Centro de Investigación e Innovación Biomédica

Projects

Projects per year 1999 2012 2013 2017 2019 2020 2021 2023 2031

• 4 Not started
• 28 Active
• 94 Finished

Projects per year

Search results

• Active

  FONDECYT REGULAR - 1241103: DECIPHERING THE ROLE OF MITOCHONDRIAL TRANSFER IN THE PATHOPHYSIOLOGY OF PREECLAMPSIA

  Illanes, S., J. Monteiro, L., Nardocci, G. & Acuña, S.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/24 → 31/03/28

  Project: Research

• FONDECYT REGULAR - 1240604: Brain astrocyte-derived extracellular vesicles orchestrate macrophage and microglia polarization under stress conditions through miRNA-dependent regulation of macrophage immunometabolism regulator (MACIR)

  Wyneken, Ú. (Principal Investigator), Pino-Lagos, K. (Co-Investigator) & Hidalgo, Y. (Co-Investigator)

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/24 → 31/03/28

  Project: Research

• FONDEF IDEA I+D 2023 - 23I10325: Desarrollo de un producto alogénico basado en un hidrogel bioactivo con nanovesículas extracelulares y su validación como tratamiento endodóntico regenerativo

  Cuenca, J. (Principal Investigator), Brizuela Cordero, C. (Alternate Director), Khoury, M. (Co-Investigator), Alcayaga-Miranda, F. (Co-Investigator), Canedo Marroquin, G. (Co-Investigator) & González-Arriagada, W. (Co-Investigator)

  National Agency for Research and Development (ANID)

  15/06/23 → 15/06/25

  Project: Research

• FONDECYT POSTDOCTORADO - 3230322: LA EXPRESIÓN DE HSP70 EN LA MEMBRANA DE VESÍCULAS EXTRACELULARES PREVIENEN EL DAÑO RENAL INDUCIDO POR ISQUEMIA/REPERFUSIÓN EN RATÓN.

  Irarrazabal Muñoz, C. E. & Soto, P.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  15/04/23 → 14/04/26

  Project: Research

• FONDECYT POSTDOCTORADO - 3230201: ROLE OF BASIGIN ON TROPHOBLAST INVASION REGULATED THROUGH EXTRACELULLAR VESICLES RELEASED FROM ENDOMETRIAL MESENCHYMAL STEM CELLS

  Illanes, S. & Peñailillo, R.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  15/04/23 → 14/04/26

  Project: Research

• FONDECYT POSTDOCTORADO - 3230447: TRASPLANTE DE MITOCONDRIAS RESISTENTES A LA HIPOXIA: UNA PROMETEDORA TERAPIA CONTRA LA HIPERTENSIÓN PULMONAR HIPÓXICA

  Cuenca, J. & Castillo, S.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  15/04/23 → 14/04/26

  Project: Research

• FONDECYT REGULAR - 1230932: THE POTENTIAL ROLE OF MENSTRUAL MESENCHYMAL STEM CELLS IN THE ETIOPATHOLOGY OF ENDOMETRIOSIS AND ITS ASSOCIATION WITH IMPAIRED ENDOMETRIUM RECEPTIVITY

  J. Monteiro, L., Donoso, M. B., Vega-Letter, A. M., Illanes, S. & Luz Crawford, P. A.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/23 → 31/03/27

  Project: Research

• FONDECYT REGULAR - 1230875:  REVEALING THE CONTRIBUTION OF MELANOMA-DERIVED CIRCULATING CELL-FREE MITOCHONDRIA IN THE FORMATION OF PREMETASTATIC NICHE IN LYMPH NODES AND THEIR IMPACT IN THE EARLY DEVELOPMENT OF METASTASIS

  Alcayaga-Miranda, F. (Principal Investigator), Khoury, M. (Co-Investigator), Pino-Lagos, K. (Co-Investigator), Hidalgo, Y. (Co-Investigator) & González-Arriagada, W. (Co-Investigator)

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/23 → 31/03/27

  Project: Research

• FONDECYT REGULAR - 1230645: PRODUCTION OF SALMON GELATIN BASED MICROGELS WITH DIFFERENT CROSSLINKING DENSITIES BY COMBINING SPRAY CONGEALING AND UV RADIATION.

