Research output per year
Research output per year
- 1 - 50 out of 133 results
Search results
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2025
Unraveling the pathogenesis of viral-induced pulmonary arterial hypertension: Possible new therapeutic avenues with mesenchymal stromal cells and their derivatives.
Castillo-Galán, S., Parra, V. & Cuenca, J., Jan 2025, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1871, 1, 167519.Research output: Contribution to journal › Review article › peer-review
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2024
A Phase I Dose-Escalation Clinical Trial to Assess the Safety and Efficacy of Umbilical Cord-Derived Mesenchymal Stromal Cells in Knee Osteoarthritis
Matas, J., García, C., Poblete, D., Vernal, R., Ortloff, A., Luque-Campos, N., Hidalgo, Y., Cuenca, J., Infante, C., Cadiz, M. I., Khoury, M., Luz-Crawford, P. & Espinoza, F., Mar 2024, In: Stem cells translational medicine. 13, 3, p. 193-203 11 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Efficacy of a single dose of cryopreserved human umbilical cord mesenchymal stromal cells for the treatment of knee osteoarthritis:a randomized, controlled, double-blind pilot study
Pico, O. A., Espinoza, F., Cádiz, M. I., Sossa, C. L., Becerra-Bayona, S. M., Salgado, M. C. C., Rodríguez, J. E. R., Cárdenas, O. F. V., Cure, J. M. Q., Khoury, M. & Arango-Rodríguez, M. L., 2024, (Accepted/In press) In: Cytotherapy.Research output: Contribution to journal › Article › peer-review
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Impact of platelet-derived mitochondria transfer in the metabolic profiling and progression of metastatic MDA-MB-231 human triple-negative breast cancer cells
Cereceda, L., Cardenas, J. C., Khoury, M., Silva-Pavez, E. & Hidalgo, Y., 14 Jan 2024, In: Frontiers in Cell and Developmental Biology. 11, p. 1-14 14 p., 1324158.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Levels of Small Extracellular Vesicles Containing hERG-1 and Hsp47 as Potential Biomarkers for Cardiovascular Diseases
Osorio, L. A., Lozano, M., Soto, P., Moreno-Hidalgo, V., Arévalo-Gil, A., Ramírez-Balaguera, A., Hevia, D., Cifuentes, J., Hidalgo, Y., Alcayaga-Miranda, F., Pasten, C., Morales, D., Varela, D., Urquidi, C., Iturriaga, A., Rivera-Palma, A., Larrea-Gómez, R. & Irarrázabal, C. E., May 2024, In: International Journal of Molecular Sciences. 25, 9, 4913.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitochondrial transfer balances cell redox, energy and metabolic homeostasis in the osteoarthritic chondrocyte preserving cartilage integrity
Court, A. C., Vega-Letter, A. M., Parra-Crisóstomo, E., Velarde, F., García, C., Ortloff, A., Vernal, R., Pradenas, C., Luz-Crawford, P., Khoury, M. & Figueroa, F. E., 2024, In: Theranostics. 14, 17, p. 6471-6486 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Survival advantage of native and engineered T cells is acquired by mitochondrial transfer from mesenchymal stem cells
Court, A. C., Parra-Crisóstomo, E., Castro-Córdova, P., Abdo, L., Aragão, E. A. A., Lorca, R., Figueroa, F. E., Bonamino, M. H. & Khoury, M., Dec 2024, In: Journal of Translational Medicine. 22, 1, 868.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
An advanced biphasic porous and injectable scaffold displays a fine balance between mechanical strength and remodeling capabilities essential for cartilage regeneration
Zavala, G., Viafara-García, S. M., Novoa, J., Hidalgo, C., Contardo, I., Díaz-Calderón, P., Alejandro González-Arriagada, W., Khoury, M. & Acevedo, J. P., 25 Aug 2023, In: Biomaterials Science. 11, 20, p. 6801-6822 22 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
A novel porous hydrogel based on hybrid gelation for injectable and tough scaffold implantation and tissue engineering applications
Hidalgo, C., Méndez-Ruette, M., Zavala, G., Viafara-García, S., Novoa, J., Díaz-Calderón, P., González-Arriagada, W. A., Cuenca, J., Khoury, M. & Acevedo Cox, J. P., 24 May 2023, In: Biomedical Materials (Bristol). 18, 4, 045014.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Business advisory services and innovation during crises: Evidence from small businesses in Chile
Acevedo, J., Diaz-Molina, I., Johan, S. & Valenzuela, P., Nov 2023, In: Journal of Business Research.Research output: Contribution to journal › Article › peer-review
