Centro de Investigación e Innovación Biomédica

Active

VIU - VIU24P0014: THE PATHOGENIC VICIOUS CYCLE BETWEEN PERIODONTITIS AND GESTATIONAL DIABETES MELLITUS: COMMUNICATION VIA BACTERIAL TRANSLOCATION AND EXTRACELLULAR VESICLES

Bendek Viera, M. J. (Principal Investigator) & Chaparro, A. (Co-Investigator)

4/11/24 → …

Project: Research

FONDECYT REGULAR - 1241103: DECIPHERING THE ROLE OF MITOCHONDRIAL TRANSFER IN THE PATHOPHYSIOLOGY OF PREECLAMPSIA

Illanes, S. (Principal Investigator), J. Monteiro, L. (Co-Investigator), Nardocci, G. (Co-Investigator) & Acuña, S. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/24 → 31/03/28

Project: Research

FONDECYT REGULAR - 1240604: Brain astrocyte-derived extracellular vesicles orchestrate macrophage and microglia polarization under stress conditions through miRNA-dependent regulation of macrophage immunometabolism regulator (MACIR)

Wyneken, Ú. (Principal Investigator), Pino-Lagos, K. (Co-Investigator) & Hidalgo, Y. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/24 → 31/03/28

Project: Research

FAI UANDES-UFRO - UAN-UFRO-2024-02: GUÍA DE PRÁCTICA CLÍNICA PARA LA DETECCIÓN Y DIAGNÓSTICO DEL CÁNCER DE LA CAVIDAD ORAL

González-Arriagada, W. A. (Co-Principal Investigator), Zaror, C. (Co-Principal Investigator), Espinoza, G. E. (Co-Investigator), Figueiredo Deana, N. (Co-Investigator) & Ortuño Borroto, D. R. (Co-Investigator)

Universidad de los Andes Chile, Universidad de la Frontera

1/11/23 → 31/10/25

Project: Research

FONDEF IDEA I+D 2023 - 23I10325: Desarrollo de un producto alogénico basado en un hidrogel bioactivo con nanovesículas extracelulares y su validación como tratamiento endodóntico regenerativo

Cuenca, J. (Principal Investigator), Brizuela Cordero, C. I. (Alternate Director), Khoury, M. (Co-Investigator), Alcayaga-Miranda, F. (Co-Investigator), Canedo Marroquin, G. (Co-Investigator) & González-Arriagada, W. A. (Co-Investigator)

National Agency for Research and Development (ANID)

15/06/23 → 15/06/25

Project: Research

FONDECYT POSTDOCTORADO - 3230201: ROLE OF BASIGIN ON TROPHOBLAST INVASION REGULATED THROUGH EXTRACELULLAR VESICLES RELEASED FROM ENDOMETRIAL MESENCHYMAL STEM CELLS

Illanes, S. (Sponsoring Researcher) & Peñailillo, R. (Postdoctoral Researcher)

Agencia Nacional de Investigación y Desarrollo (ANID)

15/04/23 → 14/04/26

Project: Research

FONDECYT POSTDOCTORADO - 3230322: LA EXPRESIÓN DE HSP70 EN LA MEMBRANA DE VESÍCULAS EXTRACELULARES PREVIENEN EL DAÑO RENAL INDUCIDO POR ISQUEMIA/REPERFUSIÓN EN RATÓN.

Irarrazabal Muñoz, C. E. (Sponsoring Researcher) & Soto, P. (Postdoctoral Researcher)

Agencia Nacional de Investigación y Desarrollo (ANID)

15/04/23 → 14/04/26

Project: Research

FONDECYT POSTDOCTORADO - 3230447: TRASPLANTE DE MITOCONDRIAS RESISTENTES A LA HIPOXIA: UNA PROMETEDORA TERAPIA CONTRA LA HIPERTENSIÓN PULMONAR HIPÓXICA

Cuenca, J. (Sponsoring Researcher) & Castillo, S. (Postdoctoral Researcher)

Agencia Nacional de Investigación y Desarrollo (ANID)

15/04/23 → 14/04/26

Project: Research

FONDECYT REGULAR - 1230932: THE POTENTIAL ROLE OF MENSTRUAL MESENCHYMAL STEM CELLS IN THE ETIOPATHOLOGY OF ENDOMETRIOSIS AND ITS ASSOCIATION WITH IMPAIRED ENDOMETRIUM RECEPTIVITY

J. Monteiro, L. (Principal Investigator), Donoso, M. B. (Co-Investigator), Vega-Letter, A. M. (Co-Investigator), Illanes, S. (Co-Investigator) & Luz Crawford, P. A. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/23 → 31/03/27

Project: Research

FONDECYT REGULAR - 1230645: PRODUCTION OF SALMON GELATIN BASED MICROGELS WITH DIFFERENT CROSSLINKING DENSITIES BY COMBINING SPRAY CONGEALING AND UV RADIATION.

