Departamento de Medicina Interna

2022

Trasplante de microbiota fecal por colonoscopía en paciente mayor de 65 años con infección recurrente de Clostridioides difficile: aún una estrategia subutilizada

Translated title of the contribution: Fecal microbiota transplantation in an older patient with Clostridioides difficile recurrent infection: report of one caseNúñez, P., Quera, R., von Muhlenbrock, C., Concha, A. & Flores, K., Oct 2022, In: Revista Medica de Chile. 150, 10, p. 1396-1400 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19

Khoury, M., Cuenca, J., Cruz, F. F., Figueroa, F. E., Rocco, P. R. M. & Weiss, D. J., 1 Jun 2020, In: European Respiratory Journal. 55, 6, 2000858.

Research output: Contribution to journal › Review article › peer-review

Open Access

193 Scopus citations

Magic realism: a Latin American paradigm for stem cell research & development?

Khoury, M. & Figueroa, F. E., 1 Feb 2020, In: Gene Therapy. 27, 1-2, p. 2-5 4 p.

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response

Court, A. C., Le-Gatt, A., Luz-Crawford, P., Parra, E., Aliaga-Tobar, V., Bátiz, L. F., Contreras, R. A., Ortúzar, M. I., Kurte, M., Elizondo-Vega, R., Maracaja-Coutinho, V., Pino-Lagos, K., Figueroa, F. E. & Khoury, M., 5 Feb 2020, In: EMBO Reports. 21, 2, e48052.

Research output: Contribution to journal › Article › peer-review

Open Access

146 Scopus citations

2019

Adipose tissue-derived mesenchymal stromal cells in patients with chronic kidney disease: A pilot study assessing safety and clinical feasibility

Villanueva, S., González, F., Lorca, E., Tapia, A., Valentina López, G., Strodthoff, R., Fajre, F., Carreño, J. E., Valjalo, R., Vergara, C., Lecanda, M., Bartolucci, J., Figueroa, F. E. & Khoury, M., 2019, In: Kidney Research and Clinical Practice. 38, 2, p. 176-185 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Mesenchymal stem cells improve rheumatoid arthritis progression by controlling memory T cell response

Luque-Campos, N., Contreras-López, R. A., Paredes-Martínez, M. J., Torres, M. J., Bahraoui, S., Wei, M., Espinoza, F., Djouad, F., Elizondo-Vega, R. J. & Luz Crawford, P. A., 2019, In: Frontiers in Immunology. 10, MAR, 798.

Research output: Contribution to journal › Review article › peer-review

Open Access

92 Scopus citations

Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial

Matas, J., Orrego, M., Amenabar, D., Infante, C., Tapia-Limonchi, R., Cadiz, M. I., Alcayaga-Miranda, F., González, P. L., Muse, E., Khoury, M., Figueroa, F. E. & Espinoza, F., Mar 2019, In: Stem cells translational medicine. 8, 3, p. 215-224 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

237 Scopus citations

2018

IL17/IL17RA as a novel signaling axis driving mesenchymal stem cell therapeutic function in experimental autoimmune encephalomyelitis

Kurte, M., Luz-Crawford, P., Vega-Letter, A. M., Contreras, R. A., Tejedor, G., Elizondo-Vega, R., Martinez-Viola, L., Fernández-O'Ryan, C., Figueroa, F. E., Jorgensen, C., Djouad, F. & Carrión, F., 30 Apr 2018, In: Frontiers in Immunology. 9, APR, 802.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Implementación de una unidad de artritis reumatoide temprana en pacientes chilenos derivados desde centros de atención primaria de salud

Translated title of the contribution: Implementation of an early rheumatoid athritis unit for the early recognition and treatment of the diseaseEspinoza, F., Monckeberg, G., Hassi, I., Queirolo, A., Chicao, F., Sandoval, X., Jorquera, E. & Badilla, A., Jan 2018, In: Revista Medica de Chile. 146, 1, p. 39-45 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Injection of adipose-derived stromal cells in the knee of patients with severe osteoarthritis has a systemic effect and promotes an anti-inflammatory phenotype of circulating immune cells