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Oral Administration as a Potential Alternative for the Delivery of Small Extracellular Vesicles
Donoso-Meneses, D., Figueroa-Valdés, A. I., Khoury, M. & Alcayaga-Miranda, F., 21 Feb 2023, In: Pharmaceutics. 15, 3, p. 716 716.Research output: Contribution to journal › Review article › peer-review
Open Access14 Scopus citations -
Safety and efficacy of clinical-grade, cryopreserved menstrual blood mesenchymal stromal cells in experimental acute respiratory distress syndrome
Alcayaga-Miranda, F., Dutra Silva, J., Parada, N., Andrade da Silva, L. H., Ferreira Cruz, F., Utreras, Y., Hidalgo, Y., Cádiz, M. I., Tapia Limonchi, R., Espinoza, F., Bruhn, A., Khoury, M., R. M. Rocco, P. & Cuenca, J., 30 Jan 2023, In: Frontiers in Cell and Developmental Biology. 11, p. 1031331 1031331.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Turning adversity into opportunity: Small extracellular vesicles as nanocarriers for tumor-associated macrophages re-education
Donoso-Meneses, D., Figueroa-Valdés, A. I., Georges, N., Tobar, H. E. & Alcayaga-Miranda, F., Jan 2023, In: Bioengineering and Translational Medicine. 8, 1, e10349.Research output: Contribution to journal › Review article › peer-review
Open Access5 Scopus citations -
2022
An International Society for Cell and Gene Therapy Mesenchymal Stromal Cells Committee editorial on overcoming limitations in clinical trials of mesenchymal stromal cell therapy for coronavirus disease-19: time for a global registry
Weiss, D. J., Filiano, A., Galipeau, J., Khoury, M., Krampera, M., Lalu, M., Blanc, K. L., Nolta, J., Phinney, D. G., Rocco, P. R. M., Shi, Y., Tarte, K., Viswanathan, S. & Martin, I., Nov 2022, In: Cytotherapy. 24, 11, p. 1071-1073 3 p.Research output: Contribution to journal › Editorial
Open Access7 Scopus citations -
A Psychrophilic GelMA: Breaking Technical and Immunological Barriers for Multimaterial High-Resolution 3D Bioprinting
Zaupa, A., Terraza, C., Abarzúa-Illanes, P. N., Byres, N., Zavala, G., Cuenca, J., Hidalgo, C., Viafara-Garcia, S. M., Wolf, B., Pino-Lagos, K., Blaker, J. J., Rumbak, M., Khoury, M., Enrione, J. & Acevedo, J. P., 2022, In: Biomacromolecules. 24, 1, p. 150-165 16 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
CD49b Targeting Inhibits Tumor Growth and Boosts Anti-tumor Immunity
Contreras-Kallens, P., Gálvez-Jirón, F., De Solminihac, J., Elhusseiny, A., González-Arriagada, W. A., Alcayaga-Miranda, F., Noelle, R. J. & Pino-Lagos, K., 4 Jul 2022, In: Frontiers in Oncology. 12, p. 1-14 14 p., 928498.Research output: Contribution to journal › Article › peer-review
Open Access -
Delivery of affordable and scalable encapsulated allogenic/autologous mesenchymal stem cells in coagulated platelet poor plasma for dental pulp regeneration
Angelopoulos, I., Trigo, C., Ortuzar, M. I., Cuenca, J., Brizuela, C. & Khoury, M., Dec 2022, In: Scientific Reports. 12, 1, p. 1-15 15 p., 435.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Mesenchymal stem cell-mediated transfer of mitochondria: mechanisms and functional impact
Velarde, F., Ezquerra, S., Delbruyere, X., Caicedo, A., Hidalgo, Y. & Khoury, M., Mar 2022, In: Cellular and Molecular Life Sciences. 79, 3, 177.Research output: Contribution to journal › Review article › peer-review
41 Scopus citations -
The Four Pillars for Successful Regenerative Therapy in Endodontics: Stem Cells, Biomaterials, Growth Factors, and Their Synergistic Interactions
Brizuela, C., Huang, G. T. J., Diogenes, A., Botero, T. & Khoury, M., 19 Sep 2022, In: Stem Cells International. 2022, p. 1-17 17 p., 1580842.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2021
A Chemically Defined, Xeno- and Blood-Free Culture Medium Sustains Increased Production of Small Extracellular Vesicles From Mesenchymal Stem Cells
Figueroa-Valdés, A. I., de la Fuente, C., Hidalgo, Y., Vega-Letter, A. M., Tapia-Limonchi, R., Khoury, M. & Alcayaga Miranda, F., 26 May 2021, In: Frontiers in Bioengineering and Biotechnology. 9, p. 619930 619930.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Camouflage strategies for therapeutic exosomes evasion from phagocytosis