Enrione, J. I. (Principal Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/23 → 31/03/26

Project: Research

FONDECYT REGULAR - 1230875: REVEALING THE CONTRIBUTION OF MELANOMA-DERIVED CIRCULATING CELL-FREE MITOCHONDRIA IN THE FORMATION OF PREMETASTATIC NICHE IN LYMPH NODES AND THEIR IMPACT IN THE EARLY DEVELOPMENT OF METASTASIS

Alcayaga-Miranda, F. (Principal Investigator), Khoury, M. (Co-Investigator), Pino-Lagos, K. (Co-Investigator), Hidalgo, Y. (Co-Investigator) & González-Arriagada, W. A. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/23 → 31/03/27

Project: Research

FONDECYT INICIACIÓN - 11230101: BIOMARKERS IN DENTINAL FLUID AS NOVEL SIDE-DIAGNOSTIC FOR PULPITIS STAGES AND OF MINIMALLY INVASIVE VITAL PULP THERAPY

Brizuela Cordero, C. I. (Principal Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

15/03/23 → 14/03/26

Project: Research

FONDECYT REGULAR - 1221376: UNCOVERING MECHANISMS CONTRIBUTING TO EXCENCEPHALY AND ITS PREVENTION BY MATERNAL VITAMIN E SUPPLEMENTATION IN HDL RECEPTOR SR-B1 KO MOUSE EMBRYOS

Busso, D. (Principal Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/22 → 31/03/26

Project: Research

CONTRATOS TECNOLOGICOS - 21CVC2-183649: BIOADHESIVO DE CAPAS DELGADAS Y LIBERACIÓN TRIFÁSICA CONTROLADA DE ANTIMICROBIANOS PARA SALUD BUCAL

Haidar, Z. S. (Principal Investigator)

16/11/21 → …

Project: Research

IMPACT: CENTER OF INTERVENTIONAL MEDICINE FOR PRECISION AND ADVANCED CELLULAR THERAPY

Khoury, M. (Director), Alcayaga-Miranda, F. (Principal Investigator), Cuenca, J. (Principal Investigator), Acevedo, J. P. (Principal Investigator), Figueroa, F. (Principal Investigator), Luz Crawford, P. A. (Principal Investigator), Wyneken, Ú. (Principal Investigator), Illanes, S. (Principal Investigator), Batiz, L. F. (Associate Investigator), Busso, D. (Associate Investigator), J. Monteiro, L. (Associate Investigator), Nardocci, G. (Associate Investigator), Enrione, J. I. (Associate Investigator), Espinoza, F. (Associate Investigator), Valenzuela Bravo, M. T. (Associate Investigator) & Prieto, M. (Associate Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/11/21 → 31/10/26

Project: Research

Efectos del laser de baja potencia en la proliferacion, viabilidad, morfologia y diferenciacion de celulas madre derivadas de encia.

Inostroza, C. (Principal Investigator), Matamala, F. (Co-Principal Investigator), Andrade, C. (Co-Investigator), Paredes, M. (Co-Investigator), Gutierrez, D. (Co-Investigator) & Ortiz, J. (Co-Investigator)

4/09/17 → …

Project: Research

Millennium Institute on Immunology and Immunotherapy (IMII)

Kalergis, A. M. (Principal Investigator) & Luz Crawford, P. A. (Co-Investigator)

1/09/11 → 1/09/31

Project: Research

Not started

CONTRATOS TECNOLOGICOS - 22CVC2-218196: ENDOCOAT'X: NANOCUBIERTA POLIMÉRICA MULTICAPAS PARA LIMAS DE NITINOL, CON PROPIEDADES ANTIMICROBIANAS PARA SU LIBERACIÓN DURANTE EL TRATAMIENTO ENDODÓNTICO

Haidar, Z. S. (Principal Investigator)

Project: Research

Características funcionales y propiedades inmunomoduladoras de células madre mesenquimales de origen pulpar para el desarrollo de un modelo de regeneración tisular: Estudio experimental in vitro.