Pers, Y. M., Quentin, J., Feirreira, R., Espinoza, F., Abdellaoui, N., Erkilic, N., Cren, M., Dufourcq-Lopez, E., Pullig, O., Nöth, U., Jorgensen, C. & Louis-Plence, P., 2018, In: Theranostics. 8, 20, p. 5519-5528 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

2017

Biologic disease-modifying antirheumatic drug (bdmard)-induced neutropenia: A registry from a retrospective cohort of patients with rheumatic diseases treated with 3 classes of intravenous bdmard

Espinoza, F., Le Blay, P. & Combe, B., 1 Jun 2017, In: Journal of Rheumatology. 44, 6, p. 844-849 6 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Safety and efficacy of the intravenous infusion of umbilical cord mesenchymal stem cells in patients with heart failure: A phase 1/2 randomized controlled trial (RIMECARD trial [Randomized clinical trial of intravenous infusion umbilical cord mesenchymal stem cells on cardiopathy])

Bartolucci, J., Verdugo, F. J., González, P. L., Larrea, R. E., Abarzua, E., Goset, C., Rojo, P., Palma, I., Lamich, R., Pedreros, P. A., Valdivia, G., Lopez, V. M., Nazzal, C., Alcayaga-Miranda, F., Cuenca, J., Brobeck, M. J., Patel, A. N., Figueroa, F. E. & Khoury, M., 2017, In: Circulation Research. 121, 10, p. 1192-1204 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

325 Scopus citations

2016

Differential TLR activation of murine mesenchymal stem cells generates distinct immunomodulatory effects in EAE

Vega-Letter, A. M., Kurte, M., Fernández-O'Ryan, C., Gauthier-Abeliuk, M., Fuenzalida, P., Moya-Uribe, I., Altamirano, C., Figueroa, F., Irarrázabal, C. & Carrión, F., 10 Oct 2016, In: Stem Cell Research and Therapy. 7, 1, p. 1-12 12 p., 150.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Escenario actual y perspectivas de la terapia con células madre mesenquimales en medicina intensiva

Translated title of the contribution: Overview and perspectives of mesenchymal stem cell therapy in intensive care medicineEspinoza, F., Aliaga, F. & Crawford, P. L., Feb 2016, In: Revista Medica de Chile. 144, 2, p. 222-231 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

6 Scopus citations

Mesenchymal stem cells and their immunosuppressive role in transplantation tolerance

Contreras-Kallens, P., Terraza, C., Oyarce, K., Gajardo, T., Campos-Mora, M., Barroilhet, M. T., Álvarez, C., Fuentes, R., Figueroa, F., Khoury, M. & Pino-Lagos, K., 2016, In: Annals of the New York Academy of Sciences. 1417, 1, p. 35-56 22 p.

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune Responses Dampening Arthritis Progression

Contreras, R. A., Figueroa, F. E., Djouad, F. & Luz-Crawford, P., 2016, In: Stem Cells International. 2016, 3162743.

Research output: Contribution to journal › Review article › peer-review

Open Access

32 Scopus citations

Overexpression of glutamate decarboxylase in mesenchymal stem cells enhances their immunosuppressive properties and increases GABA and nitric oxide levels

Urrutia, M., Fernández, S., González, M., Vilches, R., Rojas, P., Vásquez, M., Kurte, M., Vega-Letter, A. M., Carrión, F., Figueroa, F., Rojas, P., Irarrázabal, C. & Fuentealba, R. A., Sep 2016, In: PLoS ONE. 11, 9, e0163735.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Remission-induction therapies for early rheumatoid arthritis: evidence to date and clinical implications

Espinoza, F., Fabre, S. & Pers, Y. M., 1 Aug 2016, In: Therapeutic Advances in Musculoskeletal Disease. 8, 4, p. 107-118 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

26 Scopus citations

The immunosuppressive signature of menstrual blood mesenchymal stem cells entails opposite effects on experimental arthritis and graft versus host diseases