Parada, N., Romero-Trujillo, A., Georges, N. & Alcayaga Miranda, F., 1 Jul 2021, In: Journal of Advanced Research. 31, p. 61-74 14 p.Research output: Contribution to journal › Article › peer-review
Open Access120 Scopus citations -
Editorial: The Role of Metabolism in MSC-Mediated Immunomodulation
Pers, Y. M., Jorgensen, C. & Khoury, M., 26 Aug 2021, In: Frontiers in Immunology. 12, 751865.Research output: Contribution to journal › Editorial
Open Access4 Scopus citations -
Mitochondrial MicroRNAs Contribute to Macrophage Immune Functions Including Differentiation, Polarization, and Activation
Duroux-Richard, I., Apparailly, F. & Khoury, M., 3 Nov 2021, In: Frontiers in Physiology. 12, p. 738140 738140.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Mitochondria-Rich Fraction Isolated From Mesenchymal Stromal Cells Reduces Lung and Distal Organ Injury in Experimental Sepsis∗
De Carvalho, L. R. P., Abreu, S. C., De Castro, L. L., Andrade Da Silva, L. H., Silva, P. M., Vieira, J. B., Santos, R. T., Cabral, M. R., Khoury, M., Weiss, D. J., Lopes-Pacheco, M., Silva, P. L., Cruz, F. F. & Rocco, P. R. M. E., Sep 2021, In: Critical Care Medicine. 49, 9, p. E880-E890Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Musculoskeletal Progenitor/Stromal Cell-Derived Mitochondria Modulate Cell Differentiation and Therapeutical Function
Jorgensen, C. & Khoury, M., 8 Mar 2021, In: Frontiers in Immunology. 12, p. 606781 606781.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential
Contreras-Lopez, R., Elizondo-Vega, R., Luque-Campos, N., Torres, M. J., Pradenas, C., Tejedor, G., Paredes-Martínez, M. J., Vega-Letter, A. M., Campos-Mora, M., Rigual-Gonzalez, Y., Oyarce, K., Salgado, M., Jorgensen, C., Khoury, M., Garcia-Robles, M. D. L. Á., Altamirano, C., Djouad, F. & Luz-Crawford, P., 2021, In: Theranostics. 11, 1, p. 445-460 16 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
2020
Allogeneic Cellular Therapy in a Mature Tooth with Apical Periodontitis and Accidental Root Perforation: A Case Report
Cordero, C. B., Santander, G. M., González, D. U., Quezada, A., Silva, C. I., Vásquez, C., Jara, R., Jara, D. & Khoury, M., Dec 2020, In: Journal of Endodontics. 46, 12, p. 1920-1927.e1 9 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Cell-Based Regenerative Endodontics for Treatment of Periapical Lesions: A Randomized, Controlled Phase I/II Clinical Trial
Brizuela, C., Meza, G., Urrejola, D., Quezada, M. A., Concha, G., Ramírez, V., Angelopoulos, I., Cadiz, M. I., Tapia-Limonchi, R. & Khoury, M., 1 May 2020, In: Journal of Dental Research. 99, 5, p. 523-529 7 p.Research output: Contribution to journal › Article › peer-review
85 Scopus citations -
Cell-based therapies for coronavirus disease 2019: proper clinical investigations are essential
Khoury, M., Rocco, P. R. M., Phinney, D. G., Krampera, M., Martin, I., Viswanathan, S., Nolta, J. A., LeBlanc, K., Galipeau, J. & Weiss, D. J., Nov 2020, In: Cytotherapy. 22, 11, p. 602-605 4 p.Research output: Contribution to journal › Review article › peer-review
Open Access31 Scopus citations -
Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19
Khoury, M., Cuenca, J., Cruz, F. F., Figueroa, F. E., Rocco, P. R. M. & Weiss, D. J., 1 Jun 2020, In: European Respiratory Journal. 55, 6, 2000858.Research output: Contribution to journal › Review article › peer-review
Open Access196 Scopus citations -
Generation of Functional Stem Cell-Derived CD105neg CD73low Melanocyte Precursors Guided by Defined Culture Conditions
Zavala, G., Sandoval, C., Meza, D., Contreras, R., Gubelin, W. & Khoury, M., 24 Mar 2020, In: SSRN Electronic Journal.Research output: Contribution to journal › Article › peer-review
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HIF1α-dependent metabolic reprogramming governs mesenchymal stem/stromal cell immunoregulatory functions
Contreras-Lopez, R., Elizondo-Vega, R., Paredes, M. J., Luque-Campos, N., Torres, M. J., Tejedor, G., Vega-Letter, A. M., Figueroa-Valdés, A., Pradenas, C., Oyarce, K., Jorgensen, C., Khoury, M., Garcia-Robles, M. D. L. A., Altamirano, C., Djouad, F. & Luz Crawford, P. A., 1 Jun 2020, In: FASEB Journal. 34, 6, p. 8250-8264 15 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
Magic realism: a Latin American paradigm for stem cell research & development?