  Enrione, J. I.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/23 → 31/03/26

  Project: Research

• FONDECYT INICIACIÓN - 11230101: BIOMARKERS IN DENTINAL FLUID AS NOVEL SIDE-DIAGNOSTIC FOR PULPITIS STAGES AND OF MINIMALLY INVASIVE VITAL PULP THERAPY

  Brizuela Cordero, C. (Principal Investigator)

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  15/03/23 → 14/03/26

  Project: Research

• FONDECYT POSTDOCTORADO - 3220289: ESTUDIO DE LA ESTRUCTURA INTERFACIAL DE EMULSIONES PICKERING O/W A PARTIR DE NANOCRISTALES DE CELULOSA DE PINO OBTENIDOS POR DIFERENTES PROCESOS DE HIDRÓLISIS.

  Díaz Calderón, P. C. & Alarcón, J.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  15/04/22 → 14/04/25

  Project: Research

• FONDECYT POSTDOCTORADO - 3220204: TRANSFERENCIA MITOCONDRIAL DESDE CÉLULAS MADRE MESENQUIMALES COMO UNA NUEVA ALTERNATIVA TERAPÉUTICA PARA DESÓRDENES DEL NEURODESARROLLO: RELEVANCIA EN EL RESCATE METABÓLICO Y FUNCIONAL DE CÉLULAS MADRE NEURALES

  Luz Crawford, P. A. & Bustamante, F. A.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  15/04/22 → 14/04/25

  Project: Research

• FONDECYT REGULAR – 1221099: UNDERSTANDING THE ROLE OF NANOCELLULOSE ON THE SELF-ASSOCIATION AND SELF-ASSEMBLING OF AMYLOSE-AMYLOPECTIN BASED COMPOSITES

  Díaz Calderón, P. C. & Quero, F.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/22 → 31/03/25

  Project: Research

• FONDECYT REGULAR - 1221376: UNCOVERING MECHANISMS CONTRIBUTING TO EXCENCEPHALY AND ITS PREVENTION BY MATERNAL VITAMIN E SUPPLEMENTATION IN HDL RECEPTOR SR-B1 KO MOUSE EMBRYOS

  Busso, D. (Principal Investigator)

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/22 → 31/03/26

  Project: Research

• FONDECYT INICIACIÓN - 11221070: DEVELOPMENT OF A BIOACTIVE RESIN COMPOSITE CONTAINING COPPER-DOPED BIOACTIVE GLASS NANOPARTICLES FOR THE PREVENTION OF SECONDARY CARIES

  Gutiérrez Reyes, M. (Principal Investigator)

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  15/03/22 → 14/03/25

  Project: Research

• FONDECYT INICIACIÓN - 11220601: EXPLORING THE CONTRIBUTION OF ASTROCYTE-DERIVED EXTRACELLULAR VESICLES TO CONTROL AXONAL PROTEIN SYNTHESIS BY MICRORNA TRANSFER

  Luarte Navarro, A. E.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  15/03/22 → 14/03/25

  Project: Research

• FONDECYT INICIACIÓN - 11220846: UNDERSTANDING THE COMPLEXATION AND AGGREGATION OF CHICKPEA PROTEINS AND CELLULOSE NANOCRYSTALS TOWARDS THE IMPROVEMENT OF PLANT-BASED PROTEIN DIGESTIBILITY

  Contardo, I. M.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  15/03/22 → 14/03/25

  Project: Research

• Center of Interventional Medicine for Precision and Advanced Cellular Therapy (IMPACT)