Luz-Crawford, P., Torres, M. J., Noël, D., Fernandez, A., Toupet, K., Alcayaga-Miranda, F., Tejedor, G., Jorgensen, C., Illanes, S. E., Figueroa, F. E., Djouad, F. & Khoury, M., 1 Feb 2016, In: Stem Cells. 34, 2, p. 456-469 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Toll-like receptor 3 pre-conditioning increases the therapeutic efficacy of umbilical cord mesenchymal stromal cells in a dextran sulfate sodium-induced colitis model

Fuenzalida, P., Kurte, M., Fernández-O'ryan, C., Ibañez, C., Gauthier-Abeliuk, M., Vega-Letter, A. M., Gonzalez, P., Irarrázabal, C., Quezada, N., Figueroa, F. & Carrión, F., 1 May 2016, In: Cytotherapy. 18, 5, p. 630-641 12 p.

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

2015

Characterization of menstrual stem cells: Angiogenic effect, migration and hematopoietic stem cell support in comparison with bone marrow mesenchymal stem cells

Alcayaga-Miranda, F., Cuenca, J., Luz-Crawford, P., Aguila-Díaz, C., Fernandez, A., Figueroa, F. E. & Khoury, M., 17 Mar 2015, In: Stem Cell Research and Therapy. 6, 1, 32.

Research output: Contribution to journal › Article › peer-review

Open Access

128 Scopus citations

Chorion mesenchymal stem cells show superior differentiation, immunosuppressive, and angiogenic potentials in comparison with haploidentical maternal placental cells

González, P. L., Carvajal, C., Cuenca, J., Alcayaga-Miranda, F., Figueroa, F. E., Bartolucci, J., Salazar-Aravena, L. & Khoury, M., 1 Oct 2015, In: Stem cells translational medicine. 4, 10, p. 1109-1121 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Combination therapy of menstrual derived mesenchymal stem cells and antibiotics ameliorates survival in sepsis

Alcayaga-Miranda, F., Cuenca, J., Martin, A., Contreras, L., Figueroa, F. E. & Khoury, M., 16 Oct 2015, In: Stem Cell Research and Therapy. 6, 1, 199.

Research output: Contribution to journal › Article › peer-review

Open Access

116 Scopus citations

Intravenous administration of bone marrow-derived mesenchymal stem cells induces a switch from classical to atypical symptoms in experimental autoimmune encephalomyelitis

Kurte, M., Bravo-Alegría, J., Torres, A., Carrasco, V., Ibáñez, C., Vega-Letter, A. M., Fernández-O'Ryan, C., Irarrázabal, C. E., Figueroa, F. E., Fuentealba, R. A., Riedel, C. & Carrión, F., 2015, In: Stem Cells International. 2015, 140170.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Microrna profiling of b cell subsets from systemic lupus erythematosus patients reveals promising novel biomarkers

Duroux-Richard, I., Cuenca, J., Ponsolles, C., Piñeiro, A. B., Gonzalez, F., Roubert, C., Areny, R., Chea, R., Pefaur, J., Pers, Y. M., Figueroa, F. E., Jorgensen, C., Khoury, M. & Apparailly, F., 2015, In: International Journal of Molecular Sciences. 16, 8, p. 16953-16965 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Resultados a largo plazo del trasplante intracoronario de células mononucleares de médula ósea autólogas en pacientes con cardiopatía dilatada de diversa etiología

Translated title of the contribution: Long-term results of intracoronary transplantation of autologous bone marrow cells in dilated cardiomyopathyBartolucci, J., Verdugo, F. J., Carrion, F., Abarzúa, E., Goset, C., Lamich, R., Sanhueza, P., Pedreros, P., Nazzal, C., Khoury, M. & Figueroa, F. E., 2015, In: Revista Medica de Chile. 143, 4, p. 415-423 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2014

Estado actual de la terapia con células madre en el tratamiento de las cardiopatías

Translated title of the contribution: Stem cells for the treatment of cardiovascular diseases. An updateBartolucci Johnston, J., Verdugo, F. J., Larrea, R., Carrión, F., Lamich, R., Pedreros, P., Delgado, M., Sanhueza, P., Khoury, M. & Figueroa, F. E., 2014, In: Revista Medica de Chile. 142, 8, p. 1034-1046 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

Novel approaches to lupus drug discovery using stem cell therapy. Role of mesenchymal-stem-cell-secreted factors

Figueroa, F. E., Cuenca Moreno, J. & La Cava, A., May 2014, In: Expert Opinion on Drug Discovery. 9, 5, p. 555-566 12 p.

