphospholipid syndrome with primary adrenal insufficiency

González, G., Gutiérrez, M., Ortiz, M., Tellez, R., Figueroa, F. & Jacobelli, S., 1 Aug 1996, In: Journal of Rheumatology. 23, 7, p. 1286-1287 2 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

1992

Anticardiolipin antibodies in acute rheumatic fever

Figueroa, F., Berrios, X., Gutierrez, M., Carrion, F., Pablo Goycolea, J., Riedel, I. & Jacobelli, S., 1992, In: Journal of Rheumatology. 19, 8, p. 1175-1180 6 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Departamento de Medicina Interna

Research output

Search results