Inostroza, C. (Principal Investigator)

Project: Research

FONDECYT POSTDOCTORADO - 3240476: Characterization and validation of early biomarkers of maternal supraphysiological hypercholesterolemia in maternal plasma from the first trimester of pregnancy

Illanes, S. (Sponsoring Researcher) & Cantin, C. (Postdoctoral Researcher)

Agencia Nacional de Investigación y Desarrollo (ANID)

Project: Research

FONDECYT POSTDOCTORADO - 3240135: Parches cardiacos multifuncionales basados en biomateriales electroconductores cargados con células madre mesenquimales

Acevedo, J. P. (Sponsoring Researcher) & Olate, F. (Postdoctoral Researcher)

Agencia Nacional de Investigación y Desarrollo (ANID)

Project: Research

CONTRATOS TECNOLOGICOS - 21CVC2-183591: PINTURA ANTI-FOULING A BASE DE NANOCU EN UN NANO-COMPUESTO DE ZNO/GO PARA DE REDES DE CULTIVO

Haidar, Z. S. (Principal Investigator)

Project: Research

FONDECYT POSTDOCTORADO - 3240581: Exploring the effect of periodontitis-derived extracellular vesicles on microglial polarization and regulatory T cells neuroprotective function impairment in the brain. A possible link between Periodontitis and Neuroinflammation?

Chaparro, A. (Sponsoring Researcher) & Rojas, C. (Postdoctoral Researcher)

Agencia Nacional de Investigación y Desarrollo (ANID)

Project: Research

DESAFIOS PUBLICOS - RP24I40001: IMPLEMENTACIÓN DE UN SISTEMA RÁPIDO DE DETECCIÓN DE HORMONAS SEXUALES EN SANGRE HUMANA INSTAXYBLOODT EN CRÍMENES CON ARMAS DE FUEGO

Inostroza, C. (Principal Investigator)

Project: Research

Finished

FAI ATP MICARE - INV-ATP MICARE-2023-01: IMPACTO DE UN PROGRAMA DE EDUCACIÓN EN SALUD ORAL DIRIGIDO A CUIDADORES DE PERSONAS MAYORES CON DISTINTOS GRADOS DE DETERIORO COGNITIVO EN EL CONTROL DEL BIOFILM DENTAL

Prieto Damm, D. J. (Principal Investigator) & Chaparro, A. (Co-Investigator)

Universidad de los Andes Chile

1/10/23 → 1/10/24

Project: Research

FAI INSCRIPCION CONGRESO - APO-CG-2023-31: A 6-MONTH CLINICAL EVALUATION OF PROLONGED SOLVENT EVAPORATION TIME OF TWO UNIVERSAL ADHESIVE IN NON-CARIOUS CERVICAL LESIONS: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL

Gutiérrez Reyes, M. F. (Principal Investigator)

Universidad de los Andes Chile

4/09/23 → 30/12/23

Project: Research

FAI INSCRIPCION CONGRESO - APO-CG-2023-28: INCREASED GINGIVAL CREVICULAR FLUID EXTRACELLULAR VESICLES ARE INVOLVED IN THE CROSSTALK BETWEEN PERIODONTITIS AND GESTATIONAL DIABETES

Mizgier, M. L. (Principal Investigator), Realini, O. (Co-Investigator), Bendek Viera, M. J. (Co-Investigator), Rojas Pérez, C. I. (Co-Investigator), Monje, S. (Co-Investigator), Figari, A. (Co-Investigator), Hernández, M. (Co-Investigator), Ramírez Lobos, V. (Co-Investigator), Illanes, S. (Co-Investigator), Busso, D. (Co-Investigator) & Chaparro, A. (Co-Investigator)

Universidad de los Andes Chile

4/09/23 → 30/12/23

Project: Research

FAI ORGANIZACIÓN CONGRESO - APO-OR-2023-03: PERIODONTAL DISEASE AND SYSTEMIC HEALTH: THE PERIO-INFLAMMATION SYMPOSIUM

Chaparro, A. (Principal Investigator)

Universidad de los Andes Chile

1/07/23 → 28/02/24

Project: Research

FONDEF 1RA ETAPA - ID22I10215: PREVENTING HYPOSALIVATION AND SALIVARY GLAND DYSFUNCTION FOLLOWING Γ-IRRADIATION OF THE HEAD AND NECK USING INJECTABLE AND RELEASE-TUNABLE NANO-SIZED DUAL-DRUG DELIVERY SYSTEM: PRE-CLINICAL SAFETY AND EFFICACY VALIDATION; A STEP CLOSER TO THE CLINIC

Haidar, Z. S. (Principal Investigator) & Bravo, C. (Co-Investigator)

14/10/22 → 16/10/24

Project: Research

CONTRATOS TECNOLOGICOS - 22CVID-206879: SCREENING ORAL PARA LA PREDICCIÓN TEMPRANA DE DIABETES GESTACIONAL

Chaparro, A. (Principal Investigator), Illanes, S. (Co-Investigator) & Nardocci, G. (Co-Investigator)

1/09/22 → 26/10/24

Project: Research

FAI INSCRIPCION CONGRESO - APO-CG-2022-03: SOCKGEL/PLUG: INJECTABLE NANO-SCALED HYDROGEL PLATFORMS FOR ORAL AND MAXILLOFACIAL INTERVENTIONAL APPLICATION

Haidar, Z. S. (Principal Investigator)

Universidad de los Andes Chile

1/08/22 → 30/09/22

Project: Research

FONDECYT POSTDOCTORADO - 3220204: TRANSFERENCIA MITOCONDRIAL DESDE CÉLULAS MADRE MESENQUIMALES COMO UNA NUEVA ALTERNATIVA TERAPÉUTICA PARA DESÓRDENES DEL NEURODESARROLLO: RELEVANCIA EN EL RESCATE METABÓLICO Y FUNCIONAL DE CÉLULAS MADRE NEURALES

Luz Crawford, P. A. (Sponsoring Researcher) & Bustamante, F. A. (Postdoctoral Researcher)

Agencia Nacional de Investigación y Desarrollo (ANID)

15/04/22 → 14/04/25

Project: Research

FONDECYT POSTDOCTORADO - 3220289: ESTUDIO DE LA ESTRUCTURA INTERFACIAL DE EMULSIONES PICKERING O/W A PARTIR DE NANOCRISTALES DE CELULOSA DE PINO OBTENIDOS POR DIFERENTES PROCESOS DE HIDRÓLISIS.

Díaz Calderón, P. C. (Sponsoring Researcher) & Alarcón, J. (Postdoctoral Researcher)

Agencia Nacional de Investigación y Desarrollo (ANID)

15/04/22 → 14/04/25

Project: Research

FONDECYT REGULAR – 1221099: UNDERSTANDING THE ROLE OF NANOCELLULOSE ON THE SELF-ASSOCIATION AND SELF-ASSEMBLING OF AMYLOSE-AMYLOPECTIN BASED COMPOSITES

Díaz Calderón, P. C. (Principal Investigator) & Quero, F. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/22 → 31/03/25

Project: Research

FONDECYT INICIACIÓN - 11221070: DEVELOPMENT OF A BIOACTIVE RESIN COMPOSITE CONTAINING COPPER-DOPED BIOACTIVE GLASS NANOPARTICLES FOR THE PREVENTION OF SECONDARY CARIES

Gutiérrez Reyes, M. F. (Principal Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

15/03/22 → 14/03/25

Project: Research

FONDECYT INICIACIÓN - 11220601: EXPLORING THE CONTRIBUTION OF ASTROCYTE-DERIVED EXTRACELLULAR VESICLES TO CONTROL AXONAL PROTEIN SYNTHESIS BY MICRORNA TRANSFER

Luarte Navarro, A. E. (Principal Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

15/03/22 → 14/03/25

Project: Research

FONDECYT INICIACIÓN - 11220846: UNDERSTANDING THE COMPLEXATION AND AGGREGATION OF CHICKPEA PROTEINS AND CELLULOSE NANOCRYSTALS TOWARDS THE IMPROVEMENT OF PLANT-BASED PROTEIN DIGESTIBILITY

Contardo, I. M. (Principal Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

15/03/22 → 14/03/25

Project: Research

Glycostem-sev: generación de un producto acelular basado en nanovesículas extracelulares derivadas de células madre mesenquimales inducidas hacia un metabolismo glicolítico para el tratamiento de la osteoartritis

Luz Crawford, P. A. (Principal Investigator), Alcayaga-Miranda, F. (Co-Investigator), Elizondo-Vega, R. J. (Co-Investigator), Espinoza, F. (Co-Investigator) & Matas, J. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/11/21 → 30/11/23

Project: Research

NAM - NAM21I0022: VALIDATING A SUTURE- AND DRUG-FREE HYDROGEL AS AN INJECTABLE ORAL DRESSING FOR PAINLESS PROMOTION OF DENTAL EXTRACTION SOCKET HEALING AND PREVENTION OF ALVEOLAR OSTEITIS IN THE FRAIL AND/OR INSTITUTIONALIZED AGEING ADULT