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes

Amador, C. A., Barrientos, V., Peña, J., Herrada, A. A., González, M., Valdés, S., Carrasco, L., Alzamora, R., Figueroa, F., Kalergis, A. M. & Michea, L., Apr 2014, In: Hypertension. 63, 4, p. 797-803 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

171 Scopus citations

The promising potential of menstrual stem cells for antenatal diagnosis and cell therapy

Khoury, M., Alcayaga-Miranda, F., Illanes, S. E. & Figueroa, F. E., 2014, In: Frontiers in Immunology. 5, MAY, 205.

Research output: Contribution to journal › Review article › peer-review

Open Access

76 Scopus citations

2013

Human mesenchymal stem cells derived from adipose tissue reduce functional and tissue damage in a rat model of chronic renal failure

Villanueva, S., Carreño, J. E., Salazar, L., Vergara, C., Strodthoff, R., Fajre, F., Céspedes, C., Sáez, P. J., Irarrázabal, C., Bartolucci, J., Figueroa, F. & Vio, C. P., Aug 2013, In: Clinical Science. 125, 4, p. 199-210 12 p.

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Mesenchymal stem cells generate a CD4⁺CD25⁺Foxp3 ⁺ regulatory T cell population during the differentiation process of Th1 and Th17 cells

Luz-Crawford, P., Kurte, M., Bravo-Alegría, J., Contreras, R., Nova-Lamperti, E., Tejedor, G., Noël, D., Jorgensen, C., Figueroa, F., Djouad, F. & Carrión, F., 2013, In: Stem Cell Research and Therapy. 4, 3, 65.

Research output: Contribution to journal › Article › peer-review

Open Access

392 Scopus citations

Pregnancy during dialysis. Experience in six patients

Translated title of the contribution: Pregnancy during dialysis. Experience in six patients: Experiencia de un único centroEspinoza, F., Romeo, R., Ursu, M., Tapia, A. & Vukusich, A., 2013, In: Revista Medica de Chile. 141, 8, p. 1003-1009 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

11 Scopus citations

2012

Assesment of arterial damage by noninvasive peripheral arterial tonometry in non-diabetic hemodialysis patients

Translated title of the contribution: Assesment of arterial damage by noninvasive peripheral arterial tonometry in non-diabetic hemodialysis patientsEspinoza, F., Kunstmann, S., Urzúa, A., Michea, L., Marusic, E. T. & Vukusich, A., Feb 2012, In: Revista Medica de Chile. 140, 2, p. 153-160 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction

Ávalos, A. M., Apablaza, F. A., Quiroz, M., Toledo, V., Peña, J. P., Michea, L., Irarrázabal, C. E., Carrión, F. A. & Figueroa, F. E., 2012, In: Biological Research. 45, 2, p. 193-200 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Mesenchymal Stem Cells Repress Th17 Molecular Program through the PD-1 Pathway

Luz-Crawford, P., Noël, D., Fernandez, X., Khoury, M., Figueroa, F., Carrión, F., Jorgensen, C. & Djouad, F., 17 Sep 2012, In: PLoS ONE. 7, 9, e45272.

Research output: Contribution to journal › Article › peer-review

Open Access

156 Scopus citations

Mesenchymal Stem Cell treatment for autoimmune diseases: A critical review

Figueroa, F. E., Carrión, F., Villanueva, S. & Khoury, M., 2012, In: Biological Research. 45, 3, p. 269-277 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

138 Scopus citations

2011

Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model

Villanueva, S., Ewertz, E., Carrión, F., Tapia, A., Vergara, C., Céspedes, C., Sáez, P. J., Luz, P., Irarrázabal, C., Carreño, J. E., Figueroa, F. & Vio, C. P., Dec 2011, In: Clinical Science. 121, 11, p. 489-499 11 p.

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Mesenchymal stem cells for the treatment of systemic lupus erythematosus: is the cure for connective tissue diseases within connective tissue?