Khoury, M. & Figueroa, F. E., 1 Feb 2020, In: Gene Therapy. 27, 1-2, p. 2-5 4 p.Research output: Contribution to journal › Comment/debate
1 Scopus citations -
Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response
Court, A. C., Le-Gatt, A., Luz-Crawford, P., Parra, E., Aliaga-Tobar, V., Bátiz, L. F., Contreras, R. A., Ortúzar, M. I., Kurte, M., Elizondo-Vega, R., Maracaja-Coutinho, V., Pino-Lagos, K., Figueroa, F. E. & Khoury, M., 5 Feb 2020, In: EMBO Reports. 21, 2, e48052.Research output: Contribution to journal › Article › peer-review
Open Access158 Scopus citations -
PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties
Contreras-Lopez, R. A., Elizondo-Vega, R., Torres, M. J., Vega-Letter, A. M., Luque-Campos, N., Paredes-Martinez, M. J., Pradenas, C., Tejedor, G., Oyarce, K., Salgado, M., Jorgensen, C., Khoury, M., Kronke, G., Garcia-Robles, M. A., Altamirano, C., Luz Crawford, P. A. & Djouad, F., 1 Dec 2020, In: Scientific Reports. 10, 1, 11423.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Semipermeable Cellulose Beads Allow Selective and Continuous Release of Small Extracellular Vesicles (sEV) From Encapsulated Cells
Zavala, G., Ramos, M. P., Figueroa-Valdés, A. I., Cisternas, P., Wyneken, U., Hernández, M., Toa, P., Salmons, B., Dangerfield, J., Gunzburg, W. H. & Khoury, M., 21 May 2020, In: Frontiers in Pharmacology. 11, 679.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Single cell migration profiling on a microenvironmentally tunable hydrogel microstructure device that enables stem cell potency evaluation
Ros, E., Encina, M., González, F., Contreras, R., Luz-Crawford, P., Khoury, M. & Acevedo, J. P., 7 Mar 2020, In: Lab on a Chip. 20, 5, p. 958-972 15 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
The Coronavirus Pandemic: A Pitfall or a Fast Track for Validating Cell Therapy Products?
Khoury, M., Ikonomou, L., Dominici, M., Le Blanc, K., Levine, B. L. & Weiss, D. J., 14 Dec 2020, In: Stem Cells and Development. 30, 3, p. 119-127 9 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Time-dependent LPS exposure commands MSC immunoplasticity through TLR4 activation leading to opposite therapeutic outcome in EAE.