  Khoury, M. (Director), Alcayaga-Miranda, F. (Principal Investigator), Cuenca, J. (Principal Investigator), Acevedo, J. P. (Principal Investigator), Figueroa, F. (Principal Investigator), Luz Crawford, P. A. (Principal Investigator), Wyneken, Ú. (Principal Investigator), Illanes, S. (Principal Investigator), Batiz, L. F. (Associate Investigator), Busso, D. (Associate Investigator), J. Monteiro, L. (Associate Investigator), Nardocci, G. (Associate Investigator), Enrione, J. I. (Associate Investigator), Espinoza, F. (Associate Investigator), Valenzuela Bravo, M. T. (Associate Investigator) & Prieto, M. (Associate Investigator)

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/11/21 → 31/10/26

  Project: Research

• INVESTIGATING THE EFFECT OF MAVS ENRICHED MITOCHONDRIAL TRANSPLANTATION ON INTRACELLULAR ANTIVIRAL IMMUNITY AND THEIR RESTORATIVE AND IMMUNOMODULATORY EFFECTS IN A VIRALINDUCED ACUTE LUNG INJURY MODEL

  Cuenca, J., Alcayaga-Miranda, F., Khoury, M., Hidalgo, Y. & Kurte, M.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/21 → 31/03/25

  Project: Research

• FONDECYT REGULAR - 1211376: INVESTIGATING THE EFFECT OF MAVS-ENRICHED MITOCHONDRIAL TRANSPLANTATION ON INTRACELLULAR ANTIVIRAL IMMUNITY AND THEIR RESTORATIVE AND IMMUNOMODULATORY EFFECTS IN A VIRAL-INDUCED ACUTE LUNG INJURY MODEL.

  Cuenca, J., Alcayaga-Miranda, F., Khoury, M., Hidalgo, Y. & Kurte, M.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/21 → 31/03/25

  Project: Research

• FONDECYT REGULAR - 1211353: INVESTIGATING THE IMMUNOREGULATORY AND ANTI-RHEUMATOID ARTHRITIS ACTIVITIES OF SMALL EXTRACELLULAR VESICLES-SHUTTLED BIOACTIVE MICRORNA DERIVED FROM GLYCOLYTIC MESENCHYMAL STEM CELL

  Luz Crawford, P. A., Khoury, M., Alcayaga-Miranda, F., Elizondo-Vega, R., Altamirano, C. & Nova-Lamperti, E.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/21 → 31/03/25

  Project: Research

• FONDECYT REGULAR - 1211749: IMPACT OF HORIZONTAL ARTIFICIAL TRANSFER OF MITOCHONDRIA ON UMBILICAL CORD BLOOD TRANSPLANTATION AND ITS CLINICAL RELEVANCE IN GRAFT VERSUS HOST DISEASE.

  Khoury, M., Luz Crawford, P. A., Court, A. C. & Figueroa, F.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/21 → 31/03/25

  Project: Research

• FONDECYT REGULAR - 1210654: SMALL EXTRACELLULAR VESICLES OBTAINED FROM NEUROPILIN-1+ T REGULATORY CELLS AS A NOVEL TOOL FOR THE INDUCTION OF TRANSPLANTATION TOLERANCE

  Pino-Lagos, K. (Principal Investigator) & Wyneken, Ú. (Co-Investigator)

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/21 → 31/03/25

  Project: Research

• FONDECYT REGULAR - 1211471: THE PATHOGENIC VICIOUS CYCLE BETWEEN PERIODONTITIS AND GESTATIONAL DIABETES MELLITUS: COMMUNICATION VIA BACTERIAL TRANSLOCATION AND EXTRACELLULAR VESICLES

  Chaparro, A. (Principal Investigator), Busso, D. (Co-Investigator), Illanes, S. (Co-Investigator), Ramirez Lobos, V. (Co-Investigator), Hernández Ríos, E. (Co-Investigator) & Hoare, A. (Co-Investigator)

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/21 → 31/03/25

  Project: Research

• FONDECYT REGULAR - 1211384: PRENATAL STRESS: MATERNAL ASTROCYTE-DERIVED EXTRACELLULAR VESICLES AS A NOVEL STRESS-TRANSFER MECHANISM CONTRIBUTING TO ADVERSE OFFSPRING NEURODEVELOPMENT

  Batiz, L. F., Nardocci, G., Wyneken, Ú., Illanes, S., J. Monteiro, L. & Caradeux, J.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/21 → 31/03/25

  Project: Research

• Franco-Chilean initiative for Intra-Mitochondrial microRNAs as new mediators of mesenchymal stem cells immunoregulatory functions

  Luz Crawford, P. A.