Carrion, F. A. & Figueroa, F. E., 2011, In: Stem Cell Research and Therapy. 2, 3, 23.

Research output: Contribution to journal › Review article › peer-review

Open Access

34 Scopus citations

Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4 ⁺ T cell activation.

Carrión, F., Nova, E., Luz, P., Apablaza, F. & Figueroa, F., 30 Mar 2011, In: Immunology Letters. 135, 1-2, p. 10-16 7 p.

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

2010

Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity

Herrada, A. A., Contreras, F. J., Marini, N. P., Amador, C. A., González, P. A., Cortés, C. M., Riedel, C. A., Carvajal, C. A., Figueroa, F., Michea, L. F., Fardella, C. E. & Kalergis, A. M., 1 Jan 2010, In: Journal of Immunology. 184, 1, p. 191-202 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

151 Scopus citations

2009

Infections in patients with systemic lupus erythematosus

Enberg G., M., Kahn C., M., Goity F., C., Villalón S., M. V., Zamorano R., J. & Figueroa E., F., 1 Oct 2009, In: Revista Medica de Chile. 137, 10, p. 1367-1374 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2007

Patient self-administered joint tenderness counts in rheumatoid arthritis are reliable and responsive to changes in disease activity

Figueroa, F., Braun-Moscovici, Y., Khanna, D., Voon, E., Gallardo, L., Luinstra, D., Pina, X., Henstorf, G., Laurence, S., Neiman, R. & Furst, D., 1 Jan 2007, In: Journal of Rheumatology. 34, 1, p. 54-56 3 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Presence of bacterial DNA in valvular tissue of patients with rheumatic heart disease

Figueroa, F. E., Carrión A, F., Valenzuela M, S., Turner G, E., Aceitón E, C., Hirigoyen P, C., Bogdanic W, K., Solís D, C., Mansilla A, K. & Urra G, S., 1 Aug 2007, In: Revista Medica de Chile. 135, 8, p. 959-966 8 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Successful treatment of thrombotic thrombocytopenic purpura with vincristine report of one case

Espinoza, F., Leal Fernández, J. L. & Arenas, G., 1 Dec 2007, In: Revista Medica de Chile. 135, 12, p. 1572-1576 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2006

Na ⁺-K ⁺-2Cl ^- cotransporter is implicated in gender differences in the response of the rat aorta to phenylephrine

Palacios, J., Espinoza, F., Munita, C., Cifuentes, F. & Michea, L., 12 Aug 2006, In: British Journal of Pharmacology. 148, 7, p. 964-972 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2003

Polymorphisms of Fcγlla receptors in Chilean patients with systemic lupus erythematosus

Carrión A, F., Figueroa E, F., Martínez R, M. E., Massardo V, L., Pérez G, T., Foster B, C., Mancilla M, C., Neira Q, O., Guzmán B, L., Valenzuela M, V., Urrutia L, R., Carmona G, S., Figueroa, M., Lubiano A, A. & Wainstein G, E., 1 Jan 2003, In: Revista Medica de Chile. 131, 1, p. 11-18 8 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Selective depletion of Vβ2+CD8+ T cells in peripheral blood from rheumatic heart disease patients

Carrión, F., Fernandez, M., Iruretagoyena, M., Coelho Andrade, L. E., Odete-Hilário, M. & Figueroa, F., Mar 2003, In: Journal of Autoimmunity. 20, 2, p. 183-190 8 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2002

Eosinophilic fasciitis: Report of three cases

Velásquez G, X., Gutiérrez T, M. A., Rosenberg G, H., Figueroa E, F., Bronstein A, E. & Jacobelli G., S., 1 Feb 2002, In: Revista Medica de Chile. 130, 2, p. 209-214 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Restriction in the usage of variable β regions in T-cells infiltrating valvular tissue from rheumatic heart disease patients

Figueroa, F., González, M., Carrión, F., Lobos, C., Turner, F., Lasagna, N. & Valdés, F., Dec 2002, In: Journal of Autoimmunity. 19, 4, p. 233-240 8 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Departamento de Medicina Interna

Research output

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