Haidar, Z. S. (Principal Investigator)

12/10/21 → 12/12/22

Project: Research

FONDECYT REGULAR - 1211353: INVESTIGATING THE IMMUNOREGULATORY AND ANTI-RHEUMATOID ARTHRITIS ACTIVITIES OF SMALL EXTRACELLULAR VESICLES-SHUTTLED BIOACTIVE MICRORNA DERIVED FROM GLYCOLYTIC MESENCHYMAL STEM CELL

Luz Crawford, P. A. (Principal Investigator), Khoury, M. (Co-Investigator), Alcayaga-Miranda, F. (Co-Investigator), Elizondo-Vega, R. (Co-Investigator), Altamirano, C. (Co-Investigator) & Nova-Lamperti, E. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/21 → 31/03/25

Project: Research

FONDECYT REGULAR - 1211749: IMPACT OF HORIZONTAL ARTIFICIAL TRANSFER OF MITOCHONDRIA ON UMBILICAL CORD BLOOD TRANSPLANTATION AND ITS CLINICAL RELEVANCE IN GRAFT VERSUS HOST DISEASE.

Khoury, M. (Principal Investigator), Luz Crawford, P. A. (Co-Investigator), Court, A. C. (Co-Investigator) & Figueroa, F. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/21 → 31/03/25

Project: Research

FONDECYT REGULAR - 1211384: PRENATAL STRESS: MATERNAL ASTROCYTE-DERIVED EXTRACELLULAR VESICLES AS A NOVEL STRESS-TRANSFER MECHANISM CONTRIBUTING TO ADVERSE OFFSPRING NEURODEVELOPMENT

Batiz, L. F. (Principal Investigator), Nardocci, G. (Co-Investigator), Wyneken, Ú. (Co-Investigator), Illanes, S. (Co-Investigator), J. Monteiro, L. (Co-Investigator) & Caradeux, J. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/21 → 31/03/25

Project: Research

FONDECYT REGULAR - 1211471: THE PATHOGENIC VICIOUS CYCLE BETWEEN PERIODONTITIS AND GESTATIONAL DIABETES MELLITUS: COMMUNICATION VIA BACTERIAL TRANSLOCATION AND EXTRACELLULAR VESICLES

Chaparro, A. (Principal Investigator), Busso, D. (Co-Investigator), Illanes, S. (Co-Investigator), Ramirez Lobos, V. (Co-Investigator), Hernández Ríos, E. (Co-Investigator) & Hoare, A. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/21 → 31/03/25

Project: Research

FONDECYT REGULAR - 1210654: SMALL EXTRACELLULAR VESICLES OBTAINED FROM NEUROPILIN-1+ T REGULATORY CELLS AS A NOVEL TOOL FOR THE INDUCTION OF TRANSPLANTATION TOLERANCE

Pino-Lagos, K. (Principal Investigator) & Wyneken, Ú. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/21 → 31/03/25

Project: Research

FONDECYT REGULAR - 1211376: INVESTIGATING THE EFFECT OF MAVS-ENRICHED MITOCHONDRIAL TRANSPLANTATION ON INTRACELLULAR ANTIVIRAL IMMUNITY AND THEIR RESTORATIVE AND IMMUNOMODULATORY EFFECTS IN A VIRAL-INDUCED ACUTE LUNG INJURY MODEL.

Cuenca, J. (Principal Investigator), Alcayaga-Miranda, F. (Co-Investigator), Khoury, M. (Co-Investigator), Hidalgo, Y. (Co-Investigator) & Kurte, M. (Principal Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/21 → 31/03/25

Project: Research

INVESTIGATING THE EFFECT OF MAVS ENRICHED MITOCHONDRIAL TRANSPLANTATION ON INTRACELLULAR ANTIVIRAL IMMUNITY AND THEIR RESTORATIVE AND IMMUNOMODULATORY EFFECTS IN A VIRALINDUCED ACUTE LUNG INJURY MODEL

Cuenca, J. (Principal Investigator), Alcayaga-Miranda, F. (Co-Investigator), Khoury, M. (Co-Investigator), Hidalgo, Y. (Co-Investigator) & Kurte, M. (Co-Investigator)

Agencia Nacional de Investigación y Desarrollo (ANID)

1/04/21 → 31/03/25

Project: Research