  1/03/21 → 28/02/25

  Project: Research

• Efectos del laser de baja potencia en la proliferacion, viabilidad, morfologia y diferenciacion de celulas madre derivadas de encia.

  inostroza, C. (Principal Investigator), Matamala, F. (Co-Principal Investigator), Andrade, C. (Co-Investigator), Paredes, M. (Co-Investigator), Gutierrez, D. (Co-Investigator) & Ortiz, J. (Co-Investigator)

  4/09/17 → …

  Project: Research

• Millennium Institute on Immunology and Immunotherapy (IMII)

  Kalergis, A. M. (Principal Investigator) & Luz Crawford, P. A. (Co-Investigator)

  1/09/11 → 1/09/31

  Project: Research

  • Immunology 100%
  • Immunotherapy 100%
  • Antihormone Therapy 50%
  • Cellular Immunology 50%
  • Young Scientists 50%
• Not started

  FONDECYT POSTDOCTORADO - 3240135: Parches cardiacos multifuncionales basados en biomateriales electroconductores cargados con células madre mesenquimales

  Acevedo, J. P. & Olate, F.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  Project: Research

• FONDECYT POSTDOCTORADO - 3240476: Characterization and validation of early biomarkers of maternal supraphysiological hypercholesterolemia in maternal plasma from the first trimester of pregnancy

  Illanes, S. & Cantin, C.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  Project: Research

• Características funcionales y propiedades inmunomoduladoras de células madre mesenquimales de origen pulpar para el desarrollo de un modelo de regeneración tisular: Estudio experimental in vitro.

  inostroza, C. (Principal Investigator)

  Project: Research

• FONDECYT POSTDOCTORADO - 3240581: Exploring the effect of periodontitis-derived extracellular vesicles on microglial polarization and regulatory T cells neuroprotective function impairment in the brain. A possible link between Periodontitis and Neuroinflammation?

  Chaparro, A. (Sponsoring Researcher) & Rojas, C. (Postdoctoral Researcher)

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  Project: Research

• Finished

  Glycostem-sev: generación de un producto acelular basado en nanovesículas extracelulares derivadas de células madre mesenquimales inducidas hacia un metabolismo glicolítico para el tratamiento de la osteoartritis

  Luz Crawford, P. A., Alcayaga-Miranda, F., Elizondo-Vega, R. J., Espinoza, F. & Matas, J.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/11/21 → 30/11/23

  Project: Research

• Metabolic reprograming of effector CD4+T cells by mitochondrial mediated-signalling in oral cancer and its effect upon T helper and T-dependent B cell responses

  Nova, E. & Luz Crawford, P. A.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/03/21 → 29/02/24

  Project: Research

• Immunoregulatory and anti-rheumatoid arthritis activities of small extracellular vesicles-shuttled bioactive microRNA derived from glycolytic mesenchymal stem cells

  Luz Crawford, P. A.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/03/21 → 29/02/24

  Project: Research

• Validación socioproductiva de hidrogel algal como herramienta para el uso estratégico y eficiencte del agua en zonas afectadas por escasez hídrica

  Contardo, I. M.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/01/21 → 1/01/22

  Project: Research

• Fortalecimiento de la docencia e investigación en el diseño de matrices alimentarias para la mantención de masa muscular en adultos mayores

  Contardo, I. M.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/01/21 → 1/01/23

  Project: Research

• In vitro evaluation of Neuropilin-1+ extracellular vesicles derived from Foxp3+ T regulatory cells on CD4+ T effector cells phenotype and function

  Pino-Lagos, K. (Principal Investigator)

  Universidad de los Andes Chile

  7/09/20 → 7/09/21

  Project: Research

• The potential role of the inducible Oxide Nitric Synthase (iNOS) in accelerates renal regeneration after ischemia reperfusion injury

  Pasten, C.

  Universidad de los Andes Chile

  25/08/20 → 25/08/22

  Project: Research

• Generación de un extracto de un alimento andino con propiedades antidiabéticas

  Busso, D. (Principal Investigator), Enrione, J. I. (Principal Investigator) & Illanes, S. (Principal Investigator)

  1/08/20 → 30/11/20

  Project: Research

• Mirando al futuro: Efectos del estrés prenatal y perinatal asociado a la pandemia COVID-19 en el neurodesarrollo de niñas y niños de Chile

  Batiz, L. F., Illanes, S., J. Monteiro, L., Tenorio, M., Avaria, M. D. L. A., Nardocci, G., Nuñez, M. I. & Peñailillo, R.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  6/07/20 → 1/01/22

  Project: Research

• FONDECYT REGULAR - 1200693: Brain astrocyte-derived extracellular vesicles promote protective Treg induction in the GALT and restore gut tolerance in stressed rats

  Wyneken, Ú. (Principal Investigator), Batiz, L. F. (Co-Principal Investigator), Pino-Lagos, K. (Co-Investigator) & Batiz, L. F. (Co-Investigator)

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/20 → 31/03/24

  Project: Research

• FONDECYT REGULAR - 1201584: Understanding of shape memory properties of gelatin-cellulose nanocrystal composites through interaction assessments at their interface

  Enrione, J. I., Quero, F. & Melo, F.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/20 → 31/03/23

  Project: Research

• FONDECYT REGULAR - 1201420: Mitochondrial transfer within the osteoarthritic joint: restoration of the dysfunctional stress-response and metabolic pathway in cartilage in-vitro and in an animal model of disease

  Figueroa, F., Khoury, M., Luz Crawford, P. A. & Court, A. C.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/20 → 31/03/24

  Project: Research

• FONDECYT REGULAR - 1201851: Role of mesenchymal stem cells in implantation and their contribution to the decidualization disorders present in preeclampsia

  Illanes, S. (Principal Investigator), Pino-Lagos, K. (Co-Investigator), J. Monteiro, L. (Co-Investigator) & Acuña, S. (Co-Investigator)

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/04/20 → 31/03/23

  Project: Research

• Association between periodontal dysbiosis and immune evasion in gastric cancer

  Retamal, I. (Principal Investigator) & Chaparro, A. (Sponsoring Researcher)

  5/03/20 → 4/03/22

  Project: Research

• Mitochondrial transfer from mesenchymal stem cells for osteoarthritis treatment

  Figueroa, F. & Luz Crawford, P. A.

  Agencia Nacional de Investigación y Desarrollo (ANID), Chile

  1/03/20 → 28/02/23

  Project: Research

• Lipophilic statins inhibit the exosome-mediated and obesity-induced cancer progression: the relevance of reestablishing natural killer cell immune surveillance to delay recurrence and improve future therapeutic outcomes in high-grade serous ovarian cancer

  Cuello, M. (Principal Investigator) & Busso, D. (Co-Investigator)

  1/03/20 → 28/02/23

  Project: Research

• Desarrollo de modelo de procesamiento oral in-vitro de adultos mayores y su uso en el estudio de degradación de proteínas vegetales de rápida digestibilidad para promover la síntesis de proteínas musculares

  Contardo, I. M. & Enrione, J. I.

  Universidad de los Andes

  1/01/20 → 1/12/20

  Project: Research

• Validación de algoritmo multiparamétrico para la predicción temprana de Diabetes Gestacional mediante marcadores plasmáticos maternos

  Illanes, S., J. Monteiro, L., Correa, P. & Monckeberg, M.

  1/01/20 → 1/01/23

  Project: Research