Kurte, M., Vega-Letter, A. M., Luz Crawford, P. A., Djouad, F., Noël, D., Khoury, M. & Carrión, F., 25 Sep 2020, In: Stem Cell Research and Therapy. 11, 1, 416.Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
2019
Adipose tissue-derived mesenchymal stromal cells in patients with chronic kidney disease: A pilot study assessing safety and clinical feasibility
Villanueva, S., González, F., Lorca, E., Tapia, A., Valentina López, G., Strodthoff, R., Fajre, F., Carreño, J. E., Valjalo, R., Vergara, C., Lecanda, M., Bartolucci, J., Figueroa, F. E. & Khoury, M., 2019, In: Kidney Research and Clinical Practice. 38, 2, p. 176-185 10 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Angiogenic properties of menstrual stem cells are impaired in women with a history of preeclampsia
Varas-Godoy, M., Acuña-Gallardo, S., Venegas-Duarte, S., Hill, C., Caceres-Verschae, A., Realini, O., Monteiro, L., Zavala, G., Khoury, M., Romero, R., Rice, G. & Illanes, S., 2019, In: Stem Cells International. 2019, 1916542.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Author Correction: Rapid fabrication of reinforced and cell-laden vascular grafts structurally inspired by human coronary arteries (Nature Communications, (2019), 10, 1, (3098), 10.1038/s41467-019-11090-3)
Akentjew, T. L., Terraza, C., Suazo, C., Maksimcuka, J., Wilkens, C. A., Vargas, F., Zavala, G., Ocaña, M., Enrione, J., García-Herrera, C. M., Valenzuela, L. M., Blaker, J. J., Khoury, M. & Acevedo, J. P., 1 Dec 2019, In: Nature Communications. 10, 1, 3508.Research output: Contribution to journal › Comment/debate
Open Access5 Scopus citations -
Cold-adaptation of a methacrylamide gelatin towards the expansion of the biomaterial toolbox for specialized functionalities in tissue engineering
Zaupa, A., Byres, N., Dal Zovo, C., Acevedo, C. A., Angelopoulos, I., Terraza, C., Nestle, N., Abarzúa-Illanes, P. N., Quero, F., Díaz-Calderón, P., Olguín, Y., Akentjew, T. L., Wilkens, C. A., Padilla, C., Zacconi, F. C., Pino-Lagos, K., Blaker, J. J., Khoury, M., Enrione, J. & Acevedo, J. P., Sep 2019, In: Materials Science and Engineering C. 102, p. 373-390 18 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Composition comprising a substantially pure population of multipotent stromal cells encapsulated in platelet-poor plasma.
Brizuela Cordero, D. (Inventor) & Khoury, M. (Inventor), 2019Research output: Patent
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Composition comprising a substantially pure population of multipotent stromal cells encapsulated in platelet-poor plasma (PPP)
Khoury, M. (Inventor), Brizuela, C. (Inventor), Angelopoulos, I. (Inventor) & Brizuela, C. (Inventor), 5 Dec 2019, (Accepted/In press) IPC No. A61K 35/ 51 A I, Patent No. US2019365804, 15 Jan 2018, Priority date 15 Jan 2018, Priority No. WO2018IB50243Research output: Patent
Open Access -
Differentiation of adipose-derived stem cells to functional CD105neg CD73low melanocyte precursors guided by defined culture condition
Zavala, G., Sandoval, C., Meza, D., Contreras, R., Gubelin, W. & Khoury, M., 9 Aug 2019, In: Stem Cell Research and Therapy. 10, 1, 249.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Exosome-like vesicles in Apis mellifera bee pollen, honey and royal jelly contribute to their antibacterial and pro-regenerative activity
Schuh, C. M. A. P., Aguayo, S., Zavala, G. & Khoury, M., 2019, In: Journal of Experimental Biology. 222, 20, jeb.208702.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
Exosomes on the border of species and kingdom intercommunication
Schuh, C. M. A. P., Cuenca, J., Alcayaga-Miranda, F. & Khoury, M., Aug 2019, In: Translational Research. 210, p. 80-98 19 p.Research output: Contribution to journal › Review article › peer-review
38 Scopus citations -
Mesenchymal stem cells improve rheumatoid arthritis progression by controlling memory T cell response
Luque-Campos, N., Contreras-López, R. A., Paredes-Martínez, M. J., Torres, M. J., Bahraoui, S., Wei, M., Espinoza, F., Djouad, F., Elizondo-Vega, R. J. & Luz Crawford, P. A., 2019, In: Frontiers in Immunology. 10, MAR, 798.Research output: Contribution to journal › Review article › peer-review
Open Access93 Scopus citations -
Normality Ranges of Menstrual Fluid Volume during Reproductive Life Using Direct Quantification of Menses with Vaginal Cups
Donoso, M. B., Serra, R., Rice, G. E., Gana, M. T., Rojas, C., Khoury, M., Arraztoa, J. A., Monteiro, L. J., Acuña, S. & Illanes, S. E., 1 Jul 2019, In: Gynecologic and Obstetric Investigation. 84, 4, p. 390-395 6 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations